A New 2,3-Dioxygenated Flavanone and Other Constituents from Dysosma difformis

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

“…The mechanism of a non-competitive manner was also reported in his study. Additionally, dysosmaflavanone ( 26 ), a deoxygenated flavanonol from Dysosma difformis, is also included in this review and has been recorded to exhibit weak inhibition against both enzymes in one study [ 81 ].…”

“…As a 2’-prenyl derivative of compound 76, podoverine A (77) could inhibit both enzymes of interest, yet two times weaker than acarbose, reported in one study by Van Thanh et al (2022) [ 81 ]. This study also extracted and evaluated the digestive enzyme inhibitory effects of 8,2’-diprenylquercetin 3-methyl ether (78) , and it was found to be relatively good as acarbose [ 81 ]. Solophenol D (79) is a 2’-geranyl derivative of quercetin.…”

“…On the other hand, some studies have argued that this phenomenon depended on the position of the substitutions [ 62 , 93 , 192 ]. While the impact of the methoxylation remains disputable, the prenylation of the flavonols appeared to increase the inhibitory potential against α-glucosidase [ 81 , 193 ].…”