A new class of protein mimics: preparation and electrophoretic properties of polycationic β-alanine-based dendrimers

Chow, Hak‐Fun; Mong, Tony K.-K.; Chan, Yat‐Sun; Chen, Cheng

doi:10.1016/s0040-4020(03)00431-9

Cited by 16 publications

(7 citation statements)

References 24 publications

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“…Our general interest in the properties of ferrocene (Fc)−peptide conjugates − led us to explore the generational effect in peptide dendrimers on the redox properties of a central Fc group. Although there are several examples of peptide-based dendrimers, − including l -glutamic acid-based dendrimers, − the synthesis of Fc-based peptide dendrimers has not been reported in the literature to date.…”

Section: Introductionmentioning

confidence: 99%

Glutamic Acid Dendrimers Attached to a Central Ferrocene Core: Synthesis and Properties

Appoh

Thomas²,

Kraatz

2005

Macromolecules

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The first synthesis of a series of glutamic acid based dendrimers having a central ferrocene core is described. The materials were fully characterized spectroscopically and display strong intramolecular H-bonding. This H-bonding can be disrupted with DMSO. The redox properties of the core are attenuated by the increase in the peptide dendritic sphere. But even at generation 6, there is communication between the exterior and the redox core.

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Section: Introductionmentioning

confidence: 99%

Glutamic Acid Dendrimers Attached to a Central Ferrocene Core: Synthesis and Properties

Appoh

Thomas²,

Kraatz

2005

Macromolecules

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“…The exquisite control of size, shape, and surface chemistry that is possible with dendrimers has already led to their use as replacements for proteins in a variety of applications. These uses include diagnostics, 8 gene delivery, 34 molecular weight calibrators, 23,35 presentation of antigens, 36 enzyme mimics, 37 site isolation, 24 globular protein mimics, 29,35 etc. 38 This letter reports a significant extension to this broad strategy and now involves self-assembly of DNA modified dendritic components.…”

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confidence: 99%

Designed Dendrimer Syntheses by Self-Assembly of Single-Site, ssDNA Functionalized Dendrons

2004

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Single site, functionalized, single stranded (ssDNA) dendri-poly(amidoamine) (PAMAM) di-dendrons have been synthesized by covalently conjugating complementary 32 base pair oligonucleotides to single-site, thiol functionalized dendri-PAMAM di-dendrons possessing neutral or anionic surface groups. Combining these complementary (ss-DNA) functionalized PAMAM di-dendrons at appropriate assembly temperatures produced Watson−Crick base paired (dsDNA) cores, surrounded by four PAMAM dendrons. These novel core−shell nanostructures represent a new class of precise monodisperse, linear-dendritic architectural copolymers. Using comparative gel electrophoresis, it was demonstrated that these self-assembled (di-dendron) dendrimers could be hemispherically differentiated as a function of surface chemistry as well as generational size. This new supramacromolecular approach offers a very facile and versatile strategy for the combinatorial design of size, shape, and surface substituents for both homogeneous and differentiated dendritic nanostructures.

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“…To date, a number of artificial peptide mimics have been reported. 60,110,111 For example, Huang et al 110 prepared a peptidomimetic, poly(amidoamine)-poly(benzyl L-glutamate) amphiphiles with adjustable sizes. These self-assembled aggregates were stable in aqueous solution for 64 days at room temperature and 16 days at 37 °C which showed potential applications as a drug/gene carrier.…”

Section: Bioinspired Artificial Proteins and Peptidesmentioning

confidence: 99%

“…These self-assembled aggregates were stable in aqueous solution for 64 days at room temperature and 16 days at 37 °C which showed potential applications as a drug/gene carrier. Chow et al 111 obtained peptidomimetics with similar size of native protein. This peptidomimetics exhibited the same electrophoretic mobilities and might be used as a size marker for protein analysis.…”

Section: Bioinspired Artificial Proteins and Peptidesmentioning

confidence: 99%

Recent developments and applications of bioinspired dendritic polymers

Shang

Ding

et al. 2015

Polym. Chem.

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Nowadays, the bioinspired strategy has become a prevalent guide for the design and fabrication of various novel materials. Due to their unique steric structures and rich peripheral functional groups, dendritic polymers can be designed for various bioinspired functions. This review begins with a brief introduction on the preparation of dendritic polymers, followed by the discussion of their physicochemical and biological properties. Then, a detailed review will focus on their bioinspired applications such as artificial proteins, virus, enzymes, cellular structures and light harvesting antenna, including our own studies. This review highlights the structure-function relationship of dendritic polymers to their bioinspired applications. Finally, an outlook will be proposed about the developing trends and challenges in this field.

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A new class of protein mimics: preparation and electrophoretic properties of polycationic β-alanine-based dendrimers

Cited by 16 publications

References 24 publications

Glutamic Acid Dendrimers Attached to a Central Ferrocene Core: Synthesis and Properties

Glutamic Acid Dendrimers Attached to a Central Ferrocene Core: Synthesis and Properties

Designed Dendrimer Syntheses by Self-Assembly of Single-Site, ssDNA Functionalized Dendrons

Recent developments and applications of bioinspired dendritic polymers

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