A new colorimetric fluorescent sensor for ratiometric detection of cyanide in solution, test strips, and in cells

Abstract

A new high selective and sensitive fluorescent sensor for the detection of cyanide was developed based on the nucleophilic attack of CN À with a color change from purple to colourless. The chemosensor was used for fabrication of test strips that can detect cyanide in aqueous samples. The living animal fluorescence experiment demonstrated the practical value of the sensor in tracing the CN À in biological systems.

A novel highly sensitive and selective fluorescent sensor for imaging mercury(ii) in living cells

“…10 To gain the insight into the observed uorescence quenching, we may consider that the specic binding between sensor 1 and Hg 2+ change the stereochemical structure of sensor 1, and then interrupted the p-conjugation and affected the intramolecular electron density distribution, resulting in the uorescence quenching to Hg 2+ in aqueous solution. 11 The observation was in good agreement with the afore-mentioned design concept.…”

“…Furthermore, the association constant of complex of sensor 1 with Hg 2+ was found to be 8.667 Â 10 6 mol À1 (R ¼ 0.99611) according to the linear Benesi-Hildebrand (Fig. 5) expression [10][11][12], which based on the relationship between absorbance [1/(A À A 0 )] and 1/[Hg 2+ ] at 368 nm in absorption spectrum. 10 To gain the insight into the observed uorescence quenching, we may consider that the specic binding between sensor 1 and Hg 2+ change the stereochemical structure of sensor 1, and then interrupted the p-conjugation and affected the intramolecular electron density distribution, resulting in the uorescence quenching to Hg 2+ in aqueous solution.…”

Organic chemodosimeter for cyanide: A nucleophilic approach

“…33). 55 The probe had a short responding time, low detection limit (6.67 × 10 -8 M). The probe showed nice visible color change from purple to colorless and green fluorescence upon addition of cyanide.…”

Stepwise Assembly of Turn‐on Fluorescence Sensors in Multicomponent Metal–Organic Frameworks for in Vitro Cyanide Detection

“…The fluorescence intensity was linearly related to the concentration of CN − within the range of 0 to 2.67 μ m (Figure e). The CN − detection limit was determined to be 0.05 μ m , which is much lower than the detection limit of traditional CN − molecular fluorescence sensors (approximately 0.2 μ m ) and the permissible level of CN − in drinking water according to the World Health Organization (WHO, 1.9 μ m ) . Moreover, PCN‐700‐L1‐L2Hcy‐75 % possessed high selectivity towards CN − over other competitive anions, including F − , Cl − , Br − , I − , CO 3 2− , HCO 3 − , SO 4 2− , HSO 4 − , NO 3 − , HCOO − , AcO − , and SCN − .…”