A new complex ceramic coating with carbon nanotubes, hydroxyapatite and TiO2 nanotubes on Ti surface for biomedical applications

Prodana, Mariana; Duta, Marius; Ioniță, Daniela; Bojin, Dionezie; Stan, Miruna Silvia; Dinischiotu, Anca; Demetrescu, Ioana

doi:10.1016/j.ceramint.2015.01.060

Cited by 71 publications

(32 citation statements)

References 29 publications

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“…It is well documented that preparation of porous TiO 2 film or TiO 2 nanotubes improves the cell viability due to the higher surface energy, a larger number of par ticle-binding sites, and the topology mechanism. 35,106 Cell attachment and proliferation are also improved. Furthermore, TiO 2 nanotube films can provide antimicrobial activity particularly under ultraviolet (UV) radiation and/or in the presence of silver ions ( Figure 2E and F).…”

Section: Surface Nanostructuringmentioning

confidence: 99%

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Nanomedicine applications in orthopedic medicine: state of the art

Mazaheri¹,

Eslahi²,

Ordikhani³

et al. 2015

IJN

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The technological and clinical need for orthopedic replacement materials has led to significant advances in the field of nanomedicine, which embraces the breadth of nanotechnology from pharmacological agents and surface modification through to regulation and toxicology. A variety of nanostructures with unique chemical, physical, and biological properties have been engineered to improve the functionality and reliability of implantable medical devices. However, mimicking living bone tissue is still a challenge. The scope of this review is to highlight the most recent accomplishments and trends in designing nanomaterials and their applications in orthopedics with an outline on future directions and challenges.

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Section: Surface Nanostructuringmentioning

confidence: 99%

“…Many studies have also focused on utilizing carbon nanostructures as orthopedic implants coatings. 50 Prodana et al 106 developed a complex ceramic coating on Ti plates with TiO 2 nanotubes, HA NPs, and functionalized MWCNTs. The complex coating showed a better biological adhesion and osteoblasts response.…”

Section: Nanostructured Coatingsmentioning

confidence: 99%

Nanomedicine applications in orthopedic medicine: state of the art

Mazaheri¹,

Eslahi²,

Ordikhani³

et al. 2015

IJN

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“…Accordingly, a considerable amount of effort has been directed at improving the biocompatibility of biomaterials in order to reduce such complications. Some examples of these attempts have included a layer by layer assembly, surface grafting and alterations in surface morphology . Ranella et al, utilized the microstructure of nanosilicon materials as an approach to impact cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

“…Some examples of these attempts have included a layer by layer assembly, surface grafting and alterations in surface morphology. [3][4][5][6][7][8][9] Ranella et al, 5 utilized the microstructure of nanosilicon materials as an approach to impact cell adhesion. With the use of a femtosecond laser, they produced silicon wafers with different surfaces that varied from smooth to very coarse.…”

Section: Introductionmentioning

confidence: 99%

PCL films of varying porosity influence ICAM‐1 expression of HUVECs

Shen

et al. 2016

J Biomedical Materials Res

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Here, we investigate the relationship between the expression of intercellular adhesion molecule-1 (ICAM-1) and the adhesion of human umbilical vein endothelial cells (HUVECs) on a poly-ε-caprolactone (PCL) film with micropores of different pore sizes. The results showed that surface hydrophilicity increased with larger pore sizes, while surfaces became less hydrophilic as the pore size decreased. The ability for adhesion and proliferation of HUVECs on surfaces with larger pore sizes was enhanced as compared with that of surfaces with smaller pore sizes or a flat film. Furthermore, levels of mICAM-1 were increased and sICAM-1 decreased as a function of increasing pore size. These findings demonstrate that film surfaces with larger pore sizes may promote cell adhesion and proliferation and lead to increases in expression of mICAM-1. Thus, we conclude that the pore size of the material's surface exerts a significant impact on the expression of adhesion molecules, the expression of which can represent an important new marker for investigating cell-surface adhesion and proliferation. Moreover, as elevated levels of sICAM-1 are associated with conditions such as inflammation, thrombosis, cerebral infarct and other diseases in vivo, it may serve as an early-warning risk marker when using medical biomaterials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2775-2784, 2016.

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“…Only a few studies on the use of HAp as a catalyst support to produce CNF/HAp composites using a mixture of methane and nitrogen have been reported for potential applications in the dental and medical fields [18][19][20]. CNF-containing HAp-based composites are candidates for use in implants due to their enhanced mechanical properties [21][22][23]. The chemical inertness of HAp is an important property for a material that will be used as a catalyst support.…”

Section: Introductionmentioning

confidence: 99%

Growth of carbon nanofibers from methane on a hydroxyapatite-supported nickel catalyst

et al. 2016

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Carbon nanofibers (CNFs) were grown using catalytic chemical vapor deposition (CCVD) with methane as the carbon source and a hydroxyapatite-supported nickel catalyst (Ni/HAp). The catalyst, which contained approximately 14 wt% Ni, was prepared using the incipient wetness method with an aqueous nickel nitrate solution. Temperature-programmed reduction and X-ray diffraction were used to characterize the active phase of Ni/HAp. Three variables were evaluated to optimize the CNF growth process, including the temperature and the time of catalyst reduction as well as the reaction time, at 650°C. Regardless of the applied CCVD process conditions, herringbone bamboo-like CNFs were grown during methane decomposition over Ni/HAp, which was confirmed using transmission electron microscopy. A high CNF yield of nearly 10 g CNF g cat -1was achieved at 650°C after a reaction time of 3 h when the catalyst was subjected to a reduction at the same temperature for 2 h under a hydrogen flow prior to synthesis. As the reduction temperature increased from 450 to 650°C, both the yield and diameters of the CNFs increased. The beneficial effects of including hydrogen in the reaction mixture on the catalytic performance of Ni/ HAp and the purity of the grown CNFs were demonstrated.

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A new complex ceramic coating with carbon nanotubes, hydroxyapatite and TiO2 nanotubes on Ti surface for biomedical applications

Cited by 71 publications

References 29 publications

Nanomedicine applications in orthopedic medicine: state of the art

Nanomedicine applications in orthopedic medicine: state of the art

PCL films of varying porosity influence ICAM‐1 expression of HUVECs

Growth of carbon nanofibers from methane on a hydroxyapatite-supported nickel catalyst

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