A new C ₁₉ -diterpenoid alkaloid in Aconitum georgei Comber

Abstract

Nine diterpenoid alkaloids were isolated from Aconitum georgei Comber belonging to the genus Aconitum in Ranunculaceae family.Their structures were determinated by using HR-ESI-MS and 1D/2D NMR spectra as geordine (1), yunaconitine (2), chasmanine (3), crassicauline A (4), forestine (5), pseudaconine (6), 14-acetylalatisamine (7), austroconitine B (8), and talatisamine (9). Among them, compound 1 is a previously undescribed aconitine-type C19-diterpenoid alkaloid, and compounds 3, and 5-9 have not previously been isolated from this species. The results of in vitro experiments indicated that new compound 1 possesses mild anti-inflammatory activity, which inhibited the production of NO in LPS-activated RAW 264.7 cells with an inhibition ratio of 29.75% at 50 μM.

A New Highly Oxygenated Polyketide Derivative from Trichoderma sp. and Its Antifungal Activity

“…[18] Aconitum carmichaelii Debeaux is a large genus of the Ranunculaceae family, consisting of about 400 species distributed in the northern hemisphere's temperate regions and 211 species (166 endemic) in China. [19] In addition to two species that are officially listed in the Chinese Pharmacopoeia (A. carmichaelii Debeaux and A. kusnezoffii Reichb), at least 76 species of Aconitum are used medicinally by indigenous communities. [20] Their roots were used for the treatment of acute myocardial infarction, heart failure, rheumatoid arthritis, and analgesics.…”

Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities

“…Stylosine A (157) showed significant inhibitory activity against LPS-induced production of inflammatory cytokines (IL-1β, COX-2, and TNF-α) in RAW264.7 cells at a dose of 0.1 µg/mL without cytotoxicity [74]. Geordine (103) exhibited specific anti-inflammatory activity and inhibited LPS-induced NO production in RAW264.7 cells at 50 µM, with an inhibition rate of 29.75% [61]. Ajacisines F-H (121, 123, and 214) showed strong anti-inflammatory activity by inhibiting LPS-induced NO production in BV-2 cells, with inhibition rates of 80% at 50 µM and no cytotoxicity [70].…”