A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging

Song, Xiaorong; Zhu, Wei; Xia, Ge; Li, Renfu; Li, Shihua; Chen, Xian; Song, Jibin; Xie, Jianping; Chen, Xueyuan; Yang, Huanghao

doi:10.1002/anie.202010870

Cited by 196 publications

(118 citation statements)

References 55 publications

Supporting

Mentioning

118

Contrasting

Order By: Relevance

“…Gold nanoclusters, with their superior biocompatibility, high stability, and rapid excretion, are good candidates for biomedical and bioimaging applications. [4,5] However, while bright near-infrared PL from ≈750-900 nm (the first near-infrared window, NIR-I) has been reported in several gold nanoclusters, [6][7][8][9][10][11][12] the reported NIR-II emissions from gold nanoclusters [13][14][15][16][17][18] still suffer from low QYs (<3%) and limited spectral range (peak wavelength less than ≈1100 nm). More importantly, the underlying electronic transitions, atomic-level structure-property relations, and the fundamental mechanisms for improvement of the performance of the NIR-II PL in gold nanoclusters still remain unexplored.…”

Section: Fluorophores With High Quantum Yields Extended Maximum Emismentioning

confidence: 99%

Bright NIR‐II Photoluminescence in Rod‐Shaped Icosahedral Gold Nanoclusters

Zeman

et al. 2021

Small

106

View full text Add to dashboard Cite

Fluorophores with high quantum yields, extended maximum emission wavelengths, and long photoluminescence (PL) lifetimes are still lacking for sensing and imaging applications in the second near‐infrared window (NIR‐II). In this work, a series of rod‐shaped icosahedral nanoclusters with bright NIR‐II PL, quantum yields up to ≈8%, and a peak emission wavelength of 1520 nm are reported. It is found that the bright NIR‐II emission arises from a previously ignored state with near‐zero oscillator strength in the ground‐state geometry and the central Au atom in the nanoclusters suppresses the non‐radiative transitions and enhances the overall PL efficiency. In addition, a framework is developed to analyze and relate the underlying transitions for the absorptions and the NIR‐II emissions in the Au nanoclusters based on the experimentally defined absorption coefficient. Overall, this work not only shows good performance of the rod‐shaped icosahedral series of Au nanoclusters as NIR‐II fluorophores, but also unravels the fundamental electronic transitions and atomic‐level structure‐property relations for the enhancement of the NIR‐II PL in gold nanoclusters. The framework developed here also provides a simple method to analyze the underlying electronic transitions in metal nanoclusters.

show abstract

Section: Fluorophores With High Quantum Yields Extended Maximum Emismentioning

confidence: 99%

Bright NIR‐II Photoluminescence in Rod‐Shaped Icosahedral Gold Nanoclusters

Zeman

et al. 2021

Small

106

View full text Add to dashboard Cite

show abstract

“…[23b,28] TheP Le xcitation spectrum for emission at % 1270 nm well matches with the absorption spectrum ( Figure S12), indicating the origin of the PL from the NCs.F urthermore,t he PL quantum yield (PLQY) of Ag 44 (EBT) 26 (TPP) 4 is found to be % 0.26 %, which is enhanced by > 25-and > 10-folds compared to the reported [Ag 44 (SR) 30 ] 4À ( % 0.01 %) [1b] and [Ag 44 (EBT) 30 ] 4À ( % 0.02 %), respectively.I mportantly,t he PLQY of Ag 44 -(EBT) 26 (TPP) 4 is > 5-folds higher compared to that of the standard dye IR26 (0.05 %) and also comparable to PLQY of cyclodextrin-protected gold NCs ( % 0.11 %). [29] Thei ncrease of PLQY of Ag 44 (EBT) 26 (TPP) 4 NCs is attributed to the Figure 4. Analysis of the computed optical spectrum of Ag 44 (EBT) 26 -(TPP) 4 .Panels (A, C, and E) show the transition contributionm aps (TCMs) for peaks at 775, 530 and 415 nm, respectively,and panels (B, D, and F) show the corresponding transition-induced hole-electron densities.…”

Section: Resultsmentioning

confidence: 96%

Ag₄₄(EBT)₂₆(TPP)₄ Nanoclusters With Tailored Molecular and Electronic Structure

et al. 2021

View full text Add to dashboard Cite

Although atomically precise metalloid nanoclusters (NCs) of identical sizew ith distinctly different molecular structures are highly desirable to understand the structural effects on the optical and photophysical properties,t heir synthesis remains highly challenging.H erein, we employed phosphine and thiol capping ligands featuring appropriate steric effects and synthesized acharge-neutral Ag NC with the formula Ag 44 (EBT) 26 (TPP) 4 (EBT:2-ethylbenzenethiolate; TPP:t riphenylphosphine). The single-crystal X-rays tructure reveals that this NC has ahollowmetal core of Ag 12 @Ag 20 and am etal-ligand shell of Ag 12 (EBT) 26 (TPP) 4 .T he presence of mixed ligands and long V-shaped metal-ligand motifs on this NC has resulted in an enhancement of the NIR-II photoluminescence quantum yield by > 25-fold compared to an allthiolate-stabilized anionic [Ag 44 (SR) 30 ] 4À NC (SR:t hiolate). Time-dependent density-functional calculations showt hat our Ag 44 NC is an 18-electron superatom with am odulated electronic structure as compared to the [Ag 44 (SR) 30 ] 4À anion, significantly influencing its optical properties.

show abstract

“…Recently, Yang et al. synthesized cyclodextrin‐protected NIR‐II AuNCs with superior biocompatibility [69] . The biological imaging of synthesized AuNCs can be achieved through somatic or protein labeling, which couldtrack the physiological behavior of proteins and used for tumor targeting visualization.…”

Section: Nir‐ii Materials (Fluorophores)mentioning

confidence: 99%

Activatable NIR‐II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives

et al. 2021

View full text Add to dashboard Cite

With the advantage of inherent responsiveness that can change the spectroscopic signals from “off” to “on” state in responding to targets (e. g. biological analytes/microenvironmental factors), activatable fluorescent probes have attracted extensive attention and made significant progress in the field of bioimaging and biosensing. Due to the high depth of tissue penetration, minimal tissue damage and negligible background signal at longer wavelengths, the development of second near‐infrared window (NIR‐II) fluorescent materials provides a new opportunity to develop activable fluorescent probes. Here, we summarized properties, advantages and disadvantages of mainly NIR‐II fluorophores (such as rare earth‐doped nanoparticles, quantum dots, single‐walled carbon nanotubes, small molecule dyes, conjugated polymers and gold nanoclusters), then overviewed current role and development of activatable NIR‐II fluorescent probes (AFPs) for biomedical applications including biosensing, bioimaging and therapeutic. The potential challenges and perspectives of AFPs in deep‐tissue imaging and clinical application are also discussed.

show abstract

A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging

Cited by 196 publications

References 55 publications

Bright NIR‐II Photoluminescence in Rod‐Shaped Icosahedral Gold Nanoclusters

Bright NIR‐II Photoluminescence in Rod‐Shaped Icosahedral Gold Nanoclusters

Ag₄₄(EBT)₂₆(TPP)₄ Nanoclusters With Tailored Molecular and Electronic Structure

Activatable NIR‐II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives

Contact Info

Product

Resources

About

A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging

Cited by 196 publications

References 55 publications

Bright NIR‐II Photoluminescence in Rod‐Shaped Icosahedral Gold Nanoclusters

Bright NIR‐II Photoluminescence in Rod‐Shaped Icosahedral Gold Nanoclusters

Ag44(EBT)26(TPP)4 Nanoclusters With Tailored Molecular and Electronic Structure

Activatable NIR‐II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives

Contact Info

Product

Resources

About

Ag₄₄(EBT)₂₆(TPP)₄ Nanoclusters With Tailored Molecular and Electronic Structure