2021
DOI: 10.1080/14786419.2021.1976175
|View full text |Cite
|
Sign up to set email alerts
|

A new anti-tumor cytotoxic triterpene from Ganoderma lucidum

Abstract: Ganoderma lucidum (G. lucidum) is a famous medicinal fungus used as a traditional medicine for generations in China. Among bioactivities that G. lucidum possesses, the anti-tumor effect has aroused extensive interests. In this study, one new triterpene (1) was isolated from 90 % ethanol extract of the dried fruiting bodies of G. lucidum. Its structure was determined based on the analysis of its spectroscopic data, including 1D and 2D NMR and MS spectra.Furthermore, 1 elicited moderate anti-tumor activities (IC… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0
1

Year Published

2022
2022
2024
2024

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 14 publications
(6 citation statements)
references
References 11 publications
0
5
0
1
Order By: Relevance
“…In the same year, a new triterpene was isolated from the ethanolic extract of the fruiting bodies of Ganoderma lucidum . This compound exerted moderate antitumor effects (IC 50 values of 15.38 ± 0.34 and 18.61 ± 0.55 μM against A549 and HepG2, respectively) compared to cisplatin [ 40 ]. In addition, both new and previously known compounds with nor-triterpenoid structures were isolated from the fruiting bodies of Ganoderma lucidum .…”
Section: Resultsmentioning
confidence: 99%
“…In the same year, a new triterpene was isolated from the ethanolic extract of the fruiting bodies of Ganoderma lucidum . This compound exerted moderate antitumor effects (IC 50 values of 15.38 ± 0.34 and 18.61 ± 0.55 μM against A549 and HepG2, respectively) compared to cisplatin [ 40 ]. In addition, both new and previously known compounds with nor-triterpenoid structures were isolated from the fruiting bodies of Ganoderma lucidum .…”
Section: Resultsmentioning
confidence: 99%
“…In a recent study conducted by Cao et al, one new triterpene was isolated from G. lucidum and it exhibited remarkable cytotoxic effects A549 (IC 50 : 15.38 µM) and HepG2 (IC 50 : 18.61 µM cell lines) [61]. In contrast to the results, ganodrenol derivatives, along with three known nor-triterpenoids were isolated from G. lucidum and displayed no cytotoxic effect on t LOVO, MCF-7, and RAW264.7 cells [62].…”
Section: Anticancer and Cytotoxicity Effectsmentioning
confidence: 99%
“…Ganoderma, commonly represent a group of medicinal mushrooms revered for their extensive history in traditional medicine and their rich array of bioactive compounds (Martínez-Montemayor et al, 2019; He et al, 2022) [18,11] including polysaccharides (Zhang et al, 2019) [29] , triterpenes (Such as ganoderic acids) (Yangchum et al, 2022) [27] , peptides, alkaloids, flavonoids, lipids, steroids, glycosides, saponins, anthraquinone, anthocyanins, tannins and phenolic compounds (Sindhu et al, 2021) [22] . Ganoderma has so many therapeutic properties such as antioxidant, immunity booster, anti-inflammatory (Wen et al, 2022) [24] , viral infections (Cor Andrejc et al, 2022) [9] , antidiabetes, anticancerous properties (Cao et al, 2022;Wu et al, 2022) [5,25] , pneumatoprotective including asthma and bronchitis (Wang et al, 2020) [23] , high blood pressure and high cholesterol, kidney disease, altitude sickness, chronic fatigue syndrome (CFS), trouble sleeping (Insomnia), stomach ulcers, poisoning, herpes pain, reducing stress and antifatigue. For millennia this mushroom have been esteemed in various cultures, particularly in traditional Chinese medicine (El-Sheikha et al, 2022) [10] and other Asian healing practices, due to their purported health-promoting properties and has gained attention in diabetes management due to its potential metallo protein actions.…”
Section: Introductionmentioning
confidence: 99%