CO 2 capture and sequestration is inevitable. The concentration of the CO 2 in the atmosphere is increasing continuously which will cause global warming among other consequences. Among storage options, the underground storage in depleted oil and gas reservoirs and unminable coals are considered the most economical storage options. On the other hand, natural gas consumption, which is considered to be a clean fuel, has increased significantly during the past years. Therefore seeking for new unconventional energy resources, especially gas seems to be inevitable. This goal is followed not only because of economical benefits but also because of environmental issues we are encountering these days. The purpose of this study is to develop an Artificial Neural network (ANN) tool to predict the important performance indicators such as methane recovered and CO 2 injected, which are critical in CO2 storage projects in coal seams. We have combined the simulation method with artificial intelligence tools to predict the complex behavior of coal bed methane (CBM) reservoirs.In the first step a simulation is done using CMG software. A dual porosity model, which accounts for the optimum conditions during CO 2 sequestration and consequently the optimum methane recovery from coal bed reservoirs was developed. Then the data extracted from the simulated CBM reservoir was employed to train the ANN model. Different parameters related to the coal seam such as porosity, permeability, initial pressure, thickness, temperature and initial water saturation are considered as the input for the network. The outputs are the CO 2 injected and the recovered methane, which show the performance of the CO 2 injection project. The Back-Propagation learning algorithm was used and different transfer functions and numbers of hidden layers were tried to find the best model with the least error. The tested neural network predictions were plotted versus the real data available and also different error analyses were carried out to prove the accuracy of the model. The R-Squared for the predicted values for the CO 2 injected and the recovered methane were 0.92 and 0.94; the average percent arithmetic deviations were 4.8% and 4.5% respectively.