It is well-known that one of the reasons for reducing the head of a centrifugal pump, when trimming its impeller, is the reduction of the slip factor. There are various methods used to determine it, but there is lack of information on whether they are applicable in case that a pump with a trimmed impeller operates. In the present work, a comparative experimental study concerning the applicability of some of the methods used to determine the slip factor, on two centrifugal pumps with different specific speed of rotation, is performed. Based on the experimental data, CFD models of the impellers of the two pumps have been validated and a numerical simulation study concerning the change of the slip factor during trimming, has also been performed. The impact of the rate of impeller trimming on the the slip factor variation has also been established. Based on the results found, concerning the performed numerical study, equations describing the relationship between the slip factor and the rate of trimming of the studied pumps are obtained.