A New Blood-Group Antibody, Anti-Jkb

Abstract

The Editors do not hold themselves responsible for opinions expressed by their correspondents. No notice is taken of anonymous communicationsA New Blood-Group Antibody, Anti-Jkb THE human blood-group system called Kidd was discovered in 1951 by Allen, Diamond and Niedziela. 1 , who found an antibody, anti-Jkn•, which distinguished two phenotypes, Jk(a +) and Jk(a-).Family investigations• showed that the antigen Jk'' is inherited and that the gene Jka is capable of expressing itself in single and in double dose ; the existence of an allelomorphic gene Jkb was assumed. In tests on 390 rmrelated persons•, the phenotype frequencies were Jk(a+) 76•92 per cent and Jk(a-) 23•08 per cent, from which the following gene and genotype frequencies were calculated : Genes Jk" 0 •5196 JJ.,.b 0•4804 Genotypes Jk"Jk" 0 •2700 Jk•Jk,b 0•4992 J~Jkb 0•2308

Genomic characterization of the Kidd blood group gene:different molecular basis of the Jk(a–b–) phenotypein Polynesians and Finns

“…The Kidd (JK) blood group system was discovered by Allen et al 1 in 1951 because of a red cell anti‐ body (anti‐Jk a ) in the serum of Mrs. Kidd, whose infant suffered from hemolytic disease of the newborn. Antibodies defining the antithetical antigen (Jk b ) were found by Plaut et al 2 2 years later in the serum of a woman experiencing a transfusion reaction. The null phenotype, Jk(a–b–), was noted in a Philippine woman during investigation of her serum, which contained alloantibodies reacting with all available donor cells 3 .…”

A Fatal Case of Severe Hemolytic Disease of Newborn Associated with Anti-Jkb

“…The antithetical anti-Jk b was reported by Plaut et al (5) in 1953. Anti Jk b can cause hemolytic disease that is usually a mild and has a benign prognosis (6).…”

“…Anti-Jk b was first described by Plaut et al in 1953 (5). Most of the reports on anti-Jk b have stated that this condition followed after repeated blood transfusions (9, 10).…”

Jk3 alloantibodies during pregnancy—blood bank management and hemolytic disease of the fetus and newborn risk

“…1 The identification of an antibody directed against Jk b , the antithetical antigen of Jk a , was reported 2 years later. 2 Three Kidd phenotypes, Jk(a 1 b2), Jk(a2b1), and Jk(a 1 b1), are widely distributed among most ethnic groups. The Kidd-null phenotype, Jk(a2b2), was first described in 1959 in the context of a case of jaundice following blood transfusion in a Filipino woman.…”

“…The Jk a antigen was determined to be the target of this antibody, and the blood group system to which it belongs was named after the deceased child, John Kidd . The identification of an antibody directed against Jk b , the antithetical antigen of Jk a , was reported 2 years later …”