A new biodegradable nano cellulose-based drug delivery system for pH-controlled delivery of curcumin

Anirudhan, T.S.; Manjusha, V.; Sekhar, V. Chithra

doi:10.1016/j.ijbiomac.2021.06.010

Cited by 49 publications

(14 citation statements)

References 28 publications

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“…In the biomedical field, owing to its biocompatibility, low cytotoxicity, and tunable surface features, it is becoming increasingly popular for the preparation of hydrogels, scaffolds for tissue engineering, and innovative drug delivery systems. Particularly, in the field of drug delivery it can be used as excipient (but also as starting matrix) to prepare NC-based oral, transdermal and local drug delivery systems, which are able to control drug release and improve both drug stability and therapeutic effects [ 33 , 34 , 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Valorization of Kiwi Peels: Fractionation, Bioactives Analyses and Hypotheses on Complete Peels Recycle

Cairone

Garzoli

Menghini³

et al. 2022

Foods

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Kiwi fruit samples (Actinidia deliciosa Planch, cv. Hayward) represent a suitable and good source for fibers obtainment as well as for polyphenolic and carotenoid extraction. With this aim, in this study they were submitted to a double phase extraction to separate insoluble fibers by an organic phase containing lipophilic substances and an hydroalcoholic phase containing polyphenols and soluble fibers. Insoluble fibers could be separated by filtration and sent to be micronized and reused. Hydroalcoholic fractions were then furtherly fractionated by solid-phase extraction. Data coming from the color CIEL*a*b* and the HPLC-DAD analyses of the extracts were compared and correlate with those coming from the SPME-GC/MS analysis of either the finely shredded peels or of the extracts. The obtained extracts were also submitted to anti-radical activity evaluation and anti-Candida activity. Results show that all of the obtained residues are value added products. Hypotheses were also made about the nature and the possible recycle of the obtained purified solid residue.

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Section: Resultsmentioning

confidence: 99%

Valorization of Kiwi Peels: Fractionation, Bioactives Analyses and Hypotheses on Complete Peels Recycle

Cairone

Garzoli

Menghini³

et al. 2022

Foods

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show abstract

“…Anomalous transport [165] Targeted drug delivery and controlled drug release rate are attractive methods to avoid the sudden drug release behaviors [169]. Anirudhan et al [170] prepared a nanocellulosebased carrier for effective delivery of curcumin. Under the pH of 8.0, the drug-loading ratio was as high as 89.2%.…”

Section: Non-fickian Diffusion [164]mentioning

confidence: 99%

Nanocellulose-Based Composite Materials Used in Drug Delivery Systems

et al. 2022

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Nanocellulose has lately emerged as one of the most promising “green” materials due to its unique properties. Nanocellulose can be mainly divided into three types, i.e., cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial cellulose (BC). With the rapid development of technology, nanocellulose has been designed into multidimensional structures, including 1D (nanofibers, microparticles), 2D (films), and 3D (hydrogels, aerogels) materials. Due to its adaptable surface chemistry, high surface area, biocompatibility, and biodegradability, nanocellulose-based composite materials can be further transformed as drug delivery carriers. Herein, nanocellulose-based composite material used for drug delivery was reviewed. The typical drug release behaviors and the drug release mechanisms of nanocellulose-based composite materials were further summarized, and the potential application of nanocellulose-based composite materials was prospected as well.

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“…Owing to promising developments in pharmaceutical sciences, the design and application of nanostructures have been one of the main topics of researches [1,2]. Generally, the aim of using nanomaterials in the medical elds has been to load and deliver signi cant quantities of therapeutic agents to the target cells and reduce the side effects [3][4][5]. For this purpose, various nanocarriers, including organic, inorganic, and hybrid types of nanoparticles, have been extensively developed [6-8].…”

Section: Introductionmentioning

confidence: 99%

Tuning the size and concentration of functional molecules coated onto mesoporous silica nanoparticles for efficient therapeutic protein delivery

Esmaeilnejad-Ahranjani

Maboudi²

2023

Materials Today Communications

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A new biodegradable nano cellulose-based drug delivery system for pH-controlled delivery of curcumin

Cited by 49 publications

References 28 publications

Valorization of Kiwi Peels: Fractionation, Bioactives Analyses and Hypotheses on Complete Peels Recycle

Valorization of Kiwi Peels: Fractionation, Bioactives Analyses and Hypotheses on Complete Peels Recycle

Nanocellulose-Based Composite Materials Used in Drug Delivery Systems

Tuning the size and concentration of functional molecules coated onto mesoporous silica nanoparticles for efficient therapeutic protein delivery

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