A Neuroethics Backbone for the Evolving Canadian Brain Research Strategy

Illes, Judy; Weiss, Samuel; Bains, Jaideep S.; Chandler, Jennifer A.; Conrod, Patricia J.; Fellows, Lesley K.; Groetzinger, Deanna; Racine, Éric; Robillard, Julie M.; Sokolowski, Marla B.

doi:10.1016/j.neuron.2018.12.021

Cited by 16 publications

(11 citation statements)

References 10 publications

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“…For example, in the Zhangjiang International Brain BioBank (Shanghai) alone, neuroimaging/neurocognitive/environmental/gut microbiota data and corresponding blood samples have been collected from 7500 healthy subjects and 4400 patients with various mental disorders. 35 Lastly, it should be noted that some other countries and organisations have also launched brain projects after 2010 (table 2), such as Korea (2016), 36 the UK (2010), 37 Canada (2017), 38 Israel (2011), 39 Australia (2016) 40 and the International Brain Laboratory (2016, inte rnat iona lbra inlab. com), constituting a worldwide array of brain science.…”

Section: The Array Of National Brain Projectsmentioning

confidence: 99%

“…Lastly, it should be noted that some other countries and organisations have also launched brain projects after 2010 (table 2), such as Korea (2016),36 the UK (2010),37 Canada (2017),38 Israel (2011),39 Australia (2016)40 and the International Brain Laboratory (2016, internationalbrainlab.com), constituting a worldwide array of brain science 18. Moreover, many non-governmental bodies and private institutions are active in brain-related research as well, such as the famous Allen Institute for Brain Science (www.alleninstitute.org), Tianqiao and Chrissy Chen Institute (www.cheninstitute.org), and the Simons Collaboration on the Global Brain (simonsfoundation.org).…”

Section: The Array Of National Brain Projectsmentioning

confidence: 99%

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Decoding psychosis: from national genome project to national brain project

Sun

Shi

et al. 2022

Gen Psych

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The mind has puzzled humans for centuries, and its disorders, such as psychoses, have caused tremendous difficulties. However, relatively recent biotechnological breakthroughs, such as DNA technology and neuroimaging, have empowered scientists to explore the more fundamental aspects of psychosis. From searching for psychosis-causing genes to imaging the depths of the brain, scientists worldwide seek novel methods to understand the mind and the causes of its disorders. This article will briefly review the history of understanding and managing psychosis and the main findings of modern genetic research and then attempt to stimulate thought for decoding the biological mechanisms of psychosis in the present era of brain science.

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Section: The Array Of National Brain Projectsmentioning

confidence: 99%

Section: The Array Of National Brain Projectsmentioning

confidence: 99%

Decoding psychosis: from national genome project to national brain project

Sun

Shi

et al. 2022

Gen Psych

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“…Transcriptome-wide approaches, including microarray, bulk RNA sequencing, and single-cell RNA sequencing, can all be used to perform a highdimensional, unbiased validation of iPSC-derived cellular models. For example, single-cell RNA sequencing can be used to validate neurons that give rise to heterogeneous, but regionspecific cell types, such as hippocampal neurons (Illes et al 2019).…”

Section: Validity Of the Ipsc Model Systemmentioning

confidence: 99%

Modeling Brain Disorders Using Induced Pluripotent Stem Cells

Vadodaria

Jones

Linker

et al. 2019

Cold Spring Harb Perspect Biol

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Brain disorders, from neurodegenerative to psychiatric disorders, are among the most challenging conditions to study because of the intricate nature of the human brain and the limitations of existing model systems in recapitulating all these intricacies. However, innovations in stem cell technologies now allow us to reprogram patient somatic cells to induced pluripotent stem cells (iPSCs), which can then be differentiated to disease-relevant neural and glial cells. iPSCs are a valuable tool to model brain disorders, as they can be derived from patients with known symptom histories, genetics, and drug-response profiles. Here, we discuss the premise and validity of the iPSC-based in vitro model system and highlight key findings from the most commonly studied neurodegenerative and psychiatric disorders.N europsychiatric and neurodegenerative disorders constitute a bulk of brain disorders, contributing significantly to the global burden of disease. The uniquely human abilities of higherorder thought, symbolic abstract thought, and the ability to generate and share complex ideas emerged along with a large brain. Disorders of the brain are therefore challenging to study as no single model system fully encapsulates the complexity of the human brain, one of the least accessible organs within the body. While postmortem data can provide information regarding the end-stage pathology of a disease, its causes and consequences remain difficult to parse. While animal models provide a complex and live system that enables us to study specific endophenotypes of disorders, they do not fully recapitulate the complex human-specific pathology. Therefore, more model systems are required.

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“…Large, global, coordinated initiatives reflect the scale, size, and cost of the technology and the disciplinary complexity necessary to tackle these great challenges. In the past few years, seven national or regional brain research initiatives in the United States, the European Union, China, Australia, Japan, Korea, and Canada have joined together under the umbrella of the International Brain Research Initiative (http://www.internationalbraininitiative.org) (Illes et al 2019;Grillner et al 2016). Collectively, these initiatives represent a potential investment of more than US$7 billion in neuroscience research (Global Neuroethics Summit Delegates 2018).…”

Section: Toward a Global Neuroethicsmentioning

confidence: 99%

Neuroethics at 15: The Current and Future Environment for Neuroethics

Force¹

2019

AJOB Neuroscience

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Neuroethics research and scholarship intersect with dynamic academic disciplines in science, engineering, and the humanities. On the occasion of the 15th anniversary of the formation of the International Neuroethics Society, we identify current and future topics for neuroethics and discuss the many social and political challenges that emerge from the converging dynamics of neurotechnologies and artificial intelligence. We also highlight the need for a global, transdisciplinary, and integrated community of researchers to address the challenges that are precipitated by this rapid sociotechnological transformation.

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A Neuroethics Backbone for the Evolving Canadian Brain Research Strategy

Cited by 16 publications

References 10 publications

Decoding psychosis: from national genome project to national brain project

Decoding psychosis: from national genome project to national brain project

Modeling Brain Disorders Using Induced Pluripotent Stem Cells

Neuroethics at 15: The Current and Future Environment for Neuroethics

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