Multi-traveling salesman problem (MTSP) is an extension of traveling salesman problem, which is a famous NP hard problem, and can be used to solve many real world problems, such as railway transportation, routing and pipeline laying. In this paper, we analyze the general properties of MTSP, and find that the multiple depots and closed paths in the graph is a big issue for MTSP. Thus, a novel method is presented to solve it. We transform a complicated graph into a simplified one firstly, then an effective algorithm is proposed to solve the MTSP based on the simplified results. In addition, we also propose a method to optimize the general results by using 2-OPT. Simulation results show that our method can find the global solution for MTSP efficiently. The traveling salesman problem (TSP) is a typical combinatorial optimization problem. A generalization of the TSP is the multiple traveling salesmen problem (MTSP), which determines a set of routes enabling multiple salesmen to start at and return to depots. [17] used a competition-based neural network to solve a minmax MTSP. Thus far, GAs have been applied to a wide range of application areas, including solving the MTSP. Liaw et al. [18] proposed a hybrid genetic algorithm, which is based on tabu search, to solve the MTSP. Carter et al. [19] researched chromosome representation and related genetic operators to find an applicable method for solving the MTSP. Additionally, the ant system, which was proved by [7], is a perfectly acceptable meta-heuristic for a number of NP-hard problems. In [20], an ant system is applied to the MTSP.The MTSP seems to be more appropriate than the TSP for practical applications and can be used to simulate many everyday applications such as transportation logistics, job planning, vehicle scheduling, and so on. Some reported applications are presented in [10]. The main applications include print press scheduling [21], crew scheduling [22], school bus routing [23], mission planning [24], and the de-