A New Calibration Circuit Design to Reduce Drift Effect of RuO2 Urea Biosensors

Abstract

The goal of this study was to reduce the drift effect of RuO2 urea biosensors. A new calibration circuit (NCC) based on the voltage regulation technique with the advantage of having a simple structure was presented. To keep its simplicity, the proposed NCC was composed of a non-inverting amplifier and a voltage calibrating circuit. A ruthenium oxide (RuO2) urea biosensor was fabricated to test the calibrating characteristics of the drift rate of the proposed NCC. The experiment performed in this study was divided into two main stages. For the first stage, a sound RuO2 urea biosensor testing environment was set-up. The RuO2 urea sensing film was immersed in the urea solution for 12 h and the response voltage was measured using the voltage-time (V–T) measurement system and the proposed NCC. The results of the first stage showed that the RuO2 urea biosensor has an average sensitivity of 1.860 mV/(mg/dL) and has a linearity of 0.999 which means that the RuO2 urea biosensor had been well fabricated. The second stage of the experiment verified the proposed NCC’s functions, and the results indicated that the proposed NCC reduced the drift rate of RuO2 urea biosensor to 0.02 mV/hr (98.77% reduction).

An EGFET Based Common Source Amplifier as a Low-Frequency Instrumentation Amplifier for Sensitivity Measurement on RuO2 Lactic Acid Biosensor

“…To compare, the sensing characteristics of the array LA biosensor were measured through the traditional V-T measurement system as shown in Figure 5. The measurement system was composed of a data acquisition card (DAQ), an instrumental amplifier, and LabVIEW software [43], [44]. The input voltage of the sensing windows and the reference electrode was transmitted to the IA (LT1167), and the output voltage was transmitted to the DAQ to convert the analog signal into a digital signal.…”

Recent advancements in urea biosensors for biomedical applications

“…This biosensor introduced a new calibration circuit aimed at reducing the urea biosensor's drift rate influence. The findings revealed a mean specificity of 01.860 mV/(mg/dL) and a repetitiveness of 00.999 for the RuO 2 based urea biosensor [ 99 ].…”

Improving the Drift Effect and Hysteresis Effect of Urea Biosensor Based on Graphene Oxide/Nickel Oxide Sensing Film Modified Either by Au Nanoparticles or γ-Fe₂O₃ Nanoparticles Using Back-End Calibration Circuit

“…Therefore, the gate-source voltage (Vgs) of Mp increases and generate more current to charge the output capacitor so that the output voltage of Vc can maintain at a certain level. On the contrary, by changing the voltage and current, the output voltage is maintained at the certain level in a short time [20].…”

“…The drift behavior is due to the increase in the thickness of the hydrated layer during the long-term measurement, which leads to an increase in the drift rate [19]. In this article, we further apply back-end calibration circuit, which is developed by Kuo et al [20] to reduce the drift effect and hysteresis effect of the two types of the urea biosensors.…”