A neural circuit arbitrates between perseverance and withdrawal in hungry Drosophila

Sayın, Sercan; Backer, Jean-François De; Wosniack, Marina E.; Lewis, Laurence; Siju, K.P.; Frisch, Lisa M.; Schlegel, Philipp; Edmondson-Stait, Amelia J.; Sharifi, Nadiya; Fisher, Corey B.; Calle-Schuler, Steven A.; Lauritzen, Scott; Bock, Davi D.; Costa, Marta; Jefferis, Gregory S.X.E.; Gjorgjieva, Julijana; Kadow, Ilona C. Grunwald

doi:10.1101/259119

Cited by 10 publications

(3 citation statements)

References 81 publications

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“…Several recent studies agree with such a circuit. For example, activation of octopaminergic VPM4 neurons decreased GCaMP responses in MBON-g1pedc>a/b neurons [49] and activation of PAM-DANs decreased Ca 2+ transients in MBON-g4 in vivo [12]. In addition to MB-b'1, recent data from our group demonstrate neuropeptidergic modulation of other central DANs (PPL1) that project to the vertical MB lobes and also regulate duration of flight bouts [50].…”

Section: Activity In Pam-dans Reduces Gaba Release From Mbons To Suppmentioning

confidence: 76%

Extended Flight Bouts Require Disinhibition from GABAergic Mushroom Body Neurons

et al. 2019

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Section: Activity In Pam-dans Reduces Gaba Release From Mbons To Suppmentioning

confidence: 76%

Extended Flight Bouts Require Disinhibition from GABAergic Mushroom Body Neurons

et al. 2019

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“…Upwind orientation in walking flies appears to depend entirely on mechanical cues while upwind orientation during flight has been shown to be sensitive to visual cues ( Kennedy, 1940 ; Kennedy et al, 1981 ; van Breugel and Dickinson, 2014 ). Searching responses after odor offset have been observed in walking cockroaches ( Willis et al, 2008 ), and have been observed in adult flies following removal from food ( Dethier, 1976 ; Kim and Dickinson, 2017 ) but have until recently not been reported in flies in response to odor ( Sayin et al, 2018 ). The OFF response seems to play a role related to casting in flying insects, allowing the fly to relocate an odor plume once it has been lost, although the response we observed did not have any component of orientation orthogonal to the wind direction, as has been described in flight ( Kennedy and Marsh, 1974 ; van Breugel and Dickinson, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

Álvarez-Salvado

Licata

Connor

et al. 2018

eLife

125

160

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Odor attraction in walking Drosophila melanogaster is commonly used to relate neural function to behavior, but the algorithms underlying attraction are unclear. Here, we develop a high-throughput assay to measure olfactory behavior in response to well-controlled sensory stimuli. We show that odor evokes two behaviors: an upwind run during odor (ON response), and a local search at odor offset (OFF response). Wind orientation requires antennal mechanoreceptors, but search is driven solely by odor. Using dynamic odor stimuli, we measure the dependence of these two behaviors on odor intensity and history. Based on these data, we develop a navigation model that recapitulates the behavior of flies in our apparatus, and generates realistic trajectories when run in a turbulent boundary layer plume. The ability to parse olfactory navigation into quantifiable elementary sensori-motor transformations provides a foundation for dissecting neural circuits that govern olfactory behavior.

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“…Both this diverged preference and high activity of starved flies are known effects described in Drosophila spp. Starved flies move about more actively [87], have higher odour tracking perseverance [88] and a higher response rate when offered a single (food cue) choice [54,58] compared to fed flies. For D. melanogaster and Drosophila simulans , Turelli and Hoffmann (1988) showed in mark–release–recapture experiments that starved flies were less discriminating and prone to be attracted to inferior resources [89].…”

Section: Discussionmentioning

confidence: 99%

Olfactory Preference of Drosophila suzukii Shifts between Fruit and Fermentation Cues over the Season: Effects of Physiological Status

Clymans

Kerckvoorde²,

Bangels³

et al. 2019

Insects

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Worldwide monitoring programs of the invasive fruit pest Drosophila suzukii Matsumura (Diptera: Drosophilidae), using fermentation baits like apple cider vinegar (ACV), revealed a counterintuitive period of low trap catches during summer, followed by an autumn peak. In this study, we demonstrate that ACV baited traps indeed provide a distorted image of the D. suzukii population dynamics as it is possible to capture higher numbers during this “low capture period” with synthetic lures. It was hypothesised that the preference of D. suzukii populations for fermentation cues like ACV is most pronounced during autumn, winter and spring, while the flies prefer fresh fruit cues during summer and that this seasonal preference is related to the changing physiology of the flies over the season. To test this hypothesis, the preference between fermentation cues (ACV) and host fruits (strawberries) and the effect of physiology (sex, seasonal morphology and feeding, mating and reproductive status) was investigated both in olfactometer laboratory experiments and a year-round field preference experiment. In olfactometer experiments we demonstrated that protein deprived females, virgin females with a full complement of unfertilised eggs and males show a strong preference for fermentation cues while fully fed reproductive summer morph females generally prefer fruit cues. These findings indicate that D. suzukii is attracted to fermentation volatiles in search of (protein-rich) food and to fruit volatiles in search of oviposition substrates. Winter morph and starved females displayed indiscriminating olfactory behaviour. In the field preference experiment, the hypothesised seasonal shift between fermentation and fruit cues was confirmed. This shift appeared to be highly temperature-related and was similarly observed for summer and winter morphs.

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A neural circuit arbitrates between perseverance and withdrawal in hungry Drosophila

Cited by 10 publications

References 81 publications

Extended Flight Bouts Require Disinhibition from GABAergic Mushroom Body Neurons

Extended Flight Bouts Require Disinhibition from GABAergic Mushroom Body Neurons

Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

Olfactory Preference of Drosophila suzukii Shifts between Fruit and Fermentation Cues over the Season: Effects of Physiological Status

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