The COVID-19 pandemic has caused unprecedent negative impacts on our society, however, evidences show a reduction of anthropogenic pressures on the environment. Due to the high importance of environmental conditions on human life quality, it is crucial to model the impact of COVID-19 lockdown on environmental conditions. Consequently, the objective of this study was to model the impact of COVID-19 lockdown on the urban surface ecological status (USES). To this end, the Landsat-8 images of Milan for three pre-lockdown dates (Feb 13, 2018 (MD1), April 18, 2018 (MD2) and Feb 3, 2020 (MD3)) and one date over the lockdown (April 14, 2020 (MD4)), and Wuhan for three pre-lockdown dates (Dec 17, 2017 (WD1), March 23, 2018 (WD2) and Dec 7, 2019 (WD3)) and one lockdown date (Feb 9, 2020 (WD4)) were used. First, pressure-state-response (PSR) framework parameters including index-based built-up index (IBI), vegetation cover (VC), vegetation health index (VHI), land surface temperature (LST) and Wetness were calculated. Second, by combining the PSR framework parameters based on comprehensive ecological evaluation index (CEEI), the USES were modeled on different dates. Thirdly, the USES during the COVID-19 lockdown was compared with the USES for pre-lockdown. The mean (standard deviation) of CEEI for Milan on MD1, MD2, MD3 and MD4 were 0.52 (0.12), 0.60 (0.19), 0.57 (0.13) and 0.45 (0.16), respectively. Also, these values for Wuhan on WD1, WD2, WD3 and WD4 were 0.63 (0.14), 0.67 (0.15), 0.60 (0.13) and 0.57 (0.13), respectively. Due to the lockdowns, the mean CEEI of built-up, bare soil and green spaces for Milan and Wuhan decreased by [0.18, 0.02, 0.08], [0.13, 0.06, 0.05], respectively. During the lockdown period, the USES improved substantially due to the reduction of anthropogenic activities in the urban environment.