A new approach to the rationale discovery of polymeric biomaterials

Kohn, Joachim; Welsh, William J.; Knight, Doyle

doi:10.1016/j.biomaterials.2007.06.022

Cited by 97 publications

(83 citation statements)

References 45 publications

(43 reference statements)

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“…A schematic representation of the various techniques and a summary of the information gained from each technique is summarised in Figure 5. The high throughput nature of this analysis is imperative when considering the combinatorial nature of the arrays being studied [3]. XPS allows the quantitative measurement of the elemental composition of the top 10 nm of the substrate surface.…”

Section: Polymer Characterisationmentioning

confidence: 99%

“…This has enabled revealing studies into the attachment of cells onto varied materials, and importantly, enabled material-cell interactions to be explored on materials that conventional studies would not have permitted due to time restrictions. In order to maximise the benefits that a high throughput platform provides, the biological response must also be assessed in a high throughput manner [3]. The use of fluorochromes has been widely used for the high throughput characterisation of DNA and protein microarrays [73] and can be used to detect quantitatively fluorescently labelled biomolecules on every polymer spot.…”

Section: Assessment Of Biological Response To Microarraysmentioning

confidence: 99%

“…To be useful, combinatorial methodologies require complementary high throughput characterisation approaches, to both define the chemical or material structure and 'screen' the performance in the desired application [3]. Thus, a large amount of effort has gone into bulk, surface and biological characterisation using approaches compatible with the high throughput philosophy [4].…”

Section: Introductionmentioning

confidence: 99%

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High throughput methods applied in biomaterial development and discovery

et al. 2010

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The high throughput discovery of new materials can be achieved by rapidly screening many different materials synthesised by a combinatorial approach to identify the optimal material that fulfils a particular biomedical application. Here we review the literature in this area and conclude that for polymers, this process is best achieved in a microarray format, which enable thousands of cell-material interactions to be monitored on a single chip. Polymer microarrays can be formed by printing pre-synthesised polymers or by printing monomers onto the chip where on-slide polymerisation is initiated.The surface properties of the material can be analysed and correlated to the biological performance using high throughput surface analysis, including time-of-flight secondary ion mass spectrometry (ToF-SIMS), Xray photoelectron spectroscopy (XPS) and water contact angle (WCA) measurements. This approach enables the surface properties responsible for the success of a material to be understood, which in turn provides the foundations of future material design. The high throughput discovery of materials using polymer microarrays has been explored for many cell-based applications including the isolation of specific 2 cells from heterogeneous populations, the attachment and differentiation of stem cells and the controlled transfection of cells.Further development of polymerisation techniques and high throughput biological assays amenable to the polymer microarray format will broaden the combinatorial space and biological phenomenon that polymer microarrays can explore, and increase their efficacy. This will, in turn, result in the discovery of optimised polymeric materials for many biomaterial applications.

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Section: Polymer Characterisationmentioning

confidence: 99%

Section: Assessment Of Biological Response To Microarraysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High throughput methods applied in biomaterial development and discovery

et al. 2010

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“…An emerging area in biopharmaceutical research involves design and synthesis of on-demand biomaterial research (Williams, 2009) as they not only are important as drug carriers but also act as more complex systems who have the ability to interact with a number of biological systems invivo (Kohn et al, 2007). Technology transfer for biomaterial synthesis has been challenging due to inability to reproduce conditions during scale up (Armstrong et al, 2006;Danson et al, 2004) but with the advent of Microwave assisted technology synthesis or organic biopolymers has been accomplished which is reviewed in this section by focusing on mainly on two applications Poly Lactic Acid (PLA) and Poly caprolactone (PCL).…”

Section: Polymer Synthesismentioning

confidence: 99%

Microwave Assisted Reactions in Organic Chemistry: A Review of Recent Advances

Jacob¹

2012

IJC

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Revolution in organic compound synthesis has been promoted by microwave assisted organic syntheses (MAOS) by which small molecules are built up into large polymers in a fraction of time. The need for different organic compound libraries for drug discovery, biomaterial development, automated library screening; proteomics etc has supported the emergence of innovative technologies for rapid combinatorial organic synthesis using MAOS synthesis. In previous reviews on this subject the focus of MAOS has been on the process of MAOS reactions rather than the importance given to the related applications. This review focuses on solid-phase synthesis, biopolymer synthesis, applications in proteomics, parallel processing in microwave reactors and automated library generation by means of sequential microwave irradiation methods. This article has discussed the different applications of Microwave assisted synthesis of organic polymeric compounds most thoroughly by focusing on aspects of speed, reproducibility and scalability. From this review it is clearly identified that independent on the type of organic material, data consistently points out to MW as a novel and powerful tool which has enable synthesis of a number of new compounds and presents the need for future research in this area.

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“…El diseño sistemático de biomateriales por medio de la química combinatoria se basa en la capacidad de sintetizar un gran número de derivados de una manera rápida, eficaz y reproducible [20,21]. Sin embargo, alcanzar dicho objetivo es complejo si se emplean vías sintéticas convencionales que demandan tiempos prolongados.…”

Section: Introductionunclassified

Aplicaciones de la tecnología de radiación de microondas en la síntesis de biomateriales

Sosnik¹,

Gotelli²

Biomateriais Aplicados Ao Desenvolvimento De Sistemas Terapêuticos Avançados

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A navegação consulta e descarregamento dos títulos inseridos nas Bibliotecas Digitais UC Digitalis, UC Pombalina e UC Impactum, pressupõem a aceitação plena e sem reservas dos Termos e Condições de Uso destas Bibliotecas Digitais, disponíveis em https://digitalis.uc.pt/pt-pt/termos.Conforme exposto nos referidos Termos e Condições de Uso, o descarregamento de títulos de acesso restrito requer uma licença válida de autorização devendo o utilizador aceder ao(s) documento(s) a partir de um endereço de IP da instituição detentora da supramencionada licença.Ao utilizador é apenas permitido o descarregamento para uso pessoal, pelo que o emprego do(s) título(s) descarregado(s) para outro fim, designadamente comercial, carece de autorização do respetivo autor ou editor da obra. Na medida em que todas as obras da UC Digitalis se encontram protegidas pelo Código do Direito de Autor e Direitos Conexos e demais legislação aplicável, toda a cópia, parcial ou total, deste documento, nos casos em que é legalmente admitida, deverá conter ou fazer-se acompanhar por este aviso.Aplicaciones de la tecnología de radiación de microondas en la síntesis de biomateriales. Autor(es):Sosnik, Alejandro; Gotelli, Gustavo Resumen:El escalado industrial de la producción de biomateriales poliméricos sintéticos y semi-sintéticos enfrenta desafíos relevantes como la limitada reproducibilidad y difícil estandarización de los procesos sintéticos. más recientemente, a su implementación en la síntesis de polímeros y materiales cerámicos para aplicaciones terapéuticas. El presente capí-tulo presenta el Estado-del-Arte de las aplicaciones más destacadas de esta tecnología en la síntesis de biomateriales poliméricos orgánicos e inorgánicos y discute el potencial de la misma para optimizar la transferencia a la clínica de nuevos biomateriales.Palabras clave: Síntesis de biomateriales poliméricos asistida por radiación de microondas; polimerización de apertura de anillo;polimerización de injerto molecular; hidrogeles; micropartículas y nanopartículas; materiales compuestos. Abstract:The industrial scale-up of the production of synthetic and semisynthetic polymeric biomaterials faces challenges due to the limited reproducibility and difficult standardization of the synthetic methods.The scale-up demands the adjustment of the process variables, a phase that is crucial and that is associated with the growth of the produc- This chapter presents a State-of-the-Art of the most relevant applications of microwave radiation for the synthesis of organic and inorganic polymeric biomaterials and discusses its potential to optimize the bench-to-bedside translation of new biomaterials.

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A new approach to the rationale discovery of polymeric biomaterials

Cited by 97 publications

References 45 publications

High throughput methods applied in biomaterial development and discovery

High throughput methods applied in biomaterial development and discovery

Microwave Assisted Reactions in Organic Chemistry: A Review of Recent Advances

Aplicaciones de la tecnología de radiación de microondas en la síntesis de biomateriales

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