A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

Phillips, Mary L.; Ladouceur, Cecile D.; Drevets, Wayne C.

doi:10.1038/mp.2008.65

Cited by 1,175 publications

(1,238 citation statements)

References 209 publications

(253 reference statements)

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“…These results correspond well with findings from meta analyses investigating structural alterations in BD, repeatedly reporting altered insula and basal ganglia structure in BD compared with HC (Bora et al, 2012). Similarly, functional MRI studies highlighted the role of the insula for reward processing in BD (Phillips et al, 2008a).…”

Section: Reward Processing In Ud and Bdsupporting

confidence: 78%

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Redlich

Dohm

Grotegerd

et al. 2015

Neuropsychopharmacol

143

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Differentiating bipolar disorders (BD) from unipolar depression (UD) remains a major clinical challenge. The identification of neurobiological markers may help to differentiate these disorders, particularly during depressive episodes. This cross-sectional study, including 33 patients with UD, 33 patients with BD, and 34 healthy controls, is one of the first to directly compare UD and BD with respect to reward processing. A card-guessing paradigm was employed and brain activity associated with reward processing was investigated by means of fMRI. A 3 (group) × 2 (condition: reward4control, loss4control) ANOVA was conducted using the nucleus accumbens (NAcc) as ROI. Furthermore, a whole-brain approach was applied. A functional connectivity analysis was performed to characterize diagnosis-related alterations in the functional coupling between the NAcc and other brain areas. The ANOVA revealed higher activity for healthy controls (HCs) than for BD and UD in the NAcc during reward processing. Moreover, UD showed a higher functional connectivity between the NAcc and the VTA than HC. The patients groups could be differentiated in that BD showed a decreased activation, in the reward condition, of the NAcc, caudate nucleus, thalamus, putamen, insula, and prefrontal areas compared with UD. These results may help to refine the understanding of neural correlates of reward processing in both disorders, and to understand the neural underpinnings of anhedonia, a core symptom of depressive episodes.

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Section: Reward Processing In Ud and Bdsupporting

confidence: 78%

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Redlich

Dohm

Grotegerd

et al. 2015

Neuropsychopharmacol

143

View full text Add to dashboard Cite

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“…Depression has been conceptualized as a failure to recruit prefrontal top-down cognitive control to regulate emotion producing subcortical limbic activity (Phillips, Ladouceur, & Drevets, 2008). A meta-analysis of neuroimaging studies revealed evidence for the involvement of two neurocircuits in major depressive disorder.…”

Section: Treatment Mechanisms Of Neurostimulation In Trd a Neurobiolomentioning

confidence: 99%

Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies

Raedt

Vanderhasselt

Baeken

2015

Clinical Psychology Review

105

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Despite the fact that several interventions for major depression have proven efficacy, a substantial number of patients are or become treatment resistant to various forms of pharmacotherapy and psychotherapy. Biological interventions that directly target brain activity such as electroconvulsive therapy are used to treat these patients, but some of these interventions are unlikely to be easily accepted because of their more invasive nature or sideeffects. The efficacy of non-invasive neurostimulation with a favorable side effect profile, such as repetitive Transcranial Magnetic Stimulation, could not be sufficiently demonstrated for treatment resistant depressed patients (TRD). We argue that research on the working mechanisms of these neurostimulation techniques is necessary to develop more efficient treatment protocols. After an overview of current neurostimulation approaches to treatment resistance and the introduction of a neurobiological and a cognitive framework of depression, we provide an integrative review of research on both the neurobiological and cognitive working mechanisms of neurostimulation in TRD, with a specific emphasis on the work of our lab. Thereafter, we describe our own studies and studies from other labs on new neurocognitive interventions. Finally we discuss how all this knowledge can be used to further develop new strategies to deal with treatment resistance, in combining neurostimulation and cognitive interventions.

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“…BD is associated with dysfunction of emotion regulation (Phillips et al, 2008), which involves the initial steps of perception of information eliciting emotional arousal.…”

Section: Introductionmentioning

confidence: 99%

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Najt

Hausmann

2014

Psychiatry Research

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A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

Cited by 1,175 publications

References 209 publications

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

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