A new amino amidine derivative from the wood-decaying fungus <i>Xylaria</i> cf. <i>cubensis</i> SWUF08-86

Sawadsitang, Sasiphimol; Suwannasai, Nuttika; Mongkolthanaruk, Wiyada; Ahmadi, Peni; McCloskey, Sirirath

doi:10.1080/14786419.2017.1405414

Cited by 10 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From stroma-derived cultures of Xylaria cf. cubensis, an amino-amindine, 2,5-diamino-N-(1-amino-1-imino-3methylbutan-2-yl)-pentamide (53), was discovered along with several diketopiperazines and furanones [80]. No antimicrobial or cytotoxic activities were found for this new compound.…”

Section: Benzenoids and Lactones From Xylariaceae (Fig 7)mentioning

confidence: 99%

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Becker

Stadler

2020

J Antibiot

View full text Add to dashboard Cite

The families Xylariaceae and Hypoxylaceae (Xylariales, Ascomycota) represent one of the most prolific lineages of secondary metabolite producers. Like many other fungal taxa, they exhibit their highest diversity in the tropics. The stromata as well as the mycelial cultures of these fungi (the latter of which are frequently being isolated as endophytes of seed plants) have given rise to the discovery of many unprecedented secondary metabolites. Some of those served as lead compounds for development of pharmaceuticals and agrochemicals. Recently, the endophytic Xylariales have also come in the focus of biological control, since some of their species show strong antagonistic effects against fungal and other pathogens. New compounds, including volatiles as well as nonvolatiles, are steadily being discovered from these ascomycetes, and polythetic taxonomy now allows for elucidation of the life cycle of the endophytes for the first time. Moreover, recently high-quality genome sequences of some strains have become available, which facilitates phylogenomic studies as well as the elucidation of the biosynthetic gene clusters (BGC) as a starting point for synthetic biotechnology approaches. In this review, we summarize recent findings, focusing on the publications of the past 3 years.

show abstract

Section: Benzenoids and Lactones From Xylariaceae (Fig 7)mentioning

confidence: 99%

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Becker

Stadler

2020

J Antibiot

View full text Add to dashboard Cite

show abstract

“…Previous works indicated the putative antimicrobial activity of microorganisms isolated from decayed wood [11][12][13][14], which fuelled the present analyses of the microbial inhabitants from this non-traditional resource. This study is focused on the detection of genes encoding PKSs and NRPSs, which are involved in the production of different secondary metabolites, such as antibiotics, and the subsequent validation by means of competitive bioassays.…”

Section: Discussionmentioning

confidence: 67%

“…These complex biological interactions create a highly interesting environmental niche in which to look for microorganism with potential industrial applications in red (e.g., antibiotics, drugs) and white (e.g., enzymes) biotechnologies. Although this niche has not been deeply investigated as a source of antimicrobial compounds, some wood-decaying fungi, or fungi associated with them, present antimicrobial activities [11][12][13]. Besides, different bioactive potential has been described in microorganisms isolated from decaying wood, such as the antimicrobial biosynthetic capacity in Paraburkholderia sp., or anti-insect activity from alkaloids isolated from Penicillium species [14,15].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Microbial Diversity in Decayed Wood from a Spanish Forest: An Environmental Source of Industrially Relevant Microorganisms

et al. 2022

View full text Add to dashboard Cite

Rotting wood is inhabited by a large diversity of bacteria, fungi, and insects with complex environmental relationships. The aim of this work was to study the composition of the microbiota (bacteria and fungi) in decaying wood from a northwest Spanish forest as a source of industrially relevant microorganisms. The analyzed forest is situated in a well-defined biogeographic area combining Mediterranean and temperate macrobioclimates. Bacterial diversity, determined by metagenome analyses, was higher than fungal heterogeneity. However, a total of 194 different cultivable bacterial isolates (mainly Bacillaceae, Streptomycetaceae, Paenibacillaceae, and Microbacteriaceae) were obtained, in contrast to 343 fungal strains (mainly Aspergillaceae, Hypocreaceae, and Coniochaetaceae). Isolates traditionally known as secondary metabolite producers, such as Actinobacteria and members of the Penicillium genus, were screened for their antimicrobial activity by the detection of antibiotic biosynthetic clusters and competitive bioassays against fungi involved in wood decay. In addition, the ability of Penicillium isolates to degrade cellulose and release ferulic acid from wood was also examined. These results present decaying wood as an ecologically rich niche and a promising source of biotechnologically interesting microorganisms.

show abstract

“…The Xylaria is a large genus in the fungal family Xylariaceae, which is known to be a rich source of secondary metabolites-e.g., phenolic acids, flavonoids, alkaloids, steroids, polyketides, amino amidine, cytochalasins, ergot alkaloids, ergosterol, indole alkaloids and etc. [9][10][11][12]. Over the last few decades, several new bioactive compounds have been regularly discovered from Xylaria species and found to exhibit effective antimicrobial, antifungal, anti-inflammatory, antioxidant and anticancer activities [13,14].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Cytotoxicity against Cancer Cell Lines of the Extracts from Novel Xylaria Species Associated with Termite Nests and LC-MS Analysis

et al. 2021

Self Cite

View full text Add to dashboard Cite

Xylaria species associated with termite nests or soil have been considered rare species in nature and the few which have been reported upon have been found to act as a rich source of bioactive metabolites. This study evaluated 10 ethyl acetate extracts of five new Xylaria species associated with termite nests or soil for their antioxidant activity, and cytotoxicity against different cancer and normal cell lines. DPPH and ABTS radical scavenging activities of the extracts demonstrated strong capacity with low IC50 values. The highest observed activities belonged to X. vinacea SWUF18-2.3 having IC50 values of 0.194 ± 0.031 mg/mL for DPPH assay and 0.020 ± 0.004 mg/mL for ABTS assay. Total phenolic content ranged from 0.826 ± 0.123 to 3.629 ± 0.381 g GAE/g crude extract which correlated with antioxidant activities. The high total phenolic content could contribute to the high antioxidant activities. Cytotoxicity was recorded against A549, HepG2, HeLa and PNT2 and resulted in broad spectrum to specific activity depending on the cell lines. The highest activities were observed with X. subintraflava SWUF16-11.1 which resulted in 11.15 ± 0.32 to 13.17 ± 2.37% cell viability at a concentration of 100 µg/mL. Moreover, LC-MS fingerprints indicated over 61 peaks from all isolates. There were 18 identified and 43 unidentified compounds compared to mass databases. The identified compounds were from various groups of diterpenoids, diterpenes, cytochalasin, flavones, flavonoids, polyphenols, steroids and derivatives, triterpenoids and tropones. These results indicate that Xylaria spp. has abundant secondary metabolites that could be further explored for their therapeutic properties.

show abstract

A new amino amidine derivative from the wood-decaying fungus Xylaria cf. cubensis SWUF08-86

Cited by 10 publications

References 26 publications

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Characterization of Microbial Diversity in Decayed Wood from a Spanish Forest: An Environmental Source of Industrially Relevant Microorganisms

Antioxidant Activity and Cytotoxicity against Cancer Cell Lines of the Extracts from Novel Xylaria Species Associated with Termite Nests and LC-MS Analysis

Contact Info

Product

Resources

About