A new ATL xenograft model and evaluation of pyrrolidine dithiocarbamate as a potential ATL therapeutic agent

Nakamura, Daisuke; Yoshimitsu, Makoto; Kuroki, Ayako; Hachiman, Miho; Kamada, Yuko; Ezinne, Chibueze; Arai, Akihiko; Inoue, H.; Hamada, Heiichirou; Hayashida, Maiko; Suzuki, Shinsuke; Fujino, Satoshi; Arima, Naosuke; Arima, M; Tabuchi, Tomohisa; Okada, Seiji; Arima, Naomichi

doi:10.1016/j.exphem.2015.06.303

Cited by 6 publications

(9 citation statements)

References 18 publications

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“…The potential for carcinogens to induce or accelerate tumour genesis has also been reported intensively [8,28,29]. Different strategies have been used to develop lymphoma models, such as humanized mice, xenografting, [3,4] or others [30,31] to mimic the effect of genetic and environmental factors on tumorigenesis. Here, we established a lymphoma model with 4 months of latent period of lymphoma instead of over 6 months.…”

Section: Discussionmentioning

confidence: 99%

“…In the early 1970s [2], a transplantable tumour was injected into CBA mice to model Gardner lymphosarcoma. The generation of adult T-cell leukaemia/lymphoma [3] and human acute B-lymphoblastic leukaemia [4] by xenotransplantation of primary peripheral blood mononuclear cells into combined immunodeficient mice were reported recently. In addition to the use of immunodeficient mice, irradiation or thymectomy have also been used to optimize models [5].…”

Section: Introductionmentioning

confidence: 99%

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WITHDRAWN: A uniform thymic malignant lymphoma model established with C57BL/6 p53 gene deficient mice

Fan¹,

Lyu²,

Liu³

et al. 2018

Oncotarget

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Lymphoma is the third most common cancer diagnosed in children and T cell lymphoma has the worst prognosis by clinical observation. So far, a lymphoma model with uniform penetrance has not been available. In this paper, we generated a p53 deficient mouse model by targeting embryo stem cells derived from the C57BL/6 mouse strain. Homozygous p53 deficient mice exhibited more accelerated rate of spontaneous tumorigenesis with a high spontaneous occurrence rate (93.3%) of malignant lymphoma. Because tumour models with a high phenotypic consistency are currently needed, we further generated the lymphoma model by single intraperitoneal injection of 37.5 or 75 mg/kg N-methyl-N-nitrosourea (MNU) to p53 deficient mice. Lymphoma and retinal degeneration occurred in 100% of p53 +/mice administrated higher concentration of MNU, which was much higher than previously reported models. The main anatomic sites of lymphoma were thymus, spleen, bone marrow, and lymph nodes. Both induced and spontaneous lymphomas in the thymus and spleen were stained positive for CD3 antigen. Furthermore, positive CD4 and/or positive CD8 cells were detected by flow cytometry, indicating a T-cell lineage of the lymphomas. The onset time of this uniform lymphoma model was from 13 to 17 weeks after the administration of MNU accompanied by the second time of weight loss. Based on our observations and previous data, we hypothesised that mice with the B6 background are prone to lymphomagenesis. This model could be used to study the mechanisms of lymphomagenesis, to select new drugs, and to improve the reproducibility of experimental results.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: A uniform thymic malignant lymphoma model established with C57BL/6 p53 gene deficient mice

Fan¹,

Lyu²,

Liu³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Another humanized ATL model was generated by Nakamura et al (2015) where PBMC from ATL patients were injected into NOD/SCID/Jak3-null mice (NOJ mice). In Brief, the model involved subcutaneous injection of the ATL S1T cell line into mice, followed by subcutaneous, intraperitoneal, or intravenous transplantation of primary ATL cells.…”

Section: Mouse Models Of Atlmentioning

confidence: 99%

“…In Brief, the model involved subcutaneous injection of the ATL S1T cell line into mice, followed by subcutaneous, intraperitoneal, or intravenous transplantation of primary ATL cells. ATL cells successfully infiltrated various organs and could transplant into secondary mice establishing NOJ mice as successful models for primary ATL xenotransplantation ( Nakamura et al, 2015 ).…”

Section: Mouse Models Of Atlmentioning

confidence: 99%

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Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia

et al. 2018

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Adult T cell Leukemia (ATL) is an aggressive lymphoproliferative malignancy secondary to infection by the human T-cell leukemia virus type I (HTLV-I) and is associated with a dismal prognosis. ATL leukemogenesis remains enigmatic. In the era of precision medicine in oncology, mouse models offer one of the most efficient in vivo tools for the understanding of the disease biology and developing novel targeted therapies. This review provides an up-to-date and comprehensive account of mouse models developed in the context of ATL and HTLV-I infection. Murine ATL models include transgenic animals for the viral proteins Tax and HBZ, knock-outs for key cellular regulators, xenografts and humanized immune-deficient mice. The first two groups provide a key understanding of the role of viral and host genes in the development of ATL, as well as their relationship with the immunopathogenic processes. The third group represents a valuable platform to test new targeted therapies against ATL.

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Advances in anticancer applications of platinum(II) complexes of dithiocarbamates

Ahmad

2024

Med Chem Res

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A new ATL xenograft model and evaluation of pyrrolidine dithiocarbamate as a potential ATL therapeutic agent

Cited by 6 publications

References 18 publications

WITHDRAWN: A uniform thymic malignant lymphoma model established with C57BL/6 p53 gene deficient mice

WITHDRAWN: A uniform thymic malignant lymphoma model established with C57BL/6 p53 gene deficient mice

Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia

Advances in anticancer applications of platinum(II) complexes of dithiocarbamates

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