A neurophysiological investigation of anticipation to pain in Parkinson's disease

Martin, Sarah; Jones, Anthony; Brown, Christopher; Kobylecki, Christopher; Silverdale, Monty

doi:10.1111/ejn.14559

Cited by 10 publications

(5 citation statements)

References 61 publications

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“…in fibromyalgia), or other neurological diseases (e.g. Parkinson disease [ 87 ]). Our findings highlight that investigating anticipation processes, and hence expectations, can be fruitful in migraine as well.…”

Section: Discussionmentioning

confidence: 99%

Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio

et al. 2021

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Previous studies targeting inter-individual differences in pain processing in migraine mainly focused on the perception of pain. Our main aim was to disentangle pain anticipation and perception using a classical fear conditioning task, and investigate how migraine frequency and pre-scan cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio as an index of neurobiological stress response would relate to neural activation in these two phases. Functional Magnetic Resonance Imaging (fMRI) data of 23 participants (18 females; mean age: 27.61± 5.36) with episodic migraine without aura were analysed. We found that migraine frequency was significantly associated with pain anticipation in brain regions comprising the midcingulate and caudate, whereas pre-scan cortisol-to DHEA-S ratio was related to pain perception in the pre-supplementary motor area (pre-SMA). Both results suggest exaggerated preparatory responses to pain or more general to stressors, which may contribute to the allostatic load caused by stressors and migraine attacks on the brain.

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Section: Discussionmentioning

confidence: 99%

Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio

et al. 2021

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“…All pains are more prevalent in the advanced stages of the disease. The brain damage modifies the top-down processing of pain, making patients with Parkinson's disease more sensitive to peripheral pain stimulation [16]. Most of the pain symptoms are related to the motor symptoms of the disease but show different responses to dopaminergic replacement [17].…”

Section: Pain In Parkinson's Diseasementioning

confidence: 99%

Pharmacological treatment of palliative care patients with Parkinson’s disease

Żylicz

2022

Palliat Med Pract

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Parkinson's disease is the commonest neurodegenerative condition, which can be eased for a long while, however, it inevitably leads to patients' death. Dying with Parkinson's disease can be problematic as the clinical situation may change dynamically and necessitate frequent drug dose changes and the introduction of new, preferably injectable, drugs may be necessary. Current treatment of Parkinson's disease aims to increase the brain's dopamine focusing mainly on the motor symptoms. The patients suffer frequently from sudden "on" and "off" fluctuations of muscle rigidity accompanied by extreme pain. Classic dopaminergic treatments wear off and become ineffective. The new drug safinamide has been introduced recently with a promising effect on motor and non-motor symptoms including pain. If unavailable, opioids or cannabinoids to relax muscles are the second-best choice. Also, non-motor symptoms like depression, delirium and psychosis may dominate in dying which necessitates antipsychotic treatment with clozapine or quetiapine even if these drugs may hasten deterioration and result in death.

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“…The acute and fast activation of the A-delta fibres allowed for a precise anticipation period. In addition, the CO 2 laser has been used to investigate the anticipatory response in previous studies [51,[90][91][92]. The CO extsubscript2 laser delivered a beam with a diameter of 15 mm and 150 ms duration.…”

Section: Pain Stimulimentioning

confidence: 99%

“…in previous studies [51,[90][91][92]. The CO₂ laser delivered a beam with a diameter of 15 mm and 150 ms duration.…”

Section: Main Experimentsmentioning

confidence: 99%

Altered Pain Processing Associated with Administration of Dopamine Agonist and Antagonist in Healthy Volunteers

et al. 2022

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Striatal dopamine dysfunction is associated with the altered top-down modulation of pain processing. The dopamine D2-like receptor family is a potential substrate for such effects due to its primary expression in the striatum, but evidence for this is currently lacking. Here, we investigated the effect of pharmacologically manipulating striatal dopamine D2 receptor activity on the anticipation and perception of acute pain stimuli in humans. Participants received visual cues that induced either certain or uncertain anticipation of two pain intensity levels delivered via a CO2 laser. Rating of the pain intensity and unpleasantness was recorded. Brain activity was recorded with EEG and analysed via source localisation to investigate neural activity during the anticipation and receipt of pain. Participants completed the experiment under three conditions, control (Sodium Chloride), D2 receptor agonist (Cabergoline), and D2 receptor antagonist (Amisulpride), in a repeated-measures, triple-crossover, double-blind study. The antagonist reduced an individuals’ ability to distinguish between low and high pain following uncertain anticipation. The EEG source localisation showed that the agonist and antagonist reduced neural activations in specific brain regions associated with the sensory integration of salient stimuli during the anticipation and receipt of pain. During anticipation, the agonist reduced activity in the right mid-temporal region and the right angular gyrus, whilst the antagonist reduced activity within the right postcentral, right mid-temporal, and right inferior parietal regions. In comparison to control, the antagonist reduced activity within the insula during the receipt of pain, a key structure involved in the integration of the sensory and affective aspects of pain. Pain sensitivity and unpleasantness were not changed by D2R modulation. Our results support the notion that D2 receptor neurotransmission has a role in the top-down modulation of pain.

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A neurophysiological investigation of anticipation to pain in Parkinson's disease

Cited by 10 publications

References 61 publications

Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio

Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio

Pharmacological treatment of palliative care patients with Parkinson’s disease

Altered Pain Processing Associated with Administration of Dopamine Agonist and Antagonist in Healthy Volunteers

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