A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on <i>in vivo</i> analysis of optical properties by high‐definition optical coherence tomography

Boone, Marc; Suppa, Mariano; Marneffe, A.; Miyamoto, Makiko; Jemec, Gregor B. E.; Marmol, Véronique Del

doi:10.1111/jdv.13720

Cited by 35 publications

(27 citation statements)

References 39 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Its incidence has tripled during the past decades despite continued efforts to implement primary prevention strategies. 2 Exposure to ultraviolet (UV) light has been identified as major contributor for the development of NMSC and particularly for keratinocyte skin cancers. 3 Epidemiologic data suggest an increased risk of NMSC in persons with a prolonged or intense occupational or recreational sun-exposure, 1,3 such as postal and construction workers, 4 mountain guides, 5 military personal 6 but also athletes such as marathon runners.…”

Section: Introductionmentioning

confidence: 99%

Sun‐protection and sun‐exposure habits among sailors: results of the 2018 world's largest sailing race Barcolana’ skin cancer prevention campaign

Zalaudek

Conforti

Corneli

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Epidemiologic data suggest an increased risk of melanoma (MM) and non‐melanoma skin cancer (NMSC) in persons with intense recreational sun‐exposure such as marathon runners or surfers. Up to data little is known about the sun‐exposure habits, sun‐protection behaviours and risk factors for MM and NMSC among sailors. Objective The objective of this prospective, cross‐sectional study was to investigate the sun‐exposure and sun‐protective habits and risk factors for skin cancer among sailors attending the 50° edition of Barcolana, the largest sailing race in of the world, which took place in October 2018 in Trieste, Italy as an integrative component of a public sun‐prevention campaign. Methods The study consisted of 2 parts: (i) a self‐administered questionnaire focusing on sun‐exposure and protective habits and (ii) a free skin examination carried out by volunteer dermatologists. Participation was optional and anonymous, and open to visitors and sailors attending the event. Results Overall, 431 (52.4%) sailors and 391 (47.6%) visitors responded to the questionnaire, while a total of 437 individuals including 189 (43.3%) sailors and 248 (56.6%) visitors participated in the skin examination group. The majority of sailors reported a past history of severe sunburns (20.2%), applied sunscreen never (14.4%) to sometimes (45.7%) or only once daily (59%) on the face (55%) and shoulders (26%). Moreover, 14% of sailors had a personal history of non‐melanoma skin cancer (NMSC). During the dermatological examination, suspicious lesions for skin cancer (including MM and NMSC) were identified in 37% of the sailors. Conclusion Our findings support the need to develop and promote primary and secondary prevention strategies to improve the sun‐exposure and sun‐protective habits among sailors.

show abstract

Section: Introductionmentioning

confidence: 99%

Sun‐protection and sun‐exposure habits among sailors: results of the 2018 world's largest sailing race Barcolana’ skin cancer prevention campaign

Zalaudek

Conforti

Corneli

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…The main histological features of AKs can be identified by OCT, that is, hyperkeratosis, thickening and disruption of the epidermal layer, architectural disarray with varying degrees of loss of the dermoepidermal junction (DEJ).Additional features are the presence of a dark band strongly delimitating the epidermis, hyperreflective streaks and dots corresponding to dense hyperkeratotic areas as well as a mesh vascular pattern in the depth when using dynamic OCT . The imaging of AKs and of SCC can be disturbed by hyperkeratosis, which may negatively influence the analysis of underlying structures . A sensitivity of 94% to 100% and a specificity of 28% to 76% in diagnosing AKs by means of OCT have been reported .…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive monitoring of subclinical and clinical actinic keratosis of face and scalp under topical treatment with ingenol mebutate gel 150 mcg/g by means of reflectance confocal microscopy and optical coherence tomography: New perspectives and comparison of diagnostic techniques

Ruini

Hartmann

Bastian

et al. 2019

Journal of Biophotonics

View full text Add to dashboard Cite

Actinic keratosis (AK) corresponds to the earliest stage of in situ squamous cell carcinoma and arises on chronically sun‐exposed skin. Around the clinically evident AKs, the apparently healthy epidermis may contain different grades of atypia that can be detected by noninvasive imaging techniques such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Subclinical actinic keratosis (sAK) has captured increasing interest as a potential target of field therapies. The aim of this study was to evaluate in vivo the changes in the field cancerization undergoing treatment with topical ingenol mebutate by combining RCM and OCT. Twenty patients with field cancerization of the face and scalp were treated with ingenol mebutate gel (150 mcg/g) for three consecutive days on an area of 25 cm2 containing at least two AKs, two sAKs and two apparently healthy sites. About 120 lesions were evaluated through clinical investigation and clinical, dermoscopical, RCM and OCT images at day 0, 4, 14 and 56 based on the diagnostic criteria for AKs. Main pathological features improved in both AKs and sAKs, in particular the epidermal thickness measured by OCT and the epidermal atypia graded by RCM. Local skin reactions (LSR) arose predominantly in the lesional area compared with healthy skin. A complete clearance was detected in 58% for AKs, and in 55% and 72% for sAKs measured by RCM and OCT, respectively. Both OCT and RCM allow the morphological representation of field cancerization including subclinical lesions and provide complementary information. Ingenol mebutate is effective not only in clinically evident but also in sAKs. The differences in LSR highlight the potential selectivity of the treatment.

show abstract

“…Image processing techniques can be applied with the goal of performing automatic interpretation of the images for delimitation or classification tasks, and hence facilitate the acceptance of the technology. However, due to the mentioned challenges, there have been just few attempts of applying these kinds of methods to OCT images of the skin [13][14] [15] on tasks that aim automatic classification. The results obtained so far do not have enough sensibility and specificity, and thus cannot be adopted in the clinical routine.…”

Section: Introductionmentioning

confidence: 99%

Automatic pigmented lesion segmentation through a dermoscopy-guided OCT approach for early diagnosis

Sarachaga

Lage

Morales

et al. 2019

Photonics in Dermatology and Plastic Surgery 2019

View full text Add to dashboard Cite

show abstract

A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high‐definition optical coherence tomography

Cited by 35 publications

References 39 publications

Sun‐protection and sun‐exposure habits among sailors: results of the 2018 world's largest sailing race Barcolana’ skin cancer prevention campaign

Sun‐protection and sun‐exposure habits among sailors: results of the 2018 world's largest sailing race Barcolana’ skin cancer prevention campaign

Non‐invasive monitoring of subclinical and clinical actinic keratosis of face and scalp under topical treatment with ingenol mebutate gel 150 mcg/g by means of reflectance confocal microscopy and optical coherence tomography: New perspectives and comparison of diagnostic techniques

Automatic pigmented lesion segmentation through a dermoscopy-guided OCT approach for early diagnosis

Contact Info

Product

Resources

About