A new case of occupational asthma from reactive dyes with severe anaphylactic response to the specific challenge

Romano, Canzio; Sulotto, F; Pavan, I; Chiesa, A.; Scansetti, G

doi:10.1002/ajim.4700210210

Cited by 28 publications

(13 citation statements)

References 8 publications

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“…Cutaneous and anaphylactic reactions have occasionally been reported during SICs [136][137][138][139][140]. Skin contact with occupational agents should be reduced as much as possible during SIC by using protective clothes or closed-circuit delivery systems.…”

Section: Cutaneous and Anaphylactic Reactionsmentioning

confidence: 99%

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

et al. 2014

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This consensus statement provides practical recommendations for specific inhalation challenge (SIC) in the diagnosis of occupational asthma. They are derived from a systematic literature search, a census of active European centres, a Delphi conference and expert consensus. This article details each step of a SIC, including safety requirements, techniques for delivering agents, and methods for assessing and interpreting bronchial responses. The limitations of the procedure are also discussed.Testing should only be carried out in hospitals where physicians and healthcare professionals have appropriate expertise. Tests should always include a control challenge, a gradual increase of exposure to the suspected agent, and close monitoring of the patient during the challenge and for at least 6 h afterwards. In expert centres, excessive reactions provoked by SIC are rare.A positive response is defined by a fall in forced expiratory volume in 1 s o15% from baseline. Equivocal reactions can sometimes be clarified by finding changes in nonspecific bronchial responsiveness, sputum eosinophils or exhaled nitric oxide. The sensitivity and specificity of SIC are high but not easily quantified, as the method is usually used as the reference standard for the diagnosis of occupational asthma. @ERSpublications ERS Task Force: a statement on specific inhalation challenges in the diagnosis of occupational asthma

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Section: Cutaneous and Anaphylactic Reactionsmentioning

confidence: 99%

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

et al. 2014

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“…For those subjects who demonstrate LAR or DAR, initiating or increasing inhaled steroids for a few days is indicated. Cutaneous and anaphylactoid reactions have occasionally been described [65,66].…”

Section: Pitfallsmentioning

confidence: 99%

Inhalation challenges with agents causing occupational asthma

Vandenplas¹,

Jl²

1997

Eur Respir J

124

103

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Occupational asthma (OA) is steadily emerging as the principal cause of respiratory disease due to the workplace environment. One of the key means to ascertain diagnosis of OA is specific inhalation challenge (SIC) with occupational agents. This review: 1) describes the methodology of SIC, with a special emphasis on procedures aimed at increasing the safety and validity of these tests; and 2) outlines the roles of SIC in the diagnosis of OA in clinical and medicolegal assessment, epidemiological studies, surveillance programmes and the investigation of the pathophysiological mechanisms of asthma and OA. We discuss areas of future development, including the development of apparatus which allows exposure of subjects to low and stable concentrations of the occupational agent and the assessment of preventive procedures.

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“…There are many RDs with different reactive functional groups to which carrier proteins bind to induce immune responses 2,11,13. The vinyl sulfone RDs are major causes of OA and have one or two vinyl sulfone reactive groups 10,14,15. Black GR, the most frequent sensitizer, has two vinyl sulfone reactive groups,9 while Red-K has one.…”

Section: Discussionmentioning

confidence: 99%

Occupational Asthma Induced by the Reactive Dye Synozol Red-K 3BS

Jin

Kim

et al. 2011

Allergy Asthma Immunol Res

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Various reactive dyes can elicit occupational asthma in exposed textile industry workers. To date, there has been no report of occupational asthma caused by the red dye Synozol Red-K 3BS (Red-K). Here, we report a 38-year-old male textile worker with occupational asthma and rhinitis induced by inhalation of Red-K. He showed positive responses to Red-K extract on skin-prick testing and serum specific IgE antibodies to Red-K-human serum albumin conjugate were detected using an enzyme-linked immunosorbent assay. A bronchoprovocation test with Red-K extract resulted in significant bronchoconstriction. These findings suggest that the inhalation of the reactive dye Red-K can induce IgE-mediated occupational asthma and rhinitis in exposed workers.

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A new case of occupational asthma from reactive dyes with severe anaphylactic response to the specific challenge

Cited by 28 publications

References 8 publications

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

Inhalation challenges with agents causing occupational asthma

Occupational Asthma Induced by the Reactive Dye Synozol Red-K 3BS

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