A New C₁₉-Diterpenoid Alkaloid fromAconitum vilmorinianum

Abstract

A new C 19 -diterpenoid alkaloid, 1-epi-16β-hydroxycardiopetaline, together with 19 known diterpenoid alkaloids, was isolated from the roots of Aconitum vilmorinianum Kom. The structure of the new alkaloid was established on the basis of spectral data (HR-MS, X-ray crystallographic analysis, 1D-and 2D-NMR).

Diterpenoid alkaloids from Aconitum vilmorinianum

“…Aconitum vilmorinianum Kom., a perennial herb widely distributed in Yunnan, Sichuan and Guizhou Province of China, has long been utilized to treat rheumatism and pains by natives. About thirty alkaloids, mainly aconitine-type C 19 -diterpenoid alkaloids, have been isolated from A. vilmorinianum (Xiao et al, 2006;Tang et al, 2014). During a search for bioactive chemicals from natural sources, A. vilmorinianum was phytochemically investigated to afford a novel skeleton 7, 17-seco-type C 19 -diterpenoid alkaloid vilmorine A (1), which has a unique rearranged six-membered B ring formed by the C (8) -C (9) linkage along with a rare b-orientation of OCH 3 -1, two unusual ones vilmorines B (2) and C (3) possessing a three-membered ring formed by the C (8) -C (9) -C (10) linkage, and a new lappaconitine-type C 18 -diterpenoid alkaloid vilmorine D (Fig.…”

Four New Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii

“…Known compounds were identified as songorine (5), [19] songoramine (6), [20] sachaconitine (7), [21] talatisamine (8), [22] chasmanine (9), [23] 14-acetyltalatisamine (10), [24] 3-deoxyhokbusine A (11), [25] 14-benzoylaconine (12), [26] hypaconitine (13), mesaconitine (14), [4] aconitine (15), [27] and beiwutine (16) [28] by comparison of their spectroscopic data with those reported in the literature.…”

Unusual C19-diterpenoid alkaloids from Aconitum vilmorinianum var. patentipilum

“…1). In addition, seven known alkaloids, vilmorine D (4) (Yin et al, 2015), talatizidine (5), isotalatizidine (6) (Pelletier and Djarmati, 1976), vilmorrianine B (7) (Pelletier et al, 1977), vilmorrianine D (8), talatizamine (9) (Tang et al, 2014), 8-deacetyl-yunaconitine (10) (Liang and Chen, 1989) have also been isolated from this species. Compounds 4-8, and 10 were isolated from this species for the first time.…”