2019
DOI: 10.1111/jocd.13192
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A new approach in the treatment of pediatric hypertrophic burn scars: Tixel‐associated topical triamcinolone acetonide and 5‐fluorouracil delivery

Abstract: Background: Pediatric hypertrophic burn scars are challenging to treat due to their widespread nature and pain associated with the treatment. Intralesional triamcinolone acetonide (TAC) injection with or without 5-fluorouracil (5FU) is considered first-line treatment for severe hypertrophic scars. The pain associated with the procedure, the uneven topography, and epidermal atrophy, all limit the application of this treatment modality. Aims: We sought to evaluate the clinical effectiveness and safety profile of… Show more

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Cited by 25 publications
(25 citation statements)
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“…When Tixel® is used over the exposed dermis, augmented results can be achieved. (4) TMFI-assisted drug delivery: Tixel, known to improve drug delivery [16], has already been utilized in the treatment of several medical conditions, including hypertrophic scars [17], acne [18], and rosacea [19]. Therefore, combining the esthetic thermomechanical effect with different cosmeceutical or drug delivery might augment the results.…”
Section: Discussionmentioning
confidence: 99%
“…When Tixel® is used over the exposed dermis, augmented results can be achieved. (4) TMFI-assisted drug delivery: Tixel, known to improve drug delivery [16], has already been utilized in the treatment of several medical conditions, including hypertrophic scars [17], acne [18], and rosacea [19]. Therefore, combining the esthetic thermomechanical effect with different cosmeceutical or drug delivery might augment the results.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, TMA could be suitable for sensible populations. In a retrospective study, pediatric hypertrophic burn scars were treated with Tixel for transdermal delivery of a topical solution containing triamcinolone and 5FU 20.…”
Section: Discussionmentioning
confidence: 99%
“…TMFI-mediated thermal disruption of the skin barrier has been explored in vitro and in vivo for hydrophilic drugs that poorly penetrate the intact skin. Evaluated drugs include verapamil hydrochloride, diclofenac sodium, botulinum toxin A, and ALA [10][11][12][13]18]. A recent study by Shavit and Dierickx determined skin surface PpIX fluorescence in normal skin after TMFI, combined with commercially available photosensitizers in different concentrations and vehicle formulations [13].…”
Section: Discussionmentioning
confidence: 99%
“…Thermo-mechanical fractional injury (TMFI) is a relatively new technique that by the protrusion of pyramidshaped, titanium covered micro-tips, conducts heat to the skin, generating an array of fractional microscopic vertical columns of thermal injury [10,11]. TMFI has previously been explored for cutaneous uptake of hydrophilic drugs, such as verapamil, diclofenac sodium, 5-fluorouracil, and magnesium ascorbyl phosphate, after TMFI exposure [12][13][14]. In a recent study, TMFI pretreatment enhanced PpIX fluorescence at the skin surface following incubation with 20% ALA gel [14].…”
Section: Introductionmentioning
confidence: 99%