A New Antibody, Anti‐Fy3, in the Duffy Blood Group System

Abstract

A new antibody that reacts with all human bloods except those of type Fy(a-b-) has been named anti-Fy3. It is believed to detect a previously unknown bloodgroup antigen, which is possibly a precursor of Fy& and Fyb. Key Words Duffy blood groups New antibodyFollowing discoveries by CUTBUSH, MOLLISON and PARKIN [3] and by IKIN, MOURANT, PETTENKOFER and BLUMENTHAL [4], the Duffy blood groups were established as a system involving two antigens, Fya and Fyb, identified b y two antibodies, anti-Fya and anti-Fyb. The existence of Fy, allelic to the genes Fya and Fyb, was postulated by SANGER, RACE and JACK [8] t o explain the occurrence of the

Anti-Fy5, an Antibody Disclosing a Probable Association between the Rhesus and Duffy Blood Group Genes

“…The results of Albrey et al [1], and our own data, indicate that anti-Fy3 and -Fy5 sera are not simply mixtures of anti-Fya and -Fyb but that different Duffy-related antigens are being recognized. At the same time, the involvement of Rhnun with Fy5, but not with Fy3, establishes that these antigens also are distinctive.…”

“…Neither of these suggestions will readily fit the data obtained with the anti-Fy5 blood sample If the conclusion that Fy5 arises by gene inter action is correct then it follows that Fy genes must be present in the Caucasian sample. The lack of expression in this case may, therefore, be an effect of modifying genes at the Duffy locus, a possibility already considered by Albrey et al [1]. The phenotype Fyx described by Chown et al [3] is characterized by a weak reaction with anti-Fy".…”

An Alberta Cree Indian with a Rare Duffy Antibody, Anti-Fy 3

“…The presence of the antigen Fyx in the family was surprising simply because of the rarity of the corresponding allele in any population so far tested, though Fyx, which presents itself as very weak Fyb, may have been overlooked in perhaps the majority of population studies. The titration scores of table I indicate that the Fy3 antigen, which must be produced by the Duffy complex locus [1], is somewhat weaker than normal in FyxFyx and weaker still in FyFyx people.…”

Fy(a-b-) Phenotype in Czechoslovakia

“…It is not easy to assess dosage of Fya or Fyb antigens since most grouping reagents are active by the IgG antiglobulin technique, but in any case the samples could not be collected at one time and were never strictly comparable. The reports on anti-Fy3 indicate that cells known to be heterozygous for Fy react as strongly as those without Fy [1,3].…”

“…Homozygous FyxFyx individuals have been reported [4,6] and may, in the past, have been confused with the Fy(a-b-) phenotype, but have been since shown to be Fy3(+) [1].…”