A Neuroendocrinological Study in Female Migraineurs: Prolactin and Thyroid Stimulating Hormone Responses

Awaki, E.; Takeshima, T.; Takahashi, K.

doi:10.1046/j.1468-2982.1989.903187.x

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…The episodic nature of attacks (Alstadhaug et al, 2005(Alstadhaug et al, , 2007, the clinical characteristics of premonitory symptoms (Blau, 1980), the observation that attacks may be triggered by acute changes in sleep pattern (Cortelli & Pierangeli, 2007;Dodick et al, 2003;Kelman & Rains, 2005;Overeem et al, 2002;Rainero et al, 2008) and the finding that serum (Awaki et al, 1989;Elwan et al, 1991;Papakostas et al, 1987;Peres et al, 2001;Sarchielli et al, 2008;van Oosterhout et al, 2018) and cerebrospinal fluid (Elwan et al, 1991;Sarchielli et al, 2008) levels of hypothalamic hormones are abnormal during (Awaki et al, 1989;Elwan et al, 1991;Peres et al, 2001;van Oosterhout et al, 2018) and in-between (Papakostas et al, 1987;Sarchielli et al, 2008;van Oosterhout et al, 2018) migraine attacks all suggest a role for the hypothalamus in the initiation cascade of migraine attacks (Goadsby et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic functional MRI activity in the initiation phase of spontaneous and glyceryl trinitrate‐induced migraine attacks

Oosterhout

Opstal

Schoonman

et al. 2021

Eur J of Neuroscience

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The hypothalamus has been suggested to be important in the initiation cascade of migraine attacks based on clinical and biochemical observations. Previous imaging studies could not disentangle the changes due to the attack and those due to the trigger compound. With a novel approach, we assessed hypothalamic neuronal activity in early premonitory phases of glyceryl‐trinitrate (GTN)‐induced and spontaneous migraine attacks. We measured the hypothalamic blood oxygen level‐dependent (BOLD) response to oral glucose ingestion with 3T‐functional magnetic resonance imaging (MRI) in 27 women, 16 with migraine without aura and 11 controls group matched for age and body mass index (BMI), on 1 day without prior GTN administration and on a second day after GTN administration (to coincide with the premonitory phase of an induced attack). Interestingly, subgroups of patients with and without GTN‐triggered attacks could be compared. Additionally, five migraineurs were investigated in a spontaneous premonitory phase. Linear mixed models were used to study between‐ and within‐group effects. Without prior GTN infusion, the BOLD response to glucose was similar in migraine participants and controls (P = .41). After prior GTN infusion, recovery occurred steeper and faster in migraineurs (versus Day 1; P < .0001) and in those who developed an attack versus those who did not (P < .0001). Prior GTN infusion did not alter the glucose‐induced response in controls (versus baseline; P = .71). Just before spontaneous attacks, the BOLD‐response recovery was also faster (P < .0001). In this study, we found new and direct evidence of altered hypothalamic neuronal function in the immediate preclinical phase of both GTN‐provoked and spontaneous migraine attacks.

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Section: Introductionmentioning

confidence: 99%

Hypothalamic functional MRI activity in the initiation phase of spontaneous and glyceryl trinitrate‐induced migraine attacks

Oosterhout

Opstal

Schoonman

et al. 2021

Eur J of Neuroscience

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Evidence for hyperprolactinemia in migraineurs: a systematic review and meta-analysis

et al. 2019

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Background One of the hypothalamus-pituitary axis hormones which may play a crucial role in pathophysiology of migraine is prolactin which is secreted from anterior pituitary gland and synthesized by various immune system cells as well. Whether prolactin blood levels can affect the migraine pathogenesis is an open question. Therefore, investigating prolactin circulatory levels in migraineurs may pave the way to underpin the mechanisms of migraine pathophysiology at biochemical levels. In the current investigation, the prolactin blood levels in the migraine subjects were investigated using systematic review and metaanalysis. Methods Using online and specialized biomedical databases including Google Scholar, Medline, Pubmed, Pubmed Central, Embase, and Scopus, without the beginning date restriction until Feb 2019, the systematic review retrieved 11 publications in this systematic review after fulfilling for the inclusion and exclusion criteria. For heterogeneity, extent calculation statistical testing was applied. In the present study, the levels of circulatory prolactin in migraineurs assessed using standardized mean difference (SMD) as the effect size. Results Q quantity and I 2 % statistic index showed a high heterogeneity in the 13 selected publications (188.370 and 92.568, respectively) and random-effects model was chosen for further analyses. The meta-analysis on a total number of 460 migraineurs and 429 healthy controls found that the weighted pooled SMD for the effects of prolactin blood concentrations on migraine pathogenesis was as follows: SMD = 1.435 (95% confidence interval, 0.854-2.015). Conclusion The current investigation presents evidence that prolactin blood levels are higher in migraineurs than healthy subjects.

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Relationship between high prolactine levels and migraine attacks in patients with microprolactinoma

et al. 2008

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The pathophysiology of pituitary-associated headache is unknown, although structural and functional features of the tumour are proposed mechanisms. The objective of this study was to evaluate whether headache in a population with pituitary micro-adenomas was related to hyperprolactinemia. We recruited 29 patients with microprolactinoma and headache: 16 with migraine (group A) and 13 with tension-type-headache (group B). The prolactin (PRL) levels measured during attacks of headache were significantly higher in nine patients (56%) of group A and in one patient (8%) of group B. In four of the nine patients of group A, PRL increased after thyrotropin-releasing-hormone (TRH) test and induced severe attacks. After dopamine-agonist (DA) treatment, the headache improved in seven (44%) patients of the group A and in two (15%) patients of the group B. Three of the four patients in whom the TRH-test induced headache attacks, improved after DA treatment. We suggest that hyperprolactinemia may contribute to development of pain in migraine subgroups and further TRH-test could be used to predict which patients could benefit by DA therapy.

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A Neuroendocrinological Study in Female Migraineurs: Prolactin and Thyroid Stimulating Hormone Responses

Cited by 6 publications

References 17 publications

Hypothalamic functional MRI activity in the initiation phase of spontaneous and glyceryl trinitrate‐induced migraine attacks

Hypothalamic functional MRI activity in the initiation phase of spontaneous and glyceryl trinitrate‐induced migraine attacks

Evidence for hyperprolactinemia in migraineurs: a systematic review and meta-analysis

Relationship between high prolactine levels and migraine attacks in patients with microprolactinoma

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