A neurobehavioral study of current and former welders exposed to manganese

Ellingsen, Dag G.; Константинов, Р В; Bast‐Pettersen, Rita; Merkurjeva, Ludmila; Chashchin, Maxim; Thomassen, Yngvar; Chashchin, Valery

doi:10.1016/j.neuro.2007.08.014

Cited by 117 publications

(91 citation statements)

References 35 publications

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“…Mn intoxication following chronic human exposure in other occupational settings, such as mining, smelting, ferroalloy, and dry battery industries, has been documented to cause a Parkinson's disease-like syndrome called 'manganism' (Roels et al, 1992;Baldwin, 1997, Lucchini et al, 1999). Neurobehavioral changes have been reported in exposed welders (Bowler et al, 2007a, b;Ellingsen et al, 2008), and case reports show Mn accumulates in dopaminergic brain regions of welders exposed to high concentrations of welding fume (Sadek et al, 2003;Josephs et al, 2005). In addition, some studies describe a potential link between welding and Parkinsonism, and suggest the possibility of an early-onset Parkinsonism among welders (Racette et al, 2001(Racette et al, , 2005, whereas other studies do not (Goldman et al, 2005;Stampfer, 2009;Tanner et al, 2009).…”

Section: Welding Exposure and Health Effectsmentioning

confidence: 99%

Immunotoxicology of arc welding fume: Worker and experimental animal studies

Zeidler-Erdely

Erdely

Antonini

2012

Journal of Immunotoxicology

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Section: Welding Exposure and Health Effectsmentioning

confidence: 99%

Immunotoxicology of arc welding fume: Worker and experimental animal studies

Zeidler-Erdely

Erdely

Antonini

2012

Journal of Immunotoxicology

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“…The brain is a critical target organ for Mn deposition as Mn crosses the blood-brain barrier (BBB), and this is the first step in the pathogenesis of the neurotoxicity of Mn. In occupational settings, excessive exposure to Mn via inhalation has been shown to have detrimental effects on the lungs and to accumulate in the brain, causing irreversible brain disease, to some extent similar to Parkinson's disease (PD) [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to manganese in South African coastal communities

Röllin

Kootbodien

Theodorou

et al. 2014

Environ. Sci.: Processes Impacts

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Exposure to environmental sources and altered physiological processes of manganese uptake during pregnancy and its possible effect on prenatal and postnatal development are of concern. This study investigates manganese blood levels at the time of delivery across four cohorts of pregnant women residing in coastal communities of South Africa and examines birth outcomes and environmental factors that could influence manganese levels in the study population. The geometric mean (GM) manganese blood levels (MnB) for all women at delivery was 15.2 µg/L. Collectively, rural women reported higher MnB concentrations (GM, 16.1 µg/L) than urban women (GM, 13.5 µg/L, p<0.001). Of the 302 cord blood samples drawn from the study participants (rural women only), GM MnB levels reported for three rural sites were 25.8 µg/L (Rural 1), 33.4 µg/L (Rural 2) and 43.0 µg/L (Rural 3) and were twice as high as their respective maternal levels. However, no significant correlations were found between maternal and cord MnB levels across the 3 study areas. Factors associated 2 with elevated maternal MnB levels, after adjusting for gestational age were: women living in a rural area (Rural 2) (p = 0.021); women drinking potable water from an outdoor/communal tap sourced from municipality (p = 0.021); drinking water from river/stream (p = 0.036); younger maternal age (p = 0.026); consuming leafy vegetables once a week (p = 0.034); and elevated maternal blood lead concentrations (PbB) (p = 0.002). The results indicate that a MnB concentration in rural women during pregnancy is higher compared to urban women and increases with manganese intake from food and water.

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“…Our results are different from other studies that reported Mn neurotoxicity. For example, welders exposed to Mn have demonstrated decreased motor function (Bowler et al, 2006;Ellingsen et al, 2008), and a previous Mn exposure study in rats also showed altered locomotor activity (Normandi et al, 2004;Tapin et al, 2006;St-Pierre et al, 2001). It is possible that in our study, the exposure duration may not have been long enough to induce structural brain damage and neurobehavioral changes, but sufficient to elicit altered expression of dopamine transporter.…”

Section: Figmentioning

confidence: 66%

Short-term manganese inhalation decreases brain dopamine transporter levels without disrupting motor skills in rats

et al. 2016

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-Manganese (Mn) is used in industrial metal alloys and can be released into the atmosphere during methylcyclopentadienyl manganese tricarbonyl combustion. Increased Mn deposition in the brain after long-term exposure to the metal by inhalation is associated with altered dopamine metabolism and neurobehavioral problems, including impaired motor skills. However, neurotoxic effects of short-term exposure to inhaled Mn are not completely characterized. The purpose of this study is to define the neurobehavioral and neurochemical effects of short-term inhalation exposure to Mn at a high concentration using rats. Male Sprague-Dawley rats were exposed to MnCl 2 aerosol in a nose-only inhalation chamber for 3 weeks (1.2 μm, 39 mg/m 3 ). Motor coordination was tested on the day after the last exposure using a rotarod device at a fixed speed of 10 rpm for 2 min. Also, dopamine transporter and dopamine receptor protein expression levels in the striatum region of the brain were determined by Western blot analysis. At a rotarod speed of 10 rpm, there were no significant differences in the time on the bar before the first fall or the number of falls during the two-minute test observed in the exposed rats, as compared with controls. The Mn-exposed group had significantly higher Mn levels in the lung, blood, olfactory bulb, prefrontal cortex, striatum, and cerebellum compared with the control group. A Mn concentration gradient was observed from the olfactory bulb to the striatum, supporting the idea that Mn is transported via the olfactory pathway. Our results demonstrated that inhalation exposure to 39 mg/m 3 Mn for 3 weeks induced mild lung injury and modulation of dopamine transporter expression in the brain, without altering motor activity.

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A neurobehavioral study of current and former welders exposed to manganese

Cited by 117 publications

References 35 publications

Immunotoxicology of arc welding fume: Worker and experimental animal studies

Immunotoxicology of arc welding fume: Worker and experimental animal studies

Prenatal exposure to manganese in South African coastal communities

Short-term manganese inhalation decreases brain dopamine transporter levels without disrupting motor skills in rats

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