A new biphasic osteoinductive calcium composite material with a negative Zeta potential for bone augmentation

Smeets, Ralf; Kolk, Andreas; Gerressen, Marcus; Driemel, Oliver; Maciejewski, Oliver; Hermanns-Sachweh, Benita; Riediger, D; Stein, J.

doi:10.1186/1746-160x-5-13

Cited by 103 publications

(70 citation statements)

References 26 publications

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“…Therefore, the adhesion of osteoblasts to the implant is to a large extent determined by the electrical properties of the implant surface. Accordingly, many studies in the past indicated that increased negative surface potential of titanium implants promotes osteoblast adhesion and consequently, to new bone formation [29,31,32]. It it shown in this work that depletion and water ordering near the charged surface of a metal implant locally decrease the relative permittivity.…”

Section: Langevin-bikerman Stern (Lbs) Model For Finite-sized Ionsmentioning

confidence: 65%

“…It it shown in this work that depletion and water ordering near the charged surface of a metal implant locally decrease the relative permittivity. The electric field strength and the magnitude of the negative electric potential in the close vicinity of the implant surface, due to this effect, are substantially increased which is of a crucial importance for the improved adhesion of cells to the metal surface [28,29,31,32]. Accordingly, it has been shown recently that the topography of a nanostructured implant surface is a decisive factor for surface cell adhesion and growth [33][34][35].…”

Section: Langevin-bikerman Stern (Lbs) Model For Finite-sized Ionsmentioning

confidence: 99%

“…The mechanism of the initial adhesion of osteoblastic cells to the implant surface is based on a protein and cation mediated attractive interaction between two negatively charged surfaces [25][26][27], i.e. the negatively charged implant surface and the negatively charged osteoblasts [28][29][30]. Therefore, the adhesion of osteoblasts to the implant is to a large extent determined by the electrical properties of the implant surface.…”

Section: Langevin-bikerman Stern (Lbs) Model For Finite-sized Ionsmentioning

confidence: 99%

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Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime

Gongadze

Rienen

Iglič

2011

Cellular and Molecular Biology Letters

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Abstract:The interaction between a charged metal implant surface and a surrounding body fluid (electrolyte solution) leads to ion redistribution and thus to formation of an electrical double layer (EDL). The physical properties of the EDL contribute essentially to the formation of the complex implantbiosystem interface. Study of the EDL began in 1879 by Hermann von Helmholtz and still today remains a scientific challenge. The present mini review is focused on introducing the generalized Stern theory of an EDL, which takes into account the orientational ordering of water molecules. To ascertain the plausibility of the generalized Stern models described, we follow the classical model of Stern and introduce two Langevin models for spatial variation of the relative permittivity for point-like and finite sized ions. We attempt to uncover the subtle interplay between water ordering and finite sized ions and their impact on the electric potential near the charged implant surface. Two complementary effects appear to account for the spatial dependency of the relative permittivity near the charged implant surface -the dipole moment vectors of water molecules are predominantly oriented towards the surface and water molecules are depleted due to the accumulation of counterions. At the end the expressions for relative permittivity in both Langevin models were generalized by also taking into account the cavity and reaction field.

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Section: Langevin-bikerman Stern (Lbs) Model For Finite-sized Ionsmentioning

confidence: 65%

Section: Langevin-bikerman Stern (Lbs) Model For Finite-sized Ionsmentioning

confidence: 99%

Section: Langevin-bikerman Stern (Lbs) Model For Finite-sized Ionsmentioning

confidence: 99%

See 1 more Smart Citation

Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime

Gongadze

Rienen

Iglič

2011

Cellular and Molecular Biology Letters

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“…Firstly, the osteoblast cell membrane makes a nonspecific contact due to electrostatic forces, 15 followed by a second step where specific binding involving integrin assembly into focal contacts takes place. 16,23,24 Since osteoblasts are negatively charged, 25 they are electrostatically repelled by the negatively charged titanium surface as long as some other attractive forces are not present in the system. Recently, a possible mechanism of osteoblast adhesion to the implant surface was proposed on the assumption that positively charged proteins 25,26 or proteins with positively charged tips, ie, a quadrupolar internal charge distribution 15 attached to the negatively charged implant surface, serve as a substrate for the subsequent attachment of negatively charged osteoblasts.…”

Section: Adhesion Of Proteins To a Titanium Surfacementioning

confidence: 99%

Adhesion of osteoblasts to a nanorough titanium implant surface

Gongadze¹,

Kabaso²,

Bauer³

et al. 2011

IJN

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This work considers the adhesion of cells to a nanorough titanium implant surface with sharp edges. The basic assumption was that the attraction between the negatively charged titanium surface and a negatively charged osteoblast is mediated by charged proteins with a distinctive quadrupolar internal charge distribution. Similarly, cation-mediated attraction between fibronectin molecules and the titanium surface is expected to be more efficient for a high surface charge density, resulting in facilitated integrin mediated osteoblast adhesion. We suggest that osteoblasts are most strongly bound along the sharp convex edges or spikes of nanorough titanium surfaces where the magnitude of the negative surface charge density is the highest. It is therefore plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblasts.

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“…At pH 7.4, ALN results in positive zeta potentials, while RIS results in negative ones as a function of concentration, most likely due to the differing nitrogen charges/species among the two bisphosphonates. (1) Cells may sense and react to this potential, (46)(47)(48)(49)(50)(51)(52)(53) thus it is plausible that the different affinities and zeta-potentials influence osteoblastic function differently, quantitatively and/or qualitatively.…”

Section: Discussionmentioning

confidence: 99%

Effects of alendronate and risedronate on bone material properties in actively forming trabecular bone surfaces

Hofstetter

Gamsjaeger

Phipps³

et al. 2012

Journal of Bone and Mineral Research

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We used Raman and Fourier transform infrared microspectroscopy (FTIRM) analysis to examine the intrinsic bone material properties at actively bone-forming trabecular surfaces in iliac crest biopsies from women with postmenopausal osteoporosis (PMO) who were treated with either alendronate (ALN) or risedronate (RIS). At eight study sites, women were identified who had postmenopausal osteoporosis (PMO), were at least 5 years postmenopause, and had been on long-term therapy (either 3-5 years or >5 years) with daily or weekly ALN or RIS. Following standard tetracycline labeling, biopsies were collected from 102 women (33 treated with ALN for 3-5 years , 35 with ALN for >5 years , 26 with RIS for 3-5 years , and 8 with RIS for >5 years ) and were analyzed at anatomical areas of similar tissue age in bone-forming areas (within the fluorescent double labels). The following outcomes were monitored and reported: mineral to matrix ratio (corresponding to ash weight), relative proteoglycan content (regulating mineralization commencement), mineral maturity (indicative of the mineral crystallite chemistry and stoichiometry, and having a direct bearing on crystallite shape and size), and the ratio of two of the major enzymatic collagen cross-links (pyridinoline/divalent). In RIS-5 there was a significant decrease in the relative proteoglycan content (À5.83% compared to ALN-5), while in both RIS-3 and RIS-5 there was significantly lower mineral maturity/ crystallinity (À6.78% and À13.68% versus ALN-3 and ALN-5, respectively), and pyridinoline/divalent collagen cross-link ratio (À23.09% and À41.85% versus ALN-3 and ALN-5, respectively). The results of the present study indicate that ALN and RIS exert differential effects on the intrinsic bone material properties at actively bone-forming trabecular surfaces. ß

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A new biphasic osteoinductive calcium composite material with a negative Zeta potential for bone augmentation

Cited by 103 publications

References 26 publications

Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime

Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime

Adhesion of osteoblasts to a nanorough titanium implant surface

Effects of alendronate and risedronate on bone material properties in actively forming trabecular bone surfaces

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