A neuropsychological assessment of frontal cognitive functions in Prader–Willi syndrome

Jauregi, J.; Arias, Carlos F.; Vegas, Oscar; Alén, Francisco; González-Martínez, Silvia; Copet, P.; Thuilleaux, Denise

doi:10.1111/j.1365-2788.2006.00883.x

Cited by 85 publications

(65 citation statements)

References 58 publications

(66 reference statements)

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“…Theory of mind is a concept describing the cognitive attribute that allows us to understand the thinking of others and to take into account their views (Baron-Cohen et al, 2000), whereas empathy is part of the interpersonal processes that are crucial for healthy social and moral development (Eisenberg and Fabes, 2006). Besides social disturbances, individuals with PWS had more behavioral and psychiatric problems than did age-matched mentally retarded patients but comparable scores with patients with psychiatric disorders (Jauregi et al, 2007).…”

Section: Psychiatric Disorders and Social Disturbances In Patients Wimentioning

confidence: 86%

PET Scan Perfusion Imaging in the Prader–Willi Syndrome: New Insights into the Psychiatric and Social Disturbances

Mantoulan

Payoux

Diene

et al. 2010

J Cereb Blood Flow Metab

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The Prader-Willi syndrome (PWS), a rare multisystem genetic disease, leads to severe disabilities, such as morbid obesity, endocrine dysfunctions, psychiatric disorders, and social disturbances. We explored the whole brain of patients with PWS to detect abnormalities that might explain the behavioral and social disturbances, as well as the psychiatric disorders of these patients. Nine patients with PWS (six males, three females; mean age 16.4 years) underwent a positron emission tomography (PET) scan with H 2 15 O as a tracer to measure regional cerebral blood flow (rCBF). The images were compared with those acquired from nine controls (six males, three females; mean age 21.2 years). A morphologic magnetic resonance imaging (MRI) was also performed in PWS patients, and their cognitive and behavioral skills were assessed with Wechsler Intelligence Scale for Children III and the Child Behavior Check List (CBCL). The MRI images showed no evident anatomic abnormalities, whereas PET scans revealed hypoperfused brain regions in PWS patients compared with controls, particularly in the anterior cingulum and superior temporal regions. We observed a significant relationship (P < 0.05) between rCBF in the hypoperfused regions and CBCL scores. The functional consequences of these perfusion abnormalities in specific brain regions might explain the behavioral and social problems observed in these individuals.

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Section: Psychiatric Disorders and Social Disturbances In Patients Wimentioning

confidence: 86%

PET Scan Perfusion Imaging in the Prader–Willi Syndrome: New Insights into the Psychiatric and Social Disturbances

Mantoulan

Payoux

Diene

et al. 2010

J Cereb Blood Flow Metab

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“…The most frequent psychological complaints are of the emotional-affective type, psychotic disorders spectrum complaints, withdrawal, mood changes and depression (Benarroch et al, 2007;Dykens & Roof, 2008;Goldstone et al, 2004;Goos & Ragsdale, 2008;Gunay-Aygun et al , 2001;Hinton et al, 2006;Jauregi et al, 2007;Koenig et al, 2004;Semenza et al, 2008. ) Altough the interest for the sudy of mood disorders in people with PWS dates back to the 1990's (Dykens & Cassidy, 1995), recent research have been trying to assess the association between certain types of mood disorders and two of the main genetic subtypes of the disease: deletion and maternal uniparental disomy (Hartley et al, 2005).…”

Section: Prader Willi Syndromementioning

confidence: 99%

Mood Disorders in Individuals with Genetic Syndromes and Intellectual Disability

Teixeira¹,

Mesquita²,

Araújo³

et al. 2012

Clinical, Research and Treatment Approaches to Affective Disorders

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“…Alterações nas funções executivas foram também descritas na Síndrome de Prader-Willi (Jauregi et al, 2007) e na Síndrome de Down (Lanfranchi et al, 2010;Rowe et al, 2006). Na primeira, os autores tinham como objetivo identificar os processos prejudicados, o que poderia auxiliar na compreensão dos mecanismos subjacentes ao déficit de cognição social e desordem de comportamento social frequentemente associados à síndrome.…”

Section: Algumas Evidências De Alterações Executivas Em Crianças Com unclassified

Alterações das funções executivas em crianças e adolescentes

Dias

Menezes

Seabra

2010

Estud. Interdiscip. Psicol.

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ResumoFunções executivas constituem um conjunto de processos cognitivos que permitem a regulação da cognição e do comportamento, possibilitando o engajamento do indivíduo em ações complexas. Essas habilidades estão comprometidas em uma diversidade de condições clínicas e este artigo teórico teve como objetivo oferecer uma revisão não-sistemática de alguns quadros nos quais estas habilidades apresentam-se prejudicadas, sobretudo em crianças e adolescentes. Verificou-se que condições como transtorno do déficit de atenção e hiperatividade, transtorno obsessivo-compulsivo, síndrome de Tourette, transtornos globais do desenvolvimento, transtornos de aprendizagem como a dislexia e a discalculia, além de alterações cromossômicas, como a síndrome de Down e de Prader-Willi, cursam com algum grau de comprometimento do funcionamento executivo. Este conhecimento tem implicações à prática e à pesquisa psicológica e pode ser útil a profissionais que atuam com crianças e adolescentes com alguma destas condições, contribuindo a um maior conhecimento acerca das funções executivas e suas alterações. Palavras-chave: funcionamento executivo, neuropsicologia, desenvolvimento. EXECUTIVE FUNCTIONS DAMAGE IN CHILDREN AND ADOLESCENTS AbstractExecutive functions are a set of cognitive skills that allows the cognition and the behavior regulation, enabling an individual to take part in complex actions. Those abilities are committed in a diversity of clinical conditions and this theoretical article aimed offer an unsystematic revision of some conditions in which these abilities are injured, especially in children and adolescents. It was verified that conditions as Attention Deficit Hyperactivity Disorder, ObsessiveCompulsive Disorder, Tourette Syndrome, Pervasive Developmental Disorders, Learning Disabilities, like as Dyslexia and Dyscalulia, beyond cromossomic alterations, as Down's and Prader-Willi Syndromes, follow with some degree of executive functioning compromise. This knowledge has implications to the psychological practice and research, and can be useful to professionals who act with children and adolescents with some of these conditions, contributing to a greater knowledge about executive functions and its damages.

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A neuropsychological assessment of frontal cognitive functions in Prader–Willi syndrome

Cited by 85 publications

References 58 publications

PET Scan Perfusion Imaging in the Prader–Willi Syndrome: New Insights into the Psychiatric and Social Disturbances

PET Scan Perfusion Imaging in the Prader–Willi Syndrome: New Insights into the Psychiatric and Social Disturbances

Mood Disorders in Individuals with Genetic Syndromes and Intellectual Disability

Alterações das funções executivas em crianças e adolescentes

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