A new approach to migraines - A review of rimegepant; its merits, synthesis, and pharmacological characteristics

Abstract

Migraines in the modern day represent a significant problem, however, the current treatment options come with significant risks. This paper reviews rimegepant, its pharmacological characteristics, and possible synthetic pathways, focusing on ease of synthesis, green chemistry, and scalability. The review reveals a biocatalytic approach to be a promising candidate for industrial scale-up with relatively mild conditions.