Fatigue damage, time-dependent creep damage and their interaction are considered as the main failure mechanisms for many high temperature structural components. A generalized methodology for predicting both the high temperature low cycle fatigue (HTLCF) and creep-fatigue lives by using the hysteresis energy density rate (HEDR) and fatigue damage stress concepts was proposed.Experimental data for HTLCF and creep-fatigue in Alloy 617, Haynes 230 and