A new childhood pathway for transmission of an increased likelihood of smoking?

Anthonisen, Nicholas A.

doi:10.1503/cmaj.050704

Cited by 19 publications

(13 citation statements)

References 6 publications

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“…For instance, environments of tobacco smoke exposure are associated with increased smoking cues that may potentiate smoking behaviors among smokers (Field et al, 2007;McRobbie, Hajek, & Locker, 2008). Additionally, through the psychoactive effect of nicotine exposure from SHSe, novice smokers may be at increased susceptibility to initiate tobacco use (Anthonisen & Murray, 2005). Indeed, clinical studies have found that SHSe results in increased occupancy of nicotineacetylcholine receptors in the brains of adult smokers and nonsmokers, (Brody et al, 2011) suggesting increased neural vulnerability to nicotine exposure from SHS.…”

Section: Introductionmentioning

confidence: 99%

A systematic review of secondhand tobacco smoke exposure and smoking behaviors: Smoking status, susceptibility, initiation, dependence, and cessation

Okoli

Kodet

2015

Addictive Behaviors

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Section: Introductionmentioning

confidence: 99%

A systematic review of secondhand tobacco smoke exposure and smoking behaviors: Smoking status, susceptibility, initiation, dependence, and cessation

Okoli

Kodet

2015

Addictive Behaviors

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“…Third, cumulative SHSe may change physiology [15] to increase risk for smoking initiation. Fourth, individual differences in sensitivity to SHSe, whether due to genetics or experience, may contribute to the relationship between SHSe and smoking initiation [16]. This paper tests the latter mechanism in a sample of high-risk 8-13 year-old preteens who have never smoked and who were living with a smoker in the home.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity to Secondhand Smoke Exposure Predicts Smoking Susceptibility in 8–13-Year-Old Never Smokers

Lessov‐Schlaggar

Wahlgren

Liles

et al. 2011

Journal of Adolescent Health

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Purpose To investigate the sensitivity to secondhand smoke exposure (SHSe) in preteens age 8 to 13 who have never smoked, and to determine whether SHSe sensitivity predicts smoking susceptibility. Methods We assessed sensitivity to SHSe using reactions commonly used for assessment of sensitivity to the first smoked cigarette (e.g., feeling dizzy), and investigated the factor structure of these reactions for the purpose of data reduction. We examined the association of each reaction measure and summary score with demographic characteristics and with smoking susceptibility, using logistic regression and ordinal logistic regression. Results One factor was identified that captured physical/unpleasant reactions. Older preteens and preteens with more highly educated parents reported fewer reactions to SHSe. More African American preteens reported feeling relaxed or calm compared to all other racial/ethnic groups. Experiencing physical/unpleasant reactions to SHSe predicted lower risk for smoking susceptibility. Conclusions This was the first study to extend analytical methodology for sensitivity to active smoking to sensitivity to SHSe in youth who have never smoked. Results suggest a desensitization process with age and lower sensitivity to some reactions in preteens from more highly educated households. Preteens who have more aversive experience s with SHSe tend to be less susceptible to smoking than those who experience fewer aversive reactions. Assessment of sensitivity to SHSe is a novel approach to the study of cigarette use etiology and may contribute to better prediction of smoking initiation.

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“…One mechanism that could account for the relationship between SHSe and smoking behavior is genetics, because children who live with parents who smoke likely have an inherited predisposition to smoking. [18][19][20][21] A second mechanism is individual differences in sensitivity to SHSe, 22 which could be influenced by genetic predisposition to smoking, genetic predisposition in sensitivity to SHSe, 23,24 by cumulative SHSe, by existing medical conditions, or a combination of these and other factors. A third mechanism is access to cigarettes and the modeling of smoking behavior to which exposed children are subject.…”

mentioning

confidence: 99%

Sensitivity to Secondhand Smoke Exposure Predicts Future Smoking Susceptibility

Lessov‐Schlaggar

Wahlgren²,

Liles³

et al. 2011

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT:Passive exposure to cigarette smoke in children is toxic and associated with susceptibility to cigarette smoking. In turn, smoking susceptibility predicts smoking initiation. These relationships suggest that exposure to cigarette smoke in childhood contributes to risk for future cigarette smoking. WHAT THIS STUDY ADDS:Sensitivity to exposure to cigarette smoke may be a mechanism that helps explain the relationship between passive exposure and smoking susceptibility. Tobacconaive preteens who report cigarette smoke as "unpleasant or gross" have substantially reduced susceptibility to smoking. abstract OBJECTIVE: Susceptibility to cigarette smoking in tobacco-naive youth is a strong predictor of smoking initiation. Identifying mechanisms that contribute to smoking susceptibility provide information about early targets for smoking prevention. This study investigated whether sensitivity to secondhand smoke exposure (SHSe) contributes to smoking susceptibility. PARTICIPANTS AND METHODS:Subjects were high-risk, ethnically diverse 8-to 13-year-old subjects who never smoked and who lived with at least 1 smoker and who participated in a longitudinal SHSe reduction intervention trial. Reactions (eg, feeling dizzy) to SHSe were assessed at baseline, and smoking susceptibility was assessed at baseline and 3 follow-up measurements over 12 months. We examined the SHSe reaction factor structure, association with demographic characteristics, and prediction of longitudinal smoking susceptibility status. RESULTS:Factor analysis identified "physically unpleasant" and "pleasant" reaction factors. Reported SHSe reactions did not differ across gender or family smoking history. More black preteens reported feeling relaxed and calm, and fewer reported feeling a head rush or buzz compared with non-Hispanic white and Hispanic white counterparts. Longitudinally, 8.5% of subjects tracked along the trajectory for high (versus low) smoking susceptibility. Reporting SHSe as "unpleasant or gross" predicted a 78% reduction in the probability of being assigned to the high-smoking susceptibility trajectory (odds ratio: 0.22 [95% confidence interval: 0.05-0.95]), after covariate adjustment. CONCLUSIONS:Assessment of SHSe sensitivity is a novel approach to the study of cigarette initiation etiology and informs prevention interventions. Pediatrics 2011;128:254-262

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A new childhood pathway for transmission of an increased likelihood of smoking?

Cited by 19 publications

References 6 publications

A systematic review of secondhand tobacco smoke exposure and smoking behaviors: Smoking status, susceptibility, initiation, dependence, and cessation

A systematic review of secondhand tobacco smoke exposure and smoking behaviors: Smoking status, susceptibility, initiation, dependence, and cessation

Sensitivity to Secondhand Smoke Exposure Predicts Smoking Susceptibility in 8–13-Year-Old Never Smokers

Sensitivity to Secondhand Smoke Exposure Predicts Future Smoking Susceptibility

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