A New Chalcone and Antioxidant Constituents of Glycyrrhiza glabra

Chen, Jih Jung; Cheng, Ming‐Jen; Shu, Chih‐Wen; Sung, Ping Jyun; Lim, Yun Ping; Chen, Lin; Wang, Sin Ling; Chen, Li Chai

doi:10.1007/s10600-017-2077-1

Cited by 14 publications

(11 citation statements)

References 7 publications

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“…The chemical structure of these compounds is based on the presence of two aromatic rings—A and B—connected with the three carbon chain containing an α,β-unsaturated bond and a carbonyl group [1]. Chalcones maintain an unflagging interest among scientists due to their broad spectrum of biological activities, including antibacterial [2], antifungal [3], anticancer [4,5,6], antioxidant [7] and anti-inflammatory properties [8]. Their biocapability is correlated with the different electron-donor and electron-acceptor groups attached to the aromatic rings [9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel Aminochalcones as Potential Anticancer and Antimicrobial Agents

et al. 2019

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A series of 18 aminochalcone derivatives were obtained in yields of 21.5–88.6% by applying the classical Claisen-Schmidt reaction. Compounds 4–9, 14 and 16–18 with 4-ethyl, 4-carboxy-, 4-benzyloxy- and 4-benzyloxy-3-methoxy groups were novel, not previously described in the scientific literature. To determine the biological properties of the synthesized compounds, anticancer and antimicrobial activity assays were performed. Antiproliferative potential was evaluated on four different human colon cancer cell lines—HT-29, LS180, LoVo and LoVo/DX —using the SRB assay and compared with green monkey kidney fibroblasts COS7. Anticancer activity was described as the IC50 value. The best results were observed for 2′-aminochalcone (1), 3′-aminochalcone (2) and 4′-aminochalcone (3) (IC50 = 1.43–1.98 µg·mL−1) against the HT-29 cell line and for amino-nitrochalcones 10–12 (IC50 = 2.77–3.42 µg·mL−1) against the LoVo and LoVo/DX cell lines. Moreover, the antimicrobial activity of all derivatives was evaluated on two strains of bacteria: Escherichia coli ATCC10536 and Staphylococcus aureus DSM799, the yeast strain Candida albicans DSM1386 and three strains of fungi: Alternaria alternata CBS1526, Fusarium linii KB-F1 and Aspergillus niger DSM1957. In the case of E. coli ATCC10536 almost all derivatives hindered the bacterial growth (∆OD = 0). Furthermore, the best results were observed in the presence of 4′-aminochalcone (3), that completely limited the growth of all tested strains at the concentration range of 0.25–0.5 mg·mL−1. The strongest bacteriostatic activity was exhibited by novel 3′-amino-4-benzyloxychalcone (14), that prevented the growth of E. coli ATCC10536 with MIC = 0.0625 mg·mL−1.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel Aminochalcones as Potential Anticancer and Antimicrobial Agents

et al. 2019

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“…Materials All 4 0 -methylchalcone derivatives (1)(2)(3)(4)(5)(6)(7)(8) were prepared with the procedure described by Amir et al with yield 60-94%. 20 Biotransformations were performed using two strains of bacteria -Gordonia sp.…”

Section: Methodsmentioning

confidence: 99%

“…In the case of S. aureus DSM799 growth, dihydrochalcones with alkyl group attached to the C-4 (1a, 2a, 5a) had inhibitory effect 3 times stronger than corresponding chalcones (1,2,5). Furthermore, biotransformation products with O-alkyl chains at the C-4 position (3a, 6a) exhibited 2 times stronger activity in comparison to their chalcones (3,6). Only, 2,4-dimethoxy-4 0 -methyl-a,b-dihydrochalcone (4a) showed inhibitory effect similar to its chalcone (4).…”

Section: Spectral Data Of Biotransformation Productsmentioning

confidence: 99%

Microbial transformations of 4′-methylchalcones as an efficient method of obtaining novel alcohol and dihydrochalcone derivatives with antimicrobial activity

et al. 2018

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“…Quercetin was control in this test. The percentage of DPPH radical scavenging activity was calculated in the following way [24,25]: Equation 1.…”

Section: Plant Materialmentioning

confidence: 99%

Evaluation of possible antioxidant activities of barberry solid formulation, a selected formulation from Traditional Persian Medicine (TPM) via various procedures

2019

Biointerface Res Appl Chem

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The purpose of this study is to reformulate a solid traditional Ghors-e- zereshk (barberry traditional tablet) from Traditional Persian Medicine (TPM) and to assess the antioxidant effect and determining the total phenol and flavonoids contents of water and hydroalcoholic extract of mentioed formulation. The antioxidant effects of water and hydroalcoholic extracts of barberry solid formulation were measured by three methods: DPPH radical scavenging, nitric oxide free radical scavenging and Ferric Reducing Antioxidant Power Assay (FRAP) reducing method. The total phenol and flavonoid content were measured by Folin-Ciocalteu and aluminum chloride colorimetric methods. For standardization ashes’ test also used. The hydro-alcoholic extract has more phenolic compounds (31.46±.13 mg GAE∕g of dry matter) than the water extract and the water extract has more flavonoid compounds (6.38±. 25 mg Quercetin ∕g of dry matter) than the hydro-alcoholic extract. The result of DPPH radical scavenging shows that the hydro-alcoholic extract has more effect than the water extract. FRAP value indicates that the hydro-alcoholic extract has more reductive activity than the water extract. The study of NO radical scavenging represents water extract 74.61±2.95 %, hydro-alcoholic extract 61.72±1.79 % thus, water and hydro-alcoholic extracts are powerful antioxidants and have hepatoprotective effects. Other relative biological effects, for example, the protective effects through oxidative stress can also be considered.

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A New Chalcone and Antioxidant Constituents of Glycyrrhiza glabra

Cited by 14 publications

References 7 publications

Synthesis and Biological Evaluation of Novel Aminochalcones as Potential Anticancer and Antimicrobial Agents

Synthesis and Biological Evaluation of Novel Aminochalcones as Potential Anticancer and Antimicrobial Agents

Microbial transformations of 4′-methylchalcones as an efficient method of obtaining novel alcohol and dihydrochalcone derivatives with antimicrobial activity

Evaluation of possible antioxidant activities of barberry solid formulation, a selected formulation from Traditional Persian Medicine (TPM) via various procedures

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