A new antioxidant flavone glycoside from <i>Scutellaria baicalensis</i> Georgi

Wang, Meng-Hua; Li, Lin-Zhen; Sun, Jianbo; Wu, Feihua; Liang, Jing‐Yu

doi:10.1080/14786419.2014.931391

Cited by 27 publications

(8 citation statements)

References 7 publications

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“… Classification, food sources, and chemical structure of flavonoids [ 4 , 10 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. …”

Section: Figurementioning

confidence: 99%

Flavonoids in Cancer Metastasis

Líšková

Koklesová

Samec

et al. 2020

Cancers

137

128

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Metastasis represents a serious complication in the treatment of cancer. Flavonoids are plant secondary metabolites exerting various health beneficiary effects. The effects of flavonoids against cancer are associated not only with early stages of the cancer process, but also with cancer progression and spread into distant sites. Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-β and other contributors of the complex process of metastatic spread. Moreover, flavonoids modulated also the expression of genes associated with the progression of cancer and improved inflammatory status, a part of the complex process involved in the development of metastasis. Flavonoids also documented clear potential to improve the anti-cancer effectiveness of conventional chemotherapeutic agents. Most importantly, flavonoids represent environmentally-friendly and cost-effective substances; moreover, a wide spectrum of different flavonoids demonstrated safety and minimal side effects during long-termed administration. In addition, the bioavailability of flavonoids can be improved by their conjugation with metal ions or structural modifications by radiation. In conclusion, anti-cancer effects of flavonoids, targeting all phases of carcinogenesis including metastatic progression, should be implemented into clinical cancer research in order to strengthen their potential use in the future targeted prevention and therapy of cancer in high-risk individuals or patients with aggressive cancer disease with metastatic potential.

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“… Classification, food sources, and chemical structure of flavonoids [ 4 , 10 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. …”

Section: Figurementioning

confidence: 99%

Flavonoids in Cancer Metastasis

Líšková

Koklesová

Samec

et al. 2020

Cancers

137

128

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“…Scutellaria baicalensis (SB) (Huangqin) is a widely used TCM (Mehlhorn et al, 2014), which was firstly described in “Shen Nong Ben Cao Jing” (Yuan et al, 2015). Modern pharmacological studies have depicted its positive effects in neuroprotection (Yune et al, 2009; Miao et al, 2014), anti-cancer (Ye et al, 2002; Sato et al, 2013), anti-inflammation (Huang et al, 2006; Kim et al, 2009; Yoon et al, 2009), anti-oxidation (Gabrielska et al, 1997; Huang et al, 2006; Wang et al, 2014), anti-bacteria, and anti-virus (Zandi et al, 2013; Shi et al, 2016). Flavonoids including baicalin, baicalein, wogonin, oroxylin A-7- O -glucuronopyranoside, and oroxylin A are the major chemical components in SB (Lee et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis

et al. 2019

Front. Pharmacol.

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Literary evidence depicts that aggregated β-amyloid (Aβ) leads to the pathogenesis of Alzheimer’s disease (AD). Although many traditional Chinese medicines (TCMs) are effective in treating neurodegenerative diseases, there is no effective way for identifying active compounds from their complicated chemical compositions. Instead of using a traditional herbal separation method with low efficiency, we herein apply UHPLC-DAD-TOF/MS for the accurate identification of the active compounds that inhibit the fibrillation of Aβ (1-42), via an evaluation of the peak area of individual chemical components in chromatogram, after incubation with an Aβ peptide. Using the neuroprotective herbal plant Scutellaria baicalensis (SB) as a study model, the inhibitory effect on Aβ by its individual compounds, were validated using the thioflavin-T (ThT) fluorescence assay, biolayer interferometry analysis, dot immunoblotting and native gel electrophoresis after UHPLC-DAD-TOF/MS analysis. The viability of cells after Aβ (1-42) incubation was further evaluated using both the tetrazolium dye (MTT) assay and flow cytometry analysis. Thirteen major chemical components in SB were identified by UHPLC-DAD-TOF/MS after incubation with Aβ (1–42). The peak areas of two components from SB, baicalein and baicalin, were significantly reduced after incubation with Aβ (1–42), compared to compounds alone, without incubation with Aβ (1–42). Consistently, both compounds inhibited the formation of Aβ (1–42) fibrils and increased the viability of cells after Aβ (1–42) incubation. Based on the hypothesis that active chemical components have to possess binding affinity to Aβ (1–42) to inhibit its fibrillation, a new application using UHPLC-DAD-TOF/MS for accurate identification of inhibitors from herbal plants on Aβ (1–42) fibrillation was developed.

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“…Therefore, a safer and more effective drug is urgently needed to treat OA. Wogonoside, an individual component extracted from Scutellaria baicalensis Georgi, exhibits anti-oxidant, anti-tumor, anti-thrombotic, and anti-inflammatory effects [ 23 – 26 ]. Wogonoside not only affects the translation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) but also inhibits lipopolysaccharide (LPS)-induced TNF-α and IL-6 expression in RAW264.7 cells [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis

et al. 2017

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The inflammatory environment is correlated with extracellular matrix (ECM) degradation and chondrocyte hypertrophy in the development of osteoarthritis (OA). Previous studies have reported the anti-inflammatory effects of wogonoside in several diseases. In the present study, we investigated the protective effects of wogonoside in relation to the development of OA and delineated the potential mechanism. In vitro, wogonoside decreased the production of pro-inflammatory cytokines like Nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6). It also inhibited the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) both at gene and protein levels. Wogonoside also inhibited hypertrophy and the generation of vascular endothelial growth factor (VEGF) in interleukin-1β (IL-1β)-induced chondrocytes. Moreover, wogonoside promoted the expression of anabolic factors Sox-9, type two collagen and aggrecan while inhibiting the expression of catabolic factors such as matrix metalloproteinases (MMPs) and thrombospondin motifs 5 (ADAMTS-5) in mouse chondrocytes. Mechanistically, we found that wogonoside inhibited nuclear factor kappa B/ hypoxia-inducible factor two alpha (NF-κB/HIF-2α) activation via the phosphatidylinositol 3 kinase (PI3K) /AKT pathway. The protective effects of wogonoside were also observed in vivo and the pharmacokinetic results of wogonoside indicated that good systemic exposure was achievable after oral administration of wogonoside. In conclusion, our stduy demonstrates that wogonoside attenuates IL-1β-induced ECM degradation and hypertrophy in mouse chondrocytes via suppressing the activation of NF-κB/HIF-2α by the PI3K/AKT pathway. Moreover, wogonoside ameliorates OA progression in vivo, indicating that wogonoside may serve as a promising therapeutic agent for the treatment of OA.

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A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi

Cited by 27 publications

References 7 publications

Flavonoids in Cancer Metastasis

Flavonoids in Cancer Metastasis

The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis

Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis

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