A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata

Huang, Sheng‐Dian; Zhang, Yu; He, Hongping; Li, Shi-Fei; Tang, Gui‐Hua; Chen, Duo-Zhi; Cao, Mingming; Di, Ying‐Tong; Hao, Xiao‐Jiang

doi:10.3724/sp.j.1009.2013.00406

Cited by 22 publications

(11 citation statements)

References 14 publications

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“…Pi et al, [60] reported that some alkaloids isolated from bulb of L. aurea showed significant cytotoxicity against all tumor cell line (seven) tested. The alkaloids 3-0-ethyltazettinol 2α-methoxy-6-O-ethyloduline have also been isolated from the bulb of L. aurea [61], [62].…”

Section: Discussionmentioning

confidence: 99%

Determination of allelopathic potentials in plant species in Sino-Japanese floristic region by sandwich method and dish pack method

Appiah

Zeng

et al. 2015

IJBAS

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The Sino-Japanese Floristic Region appears as one of the major centers of development of higher plants. This region have been relevant for the study of evolution and systematics of many flowering plants. The taxonomic richness of endemic plant species in this region have survived several years of extreme climate conditions. Endemic mountainous plant species that have survived extreme climate conditions are of allelopathic and medicinal interest. For this reason, 251 plant species collected from the Sino-Japanese Floristic Region were screened for allelopathic plant species. Sandwich method and dish pack method were respectively used to screen plant leaf leachates and volatile materials with lettuce (Lactuca sativa CV. Great Lakes 366) as receptor plant. Among the 84 species that showed inhibitory effect on lettuce radicle elongation in our sandwich bioassay, Photinia glabra showed complete inhibition of lettuce radicle elongation (0% radicle elongation). In the dish pack bioassay, Photinia glabra, Liquidambar styraciflua, and Cinnamomum camphora (90.6%, 61.4%, and 50.2% respectively) were among the nine species that were observed with strong inhibitory effect on lettuce radicle growth. On the other hand, nine other species promoted lettuce radicle growth when compared to the control. Aesculus turbinata and Quercus gilva were the species with the highest growth stimulatory effect (33.0% and 16.1% respectively). We hereby present Photinia glabra as an allelopathic candidate species for both leachate and volatile compounds.

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Section: Discussionmentioning

confidence: 99%

Determination of allelopathic potentials in plant species in Sino-Japanese floristic region by sandwich method and dish pack method

Appiah

Zeng

et al. 2015

IJBAS

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“…Professor Einstein resulted in the isolation of 23 known AA , and a new alkaloid (24). The compounds were analyzed by various spectroscopic methods (GC-MS, LC-MS, and 1D and 2D NMR spectroscopy) and identified by comparison with literature data as masonine (1) [22], homolycorine (2) [23], ismine (3) [24], caranine (4) [25], galanthamine (5) [26], narwedine (6) [27], lycoraminone (7) [28], pluviine (8) [25], incartine (9) [29], galanthine (10) [30], lycoramine (11) [26], epinorgalanthamine (12) [31], norlycoramine (13) [32], haemanthamine (14) [32], hippeastrine (15) [33], epimaritidine (16) [34], lycorine (17) [35], tazettine (18) [36], eugenine (19) [37], norpluviine (20) [38], 9-O-demethylmaritidine (21) [39], pancracine (22) [40], and 9-O-demethylhomolycorine (23) [23] (Figure 1). The alkaloids that were isolated were representatives of the homolycorine (1,2,15,19,23), galanthamine (5,6,…”

Section: Isolation and Identification Of Amaryllidaceae Alkaloids Fromentioning

confidence: 99%

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity

Breiterová

Koutová

Maříková

et al. 2020

Plants

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In this detailed phytochemical study of Narcissus cv. Professor Einstein, we isolated 23 previously known Amaryllidaceae alkaloids (1–23) of several structural types and one previously undescribed alkaloid, 7-oxonorpluviine. The chemical structures were identified by various spectroscopic methods (GC-MS, LC-MS, 1D, and 2D NMR spectroscopy) and were compared with literature data. Alkaloids which had not previously been isolated and studied for cytotoxicity before and which were obtained in sufficient amounts were assayed for their cytotoxic activity on a panel of human cancer cell lines of different histotype. Above that, MRC-5 human fibroblasts were used as a control noncancerous cell line to determine the general toxicity of the tested compounds. The cytotoxicity of the tested alkaloids was evaluated using the WST-1 metabolic activity assay. The growth of all studied cancer cell lines was inhibited by pancracine (montanine-type alkaloid), with IC50 values which were in the range of 2.20 to 5.15 µM.

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“…The Lycoris genus (Amaryllidaceae) consists of more than 20 species and is mainly distributed in the temperate woodlands of eastern Asia, with 17 (including one variety) distributed in China . The bulbs have been used as herbal medicines to treat laryngeal trouble, furuncle, carbuncle, mastitis, tympanitis, ulcers, suppurative wounds and poliomyelitis in China . Lycorine, one of the most common alkaloids in Lycoris spp., and related lycorine‐type alkaloids are believed to possess antiviral, anti‐inflammatory, anticancer, antifungal and antimalarial properties.…”

Section: Introductionmentioning

confidence: 99%

Discovery and characterisation of lycorine‐type alkaloids in Lycoris spp. (Amaryllidaceae) using UHPLC‐QTOF‐MS

Liao

et al. 2018

Phytochemical Analysis

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Introduction Lycorine, one of the most common alkaloids in Lycoris spp., is believed to possess pharmacological activity. Objective To discover and identify lycorine‐type alkaloids in the crude extracts of bulbs from six Lycoris spp. by ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry (UHPLC‐QTOF‐MS) detection. Methodology A qualitative analytical method with a data mining strategy was utilised. Based on the fragmentation patterns of standards investigated in positive tandem mass spectrometry (MS/MS) mode, the fragmentation rules of lycorine‐type alkaloids were summarised. These types of alkaloids were additionally classified as different subtypes based on structural features and MS/MS fragmentation patterns, and the diagnostic ions for characterisation of different subtypes of alkaloids were designated. Results Thirty‐seven lycorine type alkaloids, including 16 previously undescribed compounds, were efficiently screened out and tentatively identified from the crude extracts of six Lycoris spp. Lycoris sprengri may be a preferable species for studying or extracting lycorine‐type alkaloids because of elevated relative concentrations and highest diversity of alkaloids. Conclusion The UHPLC‐QTOF‐MS and MS/MS data‐mining strategy proved useful for the detection and tentative identification of lycorine‐type alkaloids in bulbs of Lycoris spp. and could be extended to other Amaryllidaceae genera. The consequent profiling of the lycorine‐type alkaloids will be useful in the quality control of raw materials of Lycoris species and the exploration of superior species.

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A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata

Abstract: Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg·mL-1 and CC50 values of 14.37, 4.79, and 80.12 μg·mL-1, respectively.

Cited by 22 publications

References 14 publications

Determination of allelopathic potentials in plant species in Sino-Japanese floristic region by sandwich method and dish pack method

Determination of allelopathic potentials in plant species in Sino-Japanese floristic region by sandwich method and dish pack method

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity

Discovery and characterisation of lycorine‐type alkaloids in Lycoris spp. (Amaryllidaceae) using UHPLC‐QTOF‐MS

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