A new animal model for abdominal aortic aneurysms: Initial results using a multiple-wire stent

Whitbread, T.; Birch, Pattie; Rogers, S.; Majeed, Ali W.; Rochester, J.; Beard, Jonathan; Gaines, Peter A.

doi:10.1016/s1078-5884(96)80141-9

Cited by 27 publications

(13 citation statements)

References 8 publications

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“…Infusion of elastase in an isolated segment of the aorta to create an aneurysm model has been reported in rats [5,6], but again, similar results could hardly be effectively reproduced in large animals [7][8][9]. The most effective methods to develop an aneurysm model for larger animals have been use of an anterior patch and use of a pouch made of autogenous fascia, vein, jejunum, or synthetic polyethylene terephthalate [10][11][12][13].…”

Section: Original Researchmentioning

confidence: 82%

Development of a Symmetric Canine Abdominal Aortic Aneurysm Model With Clinical Relevance for Endovascular Graft Studies

Shi²,

Bhattacharya³

et al. 2001

Journal of Investigative Surgery

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This study was designed to develop a large-animal model to study and validate transluminally placed endovascular grafts and related techniques for treating abdominal aortic aneurysms with minimal trauma. In four dogs, a segment of infrarenal abdominal aorta was dissected and an endarterectomy was performed through an aortotomy to remove the entire intima of this controlled aortic segment. The opening was patched with chemically processed bovine pericardium, and an identical patch was applied after aortotomy of the opposite side of the aorta. Aortic diameter and flow were measured before and after the procedure. Angiograms were obtained just before retrieval. All dogs recovered quickly with no complications. Aortic diameter increased approximately 2.7-fold. Aneurysm size and shape remained stable until the end of the experiments at 4 or 8 weeks. Gross and histologic studies for 4- and 8-week specimens were similar. Factor VIII/von Willebrand factor staining showed complete reendothelialization of the endarterectomized wall, with a moderate degree of intimal hyperplasia. The patch material retained its acellular nature and its surface was covered with thrombus or fibrinous material mixed with blood cells and inflammatory cells. Thus, this model is feasible and suitable for endovascular graft healing studies.

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Section: Original Researchmentioning

confidence: 82%

Development of a Symmetric Canine Abdominal Aortic Aneurysm Model With Clinical Relevance for Endovascular Graft Studies

Shi²,

Bhattacharya³

et al. 2001

Journal of Investigative Surgery

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“…An independent group reported good renal artery patency, renal perfusion pressure and kidney function after placement of an uncovered self-expanding Wallstent (Schneider AG, Bulach, Switzerland) in the abdominal aorta across renal artery origins [100,189]. It was supported that despite covering renal artery origins with a Wallstent during EVAR, these arteries remained widely patent with no evidence of renal infarction of microemboli formation [100,189].…”

Section: Experimental Models For Endovascular Aaa Repair (Evar)mentioning

confidence: 99%

“…The interposition graft model has been reproduced in dogs, pigs and sheep, with grafts made from crimped woven Dacron [93][94][95][96][97], biomedical grade elastomeric polyurethane [95], autologous jugular vein [98] or gastric serosa patches [99] and segments of glutaraldehyde-treated bovine internal jugular vein [100] to mimic an aneurysm. Another disadvantage is that these aneurysms do not show progressive enlargement thus differing from human AAAs [93][94][95][96][97][98][99][100]. A disadvantage of this model noted in all animals is the presence of moderate to severe fibrous reaction around the artificial aneurysm and in the sac wall.…”

Section: Interposition Graft Modelmentioning

confidence: 99%

Experimental Models of Abdominal Aortic Aneurysms: An Overview

Paraskevas

Mikhailidis²,

Perrea³

2008

CPD

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In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons.The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.

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“…created a model by interpositioning a fusiform segment of glutaraldehyde-tanned bovine internal jugular vein into the infrarenal aortas of large white pigs [91]. The resulting aneurysm had an aorta to aneurysm diameter ratio of 1:2.…”

Section: Animal Modelsmentioning

confidence: 99%

Experimental Models of Abdominal Aortic Aneurysms

Tsui¹

2010

TOCMJ

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Despite being a leading cause of death in the West, the pathophysiology of abdominal aortic aneurysms (AAA) is still incompletely understood. Pharmacotherapy to reduce the growth of small AAAs is limited and techniques for repairing aneurysms continue to evolve. Experimental models play a key role in AAA research, as they allow a detailed evaluation of the pathogenesis of disease progression. This review focuses on in vivo experimental models, which have improved our understanding of the potential mechanisms of AAA development and contributed to the advancement of new treatments.

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A new animal model for abdominal aortic aneurysms: Initial results using a multiple-wire stent

Cited by 27 publications

References 8 publications

Development of a Symmetric Canine Abdominal Aortic Aneurysm Model With Clinical Relevance for Endovascular Graft Studies

Development of a Symmetric Canine Abdominal Aortic Aneurysm Model With Clinical Relevance for Endovascular Graft Studies

Experimental Models of Abdominal Aortic Aneurysms: An Overview

Experimental Models of Abdominal Aortic Aneurysms

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