A network meta‐analysis of different positive airway pressure interventions in obesity hypoventilation syndrome

Abstract

Obesity hypoventilation syndrome (OHS) is defined as obesity, sleep-disordered breathing, and hypercapnic respiratory failure in the absence of another cause of hypoventilation (Iftikhar & Roland, 2018). There is an increasing prevalence of OHS in parallel with the worldwide increase in obesity (Ng et al., 2014) and it is also the most common indication for home non-invasive ventilation (NIV) in many countries (Garner et al., 2013). Because systemic inflammation, endothelial dysfunction, and insulin resistance are more pronounced in people with OHS compared with eucapnic obesity, OHS is associated with several different cardiovascular and metabolic abnormalities, as well as complications such as pulmonary hypertension, cor pulmonale and unstable respiratory failure

Transvenous Phrenic Nerve Stimulation and Positive Airway Pressure devices for Central Sleep Apnea in Patients with Heart Failure with Reduced Ejection Fraction: A Network Meta-analysis

“…This approach has been used in other network meta-analyses. [15,16] Results of network meta-analysis were presented as netgraphs or evidence plots (geometry of evidence), forest plots and network league tables, a square matrix showing all pairwise comparisons in a network meta-analysis. Inconsistency between direct and indirect/network meta-analysis was checked by 'netsplit' tables.…”