A new benzil derivative from Derris scandens: Structure-insecticidal activity study

Sreelatha, T.; Hymavathi, A.; Rao, V. Rama Subba; Devanand, P.; Rani, Poonam; Rao, J. Madhusudana; Babu, K. Suresh

doi:10.1016/j.bmcl.2009.11.103

Cited by 29 publications

(14 citation statements)

References 21 publications

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“…The powder and hydroalcoholic extract of D. scandens stem were recorded in the National List of Essential Medicines of Thailand for the treatment of muscle pain, low back pain, and knee osteoarthritis [13]. The chemical constituents are benzil derivatives (derrisdione and scandione) [14,15], pterocarpens (flemichapparin B-C and maackian) [14], coumarins (scandenin, scandenin A-B, and robustic acid) [15][16][17], steroids (β-sitosterol and β-sitosterol glucopyranoside) [17], isoflavones (derrisisoflavones A-F, erysenegalensein E, genistein, lupalbigenin, lupinisol A, osajin, scandenone, scanderone, scandinone, 4′,5,7-trihydroxybiprenylisoflavone) [14][15][16]18], and isoflavone glycosides (derriscandenosied A-E and genistein 7-Ο-[α-rhamnopyranosyl-(1 → 6)]-βglucopyranoside) [19,20]. Several scientific studies indicated that scandenin, genistein, genistein 7-Ο-[α-rhamnopyranosyl-(1 → 6)]β-glucopyranoside, and lupalbigenin have an anti-inflammatory effect by inhibition of eicosanoid synthesis [20].…”

Section: Phosphodiesterase 5 Inhibitors From Derris Scandensmentioning

confidence: 99%

Phosphodiesterase 5 Inhibitors from Derris scandens

et al. 2018

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Phosphodiesterase 5 inhibitors have been used as a first-line medicine for the treatment of erectile dysfunction. In the search for new phosphodiesterase 5 inhibitors from natural sources, we found that the 95% ethanol extract of stem showed phosphodiesterase 5 inhibitory activity with an IC value of about 7 µg/mL. Seven isoflavones and a coumarin constituent isolated from this plant were investigated for phosphodiesterase 5 inhibitory activity. The results showed that osajin (8: ), 4',5,7-trihydroxybiprenylisoflavone (4: ), and derrisisoflavone A (2: ) had the ability to inhibit phosphodiesterase 5 with IC values of 4, 8, and 9 µM, respectively. These compounds exhibited selectivity on phosphodiesterase 5 over phosphodiesterase 1, however, the selectivity on phosphodiesterase 5 over phosphodiesterase 6 was low. In order to quantitatively determine these bioactive constituents in extract, LC-QTOF-MS method has been developed and validated. The limit of quantitation values in the range of 0.1 - 5 µg/mL were obtained. The assay showed satisfactory precision and accuracy. The results from our method showed that the 95% ethanol extract of stem was comprised of all eight compounds, with derrisisoflavone A (2: ) and lupalbigenin (3: ) presenting as the major constituents.

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Section: Phosphodiesterase 5 Inhibitors From Derris Scandensmentioning

confidence: 99%

Phosphodiesterase 5 Inhibitors from Derris scandens

et al. 2018

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“…Previous studies indicated the presence of coumarins, isoflavones, flavones, isoflavone glycosides and phenyl coumarins as chemical constituents from D. scandens (Sreelatha et al, 2010;Mahabusarakam et al, 2004). Now we are reporting two coumarins (1 and 2), four triterpenes (3-6), and two steroids (7 and 8) from the roots and stems extracts of D. scandens.…”

Section: Introductionmentioning

confidence: 79%

“…(family Leguminosae) is distributed in South East Asia and North Australia (Mahabusarakam et al, 2004). Its stem is widely used in traditional medicine as an anti-tussive, diuretic, expectorant and anti-dysentery agent and for treatment of muscle pains (Mahabusarakam et al, 2004), cough and diarrhea (Sreelatha et al, 2010). Insecticidal constituents, viz., rotenone and lonchocarpic acid, were reported also from the roots of D. scandens, and these compounds demonstrated insect anti-feedant activity (Rani et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical investigation and antimicrobial activity of Derris scandens

Hussain

Al‐Harrasi

Krohn

et al. 2015

Journal of King Saud University - Science

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Different fractions of root and stem of Derris scandens demonstrated good antibacterial (Escherichia coli, and Bacillus megaterium), antialgal (Chlorella fusca), and antifungal (Microbotryum violaceum) activities. Phytochemical investigation resulted in isolation of scandenin, scandenin A, betulinic acid, lupeol, b-amyran-3-one, b-amyrin, b-sitosterol and ß-sitosterol glucopyranoside. Study showed that scandenin has strong antibacterial activity against B. megaterium and good antifungal and antialgal properties. Scandenin A showed good antibacterial, antifungal and antialgal properties. ª 2015 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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“…In present study, some of the adultoids were unable to eclose properly from pupal exuviae or pupal exuviae remained attached to different parts of the body. This kind of detrimental effect on adult eclosion has also been observed as a consequence of treatment with plant extracts or their active ingredients (Lapcharoen et al, 2005;Nenaah, 2011;Soonwera & Phasomkusolsil, 2016;Sreelatha, Hymavathi, Rao, Devanand, & Rani, 2010). The plant extracts mimic the action of JHAs as exogenous administration of JHAs exert inhibitory effect on the neuropeptide, eclosion hormone, produced by the ventral tritocerebral neurosecretory cell which leads to inhibition of adult eclosion (Singh & Kumar, 2015a, 2015b.…”

Section: Discussionmentioning

confidence: 97%

A comparative bioefficacy of seed and root extracts of a medicinal plant, Withania somnifera when administered to prepupae of lepidopteran insects, Spodoptera litura (Lepidoptera: Noctuidae) and Pericallia ricini (Lepidoptera: Arctiidae)

Gaur

Kumar

2019

JoBAZ

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Background: The lepidopterans, Spodoptera litura and Pericallia ricini, are polyphagous pests of agricultural importance. The unscrupulous and non-judicious use of chemical pesticides for controlling the insect pests has resulted into severe environmental hazards, threatening non-target organisms and human health. Results: Administration of seed and root extracts of a medicinal plant, Ashwagandha (Withania somnifera) to prepupae of two economically important insect pests viz. S. litura and P. ricini resulted into disruption of molting and metamorphosis leading to a number of developmental aberrations such as prolongation of the life span of prepupae, postponement of pupal-adult ecdysis, ecdysial failure, reduced pupation and adult emergence, formation of larval-pupal and pupal-adult intermediates, abnormal pupae, and adultoids. Treatment with seed extracts of W. somnifera was more effective as it alone caused mortality in both the lepidopteran insects viz. S. litura and P. ricini, whereas no such effect was observed when treated with root extracts. P. ricini was more susceptible to W. somnifera as it resulted into formation of larval-pupal-adult chimeras in addition to effects described earlier, whereas this effect was not observed in the case of S. litura. Conclusion: These results are similar to these produced by the administration of JHAs and hence mimic their action by the way of interfering with the neuroendocrine system.

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A new benzil derivative from Derris scandens: Structure-insecticidal activity study

Cited by 29 publications

References 21 publications

Phosphodiesterase 5 Inhibitors from Derris scandens

Phosphodiesterase 5 Inhibitors from Derris scandens

Phytochemical investigation and antimicrobial activity of Derris scandens

A comparative bioefficacy of seed and root extracts of a medicinal plant, Withania somnifera when administered to prepupae of lepidopteran insects, Spodoptera litura (Lepidoptera: Noctuidae) and Pericallia ricini (Lepidoptera: Arctiidae)

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