A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA‐
            <i>g</i>
            ‐OLA)s

Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI.

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“…Attaching the poly-HEMA to oligo- d -lactide to form a gel phase of the poly-HEMA without using lethal chemicals, have also been reported. [80] …”

Section: Injectable Hydrogelsmentioning

confidence: 99%

Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

et al. 2015

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“…[38][39][40][41][42][43] Hennink and co-workers reported stereocomplex hydrogels of PLLA-and PDLAgrafted dextrans. [39] Feijen and co-workers reported that PEG-PLA star diblock copolymers, PEG-(PDLA) 8 and PEG-(PDLA) 8 , form stereocomplex hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Temperature‐Induced Hydrogels Through Self‐Assembly of Cholesterol‐Substituted Star PEG‐b‐PLLA Copolymers: An Injectable Scaffold for Tissue Engineering

Nagahama

Ouchi

Ohya

2008

Adv Funct Materials

148

107

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Partially cholesterol‐substituted 8‐arm poly(ethylene glycol)‐block‐poly(L‐lactide) (8‐arm PEG‐b‐PLLA‐cholesterol) has been prepared as a novel star‐shaped, biodegradable copolymer derivative. The amphiphilic 8‐arm PEG‐b‐PLLA‐cholesterol aqueous solution (polymer concentration, above 3 wt%) exhibits instantaneous temperature‐induced gelation at 34 °C, but the virgin 8‐arm PEG‐b‐PLLA does not, irrespective of concentration. Moreover, an extracellular matrix (ECM)‐like micrometer‐scale network structure has been created with favorable porosity for three‐dimensional proliferation of cells inside the hydrogel. This network structure is mainly attributed to specific self‐assembly between cholesterol groups. The 10 and 20 wt% hydrogels are eroded gradually in phosphate buffered saline at 37 °C over the course of a month, and after that the gel becomes completely dissociated. Moreover, L929 cells encapsulated into the hydrogel are viable and proliferate three‐dimensionally inside the hydrogels. Thus, in‐vitro cell culture studies demonstrate that 8‐arm PEG‐b‐PLLA‐cholesterol is a promising candidate as a novel injectable cellular scaffold.

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“…[25,26] Blends of poly(LLA) and poly(DLA) form a stereo-complex with a melting point of approximately 230 8C. [27] Stereo-complex formation between poly(LLA) and poly(DLA) has been used to prepare physically cross-linked biodegradable hydrogels, [28][29][30] scaffolds for tissue engineering [31,32] and carriers for drug delivery. [33,34] In this paper we report on the preparation of physically cross-linked TMC-based TPEs.…”

Section: Introductionmentioning

confidence: 99%

Triblock Copolymers Based on 1,3‐Trimethylene Carbonate and Lactide as Biodegradable Thermoplastic Elastomers

Zhang

Grijpma

Feijén

2004

Macro Chemistry & Physics

143

137

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Summary: Biodegradable triblock copolymers based on 1,3‐trimethylene carbonate (TMC) and different lactides (i.e. D,L‐lactide(DLLA), L‐lactide (LLA), D‐lactide (DLA)) designated as poly(DLLA‐TMC‐DLLA), poly(LLA‐TMC‐LLA) and poly(DLA‐TMC‐DLA) were prepared and their mechanical and thermal properties were compared with those of high molecular weight poly(TMC) and poly(TMC‐co‐DLLA) statistical copolymers. Triblock copolymers containing crystallizable LLA or DLA segments perform as thermoplastic elastomers (TPEs) when the poly(lactide) blocks are long enough to crystallize. In blends of poly(LLA‐TMC‐LLA) and poly(DLA‐TMC‐DLA) triblock copolymers, stereo‐complex formation between the enantiomeric poly(lactide) segments occurs as demonstrated by differential scanning calorimetry and light microscopy. These blends have good tensile properties and excellent resistance to creep under static and dynamic loading conditions.Permanent deformation (after 2 h recovery) of compression‐molded poly(TMC) and solvent‐cast poly(LLA‐TMC‐LLA) and poly(ST‐TMC‐ST) films.imagePermanent deformation (after 2 h recovery) of compression‐molded poly(TMC) and solvent‐cast poly(LLA‐TMC‐LLA) and poly(ST‐TMC‐ST) films.

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A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA‐ g ‐OLA)s

Cited by 93 publications

References 18 publications

Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

Temperature‐Induced Hydrogels Through Self‐Assembly of Cholesterol‐Substituted Star PEG‐b‐PLLA Copolymers: An Injectable Scaffold for Tissue Engineering

Triblock Copolymers Based on 1,3‐Trimethylene Carbonate and Lactide as Biodegradable Thermoplastic Elastomers

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