Flexure-based compliant mechanisms are increasingly promising in precision engineering, robotics, and other applications, thanks to the excellent advantages of no friction, no backlash, no wear, and minimal assembly. However, their design and analysis are still challenging due to the coupling of kinematic-mechanical behaviors with large nonlinear deflections in comparison to their rigid-body counterparts. Optimal design is an important aspect in the field of compliant mechanisms and has attracted much attention during the last decades. Especially, when considering a multiobjective optimization design for compliant mechanisms, the problem is becoming more complicated. Thus, this article presents a new efficient hybrid computational method to resolve multiobjective optimization design of compliant mechanisms. A Scott Russell compliant mechanism is employed as the design example and to show the advantages of the proposed optimizing method. The proposed method is developed by hybridizing the desirability function approach, fuzzy logic system, adaptive neuro-fuzzy inference system (ANFIS), and lightning attachment procedure optimization (LAPO). First of all, a 3D finite element model is created and central composite design is employed to build a numerical matrix. First, design variables are refined by using analysis of variance and Taguchi approach in terms of considerably eliminating space of design variables. Subsequently, desirability values of two objective functions are determined and transferred into the fuzzy logic system. The output of the fuzzy logic system is considered as a single combined objective function. Next, modeling for fuzzy output is established via developing the ANFIS model. At last, the LAPO algorithm is adopted for solving the multiobjective optimization problem for the mechanism. Three numerical examples are investigated to validate the feasibility and the effectiveness of performance efficiency of the proposed methodology. The results find that the proposed methodology is more efficient than traditional Taguchi-based fuzzy logic. Besides, the performance efficiency of the proposed approach outperforms the Jaya algorithm and TLBO algorithm through the Wilcoxon signed rank test and Friedman test. The results of this article give a useful approach for complex optimization problems.