A Neurobehavioral Study of Chloralkali Workers after the Cessation of Exposure to Mercury Vapor

Bast‐Pettersen, Rita; Ellingsen, Dag G.; Efskind, Jon; Jordskogen, Rita; Thomassen, Yngvar

doi:10.1016/j.neuro.2005.03.006

Cited by 27 publications

(40 citation statements)

References 22 publications

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“…The study was based on individual matches of pairs of one exposed person with one referent for age (±3 years). Details have been published elsewhere (27).…”

Section: Study Design and Study Populationmentioning

confidence: 99%

“…Total mercury in whole blood (B-Hg) was measured by inductively coupled plasma high-resolution mass spectrometry. The details have been given elsewhere (27).…”

Section: Measurements Of Trace Elementsmentioning

confidence: 99%

“…Serum was prepared for the measurement of selenium (S-Se) using the same procedure as for B-Hg (27) and analyzed for selenium by ETAAS calibrated with serum-matched standard solutions. Reduced palladium was used as a chemical modifier.…”

Section: Measurements Of Trace Elementsmentioning

confidence: 99%

See 2 more Smart Citations

Renal function of chloralkali workers after the cessation of exposure to mercury vapor

Efskind¹,

Ellingsen²,

Hartman³

et al. 2006

Scand J Work Environ Health

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“…The study was based on individual matches of pairs of one exposed person with one referent for age (±3 years). Details have been published elsewhere (27).…”

Section: Study Design and Study Populationmentioning

confidence: 99%

“…Total mercury in whole blood (B-Hg) was measured by inductively coupled plasma high-resolution mass spectrometry. The details have been given elsewhere (27).…”

Section: Measurements Of Trace Elementsmentioning

confidence: 99%

See 1 more Smart Citation

Renal function of chloralkali workers after the cessation of exposure to mercury vapor

Efskind¹,

Ellingsen²,

Hartman³

et al. 2006

Scand J Work Environ Health

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“…Absorbed through the lungs, lipophilic Hg 0 dissolves in blood, easily passes the blood-brain barrier and reacts with organic compounds leading to its accumulation in the brain [1]. Metallic mercury vapor intoxication is accompanied by a wide range of cognitive, personality, sensory and motor disorders [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

HSP70 (HSPA1) polymorphisms for former workers with chronic mercury vapor exposure

Chernyak

Merinova

2017

Int J Occup Med Environ Health

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Objectives: To investigate 4 loci of 3 HSP70 genes in caustic soda production plant former workers, who have been exposed to metallic mercury vapors for a long time, and including numerous cases of chronic mercury intoxication (CMI). Material and Methods: Polymorphisms in HSP70 gene family members (HSP1A1 (+190G/C, rs1043618), HSPA1B (+1267A/G and +2074G/C, rs1061581) and HSP1AL (+2437T/C, rs2227956)) genes were studied among 120 male workers involved in caustic soda production by mercury electrolysis at 2 plants in Eastern Siberia. These subjects had been chronically exposed to metallic mercury vapors for > 5 years and divided into 3 groups based on the occurrence and time of the CMI diagnosis, or absence of this disease. The Group 1 consisted of individuals (N = 46), who had had contact with mercury but were not diagnosed with the CMI. The Group 2 included workers (N = 56), who were diagnosed with the CMI longer than 14 years ago. The Group 3 consisted of the subjects (N = 18), who had been diagnosed with the CMI 3-5 years ago. The logistic regression analysis was used for 3 genetic models with and without adjustment for age and duration of mercury vapor exposure. Results: We found that genotypes СС-HSPA1A (+190G/C) and GG-HSPA1B (+1267A/G) had a high predictive risk of the CMI development (adjusted odds ratio (OR adj ) = 5.58, p = 0.026 and OR adj = 14.7, p = 0.0015, respectively). Twelve individuals with the CMI had a specific combination of СС-HSPA1A (+190G/C) and GG-HSPA1B (+1267A/G) genotypes, which strongly associated with the diagnosis (OR adj = 12.3, p = 0.0285). Moreover, significant association with the CMI was also obtained for the haplotype G-C of 1267A/G and 190G/C polymorphisms (OR = 2.1, p = 0.018). Conclusions: The association of СС-HSPA1A (+190G/C) and GG-HSPA1B (+1267A/G) genotypes and their combination for the CMI individuals suggests the role for HSPA1 genes in mercury-dependent mechanisms of the CMI development and progression. Int J Occup Med Environ Health 2017;30(1):77-85

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“…Only a few have shown results of assessments after the cessation of the chronic exposure to mercury vapor (14,15,(24)(25)(26)(27). Some of these studies did not find significant differences between exposed and controls in any of the cognitive or motor functions assessed (25,27) while others have suggested that neuronal dysfunction is likely to be persistent even years after the end of chronic exposure (5,7,8,14,15,26). The likelihood of reversibility of the neuropsychological deficit is therefore controversial.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological dysfunction related to earlier occupational exposure to mercury vapor

Zachi

Ventura

Faria

et al. 2007

Braz J Med Biol Res

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We assessed the neuropsychological test performances of 26 patients (mean age = 41.5 ± 6.1 years; mean years of education = 9.8 ± 1.8; 20 males) diagnosed with chronic occupational mercurialism who were former workers at a fluorescent lamp factory. They had been exposed to elemental mercury for an average of 10.2 ± 3.8 years and had been away from this work for 6 ± 4.7 years. Mean urinary mercury concentrations 1 year after cessation of work were 1.8 ± 0.9 µg/g creatinine. Twenty control subjects matched for age, gender, and education (18 males) were used for comparison. Neuropsychological assessment included attention, inhibitory control, verbal and visual memory, verbal fluency, manual dexterity, visual-spatial function, executive function, and semantic knowledge tests. The Beck Depression Inventory and the State and Trait Inventory were used to assess depression and anxiety symptoms, respectively. The raw score for the group exposed to mercury indicated slower information processing speed, inferior performance in psychomotor speed, verbal spontaneous recall memory, and manual dexterity of the dominant hand and non-dominant hand (P < 0.05). In addition, the patients showed increased depression and anxiety symptoms (P < 0.001). A statistically significant correlation (Pearson) was demonstrable between mean urinary mercury and anxiety trait (r = 0.75, P = 0.03). The neuropsychological performances of the former workers suggest that occupational exposure to elemental mercury has long-term effects on information processing and psychomotor function, with increased depression and anxiety also possibly reflecting the psychosocial context.

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A Neurobehavioral Study of Chloralkali Workers after the Cessation of Exposure to Mercury Vapor

Cited by 27 publications

References 22 publications

Renal function of chloralkali workers after the cessation of exposure to mercury vapor

Renal function of chloralkali workers after the cessation of exposure to mercury vapor

HSP70 (HSPA1) polymorphisms for former workers with chronic mercury vapor exposure

Neuropsychological dysfunction related to earlier occupational exposure to mercury vapor

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