A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth

Ahmad, Islamudin; Ambarwati, Neneng Siti Silfi; Elya, Berna; Omar, Hasmahzaiti; Mulia, Kamarza; Yanuar, Arry; Negishi, Osamu; Im, Abdul Mun

doi:10.4103/2221-1691.260398

Cited by 13 publications

(10 citation statements)

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“…Phytochemical screening revealed that Peperomia pellucida contains glycosides, F I G U R E 1 Structures of some drugs used for managing hypertension anthraquinones, terpenoids and tannins (Saputri et al, 2015). Major compounds isolated from Peperomia pellucida are quercetin, pellucidin A, peperomia A,B,C and E, 2,3,5-trimethoxy-9-(12,14,15-trimeth oxybenzyl)-1H-indene (Ahmad, 2019). Saputri et al (2015) reported strong inhibitory activities of Peperomia pellucida on ACE with IC 50 value of 7.17 μg/mL.…”

Section: Peperomia Pellucidamentioning

confidence: 99%

“…They relax and widen narrowed blood vessels (Minesh & Chakraborthy, 2021). Angiotensin converting enzyme (ACE) inhibitors help blood vessels to relax and open up, consequently lowering the blood pressure (Ahmad et al, 2019). Angiotensin (II) receptor blocker prevents angiotensin from binding to its receptor, thereby preventing blood vessels from being constricted (Moore et al, 2021).…”

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confidence: 99%

“…Several spices have been reported to be rich in antioxidants and by extension have demonstrated antihypertensive and cardio protective potentials in both primary and secondary hypertension (Ciumărnean et al, 2020). Angiotensin converting enzyme inhibitor compounds isolated from spices include chlorogenic acid, hydroxycinnamic acid, gingerol, capsaicin, curcumin, eugenol, gallic acid, vanillic acid, rutin, apigenin, epicatechin, linalool, β-ocimene, α-farnesenerutin, quercetin, ellagic acid, paradol, pellucidin A, peperomia, and β-phellandrene (Adefegha et al, 2018;Ahmad et al, 2019;Ranilla et al, 2010). Hence, the research provides comprehensive list and mechanism of action of spices commonly used in Africa with proven anti-hypertensive effect (Figure 1).…”

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confidence: 99%

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A review of some common African spices with antihypertensive potential

Adeoye

Joel

Igunnu

et al. 2021

Journal of Food Biochemistry

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Hypertension is the most common non-communicable disease, with about 1.28 billion hypertensive people worldwide. It is more prevalent in men than women and more common in the elderly. Hereditary, age, obesity, lifestyle, diet, alcohol, and chronic metabolic diseases are the major risk factors of hypertension. Treating hypertension is a complex process as there are several mechanisms responsible for its pathogenesis; hence, a combination of several drugs is used for managing hypertension. Drugs used in managing hypertension are expensive and often come with associated side effects; thus, there is need for alternative means of managing this life-threatening disease. These drugs do not achieve the recommended blood pressure target in most people; more so majority of people with hypertension do not follow the treatment regimen religiously. Some Africans have been reported to become normotensive as a result of dietary consumption of spices. Several spices have been used over the years in Africa to manage hypertension. The aim of this review is to evaluate the ethnomedicinal use, bioactive phytochemical composition, bioactive compounds present, and pharmacological applications of spices commonly used in Africa for managing hypertension. Most of the plants used contained polyphenols, flavonoids, tannins, anthraquinone, flavonoids, cardiac glycosides, and saponins. Dietary supplementation of Xylopia aethiopica and other spices in diet have been proven to significantly reduced plasma angiotensin-I-converting enzyme (ACE) than simvastatin (the reference drug). Toxicological, histological, and hematological evaluation revealed that acute and chronic consumption of most of these spices are safe. Studies have also revealed that some of the spices can be used as alternative therapy alongside usual antihypertensive medications. Practical implication:The prevalent rate of hypertension is on the increase in both the developed and developing countries. People often skip medication due to their busy schedule and anti-hypertensive potential side effects; however, this is not the case with food/spices as most people consumed them daily. Deliberate, right combinations and consistent incorporation of spices with proven anti-hypertensive potential into our diet may be of great benefit in normalizing blood pressure and mitigate other complications on the heart and vital organs.Hypertension or elevated blood pressure means the persistent force of blood against the artery wall leading to increase in blood pressure. According to World Health Organisation (WHO, 2021), blood pressure on two different days with both days exceeding 140/90 mmHg is classified as hypertension. The first (higher) number is the systolic, which is the blood pressure when the heart contracts, while the second (lower number) is the diastolic, which is the blood pressure when the heart relaxes (Ondimu et al., 2019). It is usually measured using upper arm cuff; however wrist devices are used for obese persons with extreme size of the arm (Nerenberg et al., 2018). Accordi...

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Section: Peperomia Pellucidamentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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A review of some common African spices with antihypertensive potential

Adeoye

Joel

Igunnu

et al. 2021

Journal of Food Biochemistry

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“…Many biological activity studies have been successfully conducted to reveal the potential of P. pellucida in treating diseases, including antihypertensive, anti-inflammatory, antipyretic, analgesic, antibacterial, antiamoeba, antioxidant, gastroprotective, and other pharmacological activities (Ahmad et al, 2019;Fakayode et al, 2021;Idris et al, 2016;Ng et al, 2021;Rojas-Martínez et al, 2013;Uwaya et al, 2021). The results are also supported by the fact that this plant contains phytochemical compounds responsible for pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Peperomia pellucida (L.) Kunth herbs: A comprehensive review on phytochemical, pharmacological, extraction engineering development, and economic promising perspectives

Ahmad¹,

Hikmawan²,

Mun’im³

et al. 2022

J App Pharm Sc

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Peperomia pellucida (L.) Kunth belongs to the Piperaceae family and has long been used empirically as a traditional medicine by the communities of Indonesia, the Philippines, India, Nigeria, Brazil, and other countries. The herb of P. pellucida has chemical constituents with potential activities such as analgesic, antipyretic, anti-inflammatory, antidiabetic, antigout, antihypertensive (angiotensin-converting enzyme inhibitors), antioxidant, and antibacterial, as well as activities such as a sunscreen. Unfortunately, this plant has not been utilized as a source of raw material for herbal medicines commercially. So far, this plant has been considered a weed by local farmers (mainly oil palm plantations in Indonesia). This narrative review aims to comprehensively overview P. pellucida herbs as a potential natural resource for herbal medicine by looking from different perspectives. This review article highlights some perspectives on this herb, including plant description and origins, phytochemistry, pharmacology and toxicology, extraction technique development, and its prospect as an economic natural resource of herbal medicines.

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“…[15] The leaves of Carica papaya have been reported to possess antioxidant, anti-hypertensive, anti-inflammatory, antimicrobial, antifungal, anti-tumor, antimalarial, immunomodulatory activity, anti-ulcer activity, anti-sickling activity and are also a remedy for dengue fever. [16,17] The leaves of papaya are rich in various active components such as papain, chymopapain, cystatin, tocopherol, ascorbic acid, flavonoids, cyanogenic glucosides and glucosinolates. [18] Here, we have reported the effect of isolated fraction from methanol extract of papaya leaves on Ab aggregates as well as in differentiated PC12 derived neurons.…”

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Methanolic Extract of Papaya Leaves Shows Neuroprotective Effect

et al. 2017

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Alzheimer's disease (AD) is one of the most common neurodegenerative diseases among elderly people around the world. The main pathophysiological pathway of AD is the misfolding of amyloid‐beta (Aβ) peptide into fibrillar aggregates that result in formation of neurofibrillary tangles and severe brain damages. Carica papaya has been used as traditional herbal medicine against various diseases in India and China. In this manuscript, we have explored the effectiveness of tertiary butyl methyl ether fraction from methanol extract of dried papaya leaves as a neuroprotective candidate. We have performed Thioflavin T (ThT) assay and docking studies to perceive the inhibition of Aβ‐42 aggregation, a hallmark of AD. This fraction is non‐cytotoxic in nature and shows neuroprotection against anti‐Nerve Growth Factor (anti‐NGF) induced cytotoxicity in PC12 derived neurons and confers significant stability to intracellular microtubule.

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A new angiotensin-converting enzyme inhibitor from Peperomia pellucida (L.) Kunth

Cited by 13 publications

References 1 publication

A review of some common African spices with antihypertensive potential

A review of some common African spices with antihypertensive potential

Peperomia pellucida (L.) Kunth herbs: A comprehensive review on phytochemical, pharmacological, extraction engineering development, and economic promising perspectives

Methanolic Extract of Papaya Leaves Shows Neuroprotective Effect

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