A new caffeic acid ester and a new ceramide from the roots of Eriosema glomeratum

Tabakam, Gaétan Tchangou; Kodama, Tohru; Donfack, Arno Rusel Nanfack; Nguekeu, Yves Martial Mba; Nomin-Erdene, Battsengel; Htoo, Zin Paing; Minh, Kiep; Ngouela, Silvère; Téné, Mathieu; Morita, Hiroyuki; Awouafack, Maurice D.

doi:10.1016/j.phytol.2021.07.019

Cited by 11 publications

(1 citation statement)

References 37 publications

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“…Caffeic acid (3,4-dihydroxycinnamic acid) has been known as an important source of natural antioxidants in different agricultural products [ 284 , 285 ]. It has immense use in cancer treatment [ 286 , 287 ], and it could be known as an important natural antioxidant [ 288 ]. Caffeic acid can induce apoptosis in cancer cells through increasing ROS levels and impairing mitochondrial function, and it also benefits from reducing aggressive behavior of tumors via suppressing metastasis [ 289 ].…”

Section: Hydroxycinnamic Acids ( P -Coumaric Acid ...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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Section: Hydroxycinnamic Acids ( P -Coumaric Acid ...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes

Matchide,

Hnin,

Nguekeu

et al. 2023

Chemistry & Biodiversity

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A new fructofuranoside glycerol, dryoptkirbioside (1), along with fourteen known compounds (2‐15), was isolated from the MeOH extract of Dryopteris kirbi rhizomes by silica gel column chromatography, Sephadex LH‐20 column chromatography, and semipreparative HPLC. The structure of the new compound was determined by analyses of its spectroscopic data including nuclear magnetic resonance (NMR), and high‐resolution electrospray ionisation mass spectrometry (HRESI‐MS) and chemical conversions. The n‐hexane‐soluble portion and the EAFA fraction showed strong activities against lung (A549), breast (MCF‐7), and cervical (HeLa) human cancer cell lines (IC50 values ranging from 4.0 to 8.8 µg/mL). Aspidinol P (5) and aspidinol B (6) exhibited moderate to low cytotoxicity on the three cell lines (IC50 values ranging from 20.4 to 58.7 µM). The MeOH extract and n‐hexane‐soluble portion had excellent activities against Staphylococcus aureus and Bacillus subtilis (MICs 11.7 and 23.4 µg/mL), whereas the EtOAc‐ and n‐BuOH‐soluble portions were significantly active on S. aureus (MICs 46.9 and 93.8 µg/mL). The main fractions EAFB, EAFC and nBFB displayed excellent activity against S. aureus (MICs 11.7 and 23.4 µg/mL). Aspidinol B (6) had significant activity, while aspidinol P (5) was moderately active against S. aureus and B. subtilis (MICs 42.0 and 89.5 µM).

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A new ceramide and other constituents from the fruits of Ficus lutea Vahl (Moraceae) and their chemotaxonomic significance

Fozeng

Donfack

Tchuenmogne

et al. 2023

Biochemical Systematics and Ecology

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A new caffeic acid ester and a new ceramide from the roots of Eriosema glomeratum

Cited by 11 publications

References 37 publications

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes

A new ceramide and other constituents from the fruits of Ficus lutea Vahl (Moraceae) and their chemotaxonomic significance

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