A new approach to pharmacological effects on ciliary beat frequency in cell cultures—exemplary measurements under Pelargonium sidoides extract (EPs 7630)

Clinical Efficacy and Safety of Liquid Pelargonium sidoides Preparation (EPs 7630) in Children with Acute Non-Streptococcal Tonsillopharyngitis

“…of the preexisting acute tonsillopharyngitis due to the antiviral, antibacterial and immunomodulatory effects of EPs 7630 reported earlier (6)(7)(8)(9)(10)(11)(12)(13)(14). These findings also confirm the safety results of the formerly published clinical trial of EPs 7630 in children with acute tonsillopharyngitis (24).…”

“…Furthermore, EPs 7630 (EPs ® 7630 is the active ingredient of the product Umckaloabo ® (ISO-Arzneimittel, Ettlingen, Germany)), a herbal drug preparation from the roots of Pelargonium sidoides, has been shown to exhibit antiviral (6)(7)(8), antibacterial (9) as well as modulating and stimulating effects on the non-specific immune system (9)(10)(11), which are based on inhibition of bacterial adhesion to host cells (10), improved phagocytosis and intracellular killing of microbes (11), increased mucociliary clearance (12), interferon-like action (9,13) and enhancing effects on the production of cytokines (9). The latter two are especially essential for activation of innate defense mechanisms against infections (9,14).…”

EPs 7630, a Herbal Drug Preparation for Treating Acute Bronchitis in Children and Adults

“…The immune-modulatory activities are mainly mediated by the release of tumour-necrosis factor (TNF-) and nitric oxide (Kolodziej & Kiderlen, 2007;Thäle et al, 2011), stimulation of interferon- and an increase in natural killer cell activity (Koch et al, 2002). In cell cultures, EPs 7630 has been found to stimulate the ciliary beat frequency (Neugebauer et al, 2005), which may support a secromotoric effect during acute respiratory tract infections. Finally, EPs 7630 inhibits the lipopolysaccharide-induced sickness behaviour in mice in vivo (Nöldner & Schötz, 2007 …”

Antibacterial Spectrum of Umckaloabo (Pelargonium Sidoides) on Upper Airway Infectıon Agents

“…Thus, we considered that it would be useful for decreasing the treatment lenght and reducing the symptoms of the disease in EarNose-Throat departments frequent illnesses, tonsillitis and rhino-sinusitis. (18,19).…”