A New Comprehensive Study on Aging the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)

Shimokata, Hiroshi; Ando, Fujiko; Niino, Naoakira

doi:10.2188/jea.10.1sup_1

Cited by 201 publications

(136 citation statements)

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“…The NILS-LSA was based on data obtained from interviews and laboratory examinations of medical, nutritional, psychological, and physical fitness variables. The details of the study can be found elsewhere 10) . The initial survey of the NILS-LSA involved 2,267 men and women aged 40-79 years, including almost 300 men and 300 women for each decade (40s, 50s, 60s and 70s).…”

Section: Study Populationmentioning

confidence: 99%

Regular exercise history as a predictor of exercise in community-dwelling older Japanese people

Kozakai

Ando

Kim

et al. 2012

JPFSM

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A physically active lifestyle is important across the entire life span. However, little is known about life-long participation in regular exercise among older people. The purpose of the present study was to describe regular exercise throughout a person's lifetime and evaluate the impact of exercise earlier in life on participation in exercise at age 60 and over. The participants were 984 community-dwelling older people aged 60 to 86 years. Each participant's life was divided into five age categories: 12-19, 20-29, 30-39, 40-59, and 60 years and over. The association between exercise at an earlier age and that at 60 years and over was assessed using logistic regression analysis adjusted for potential confounders. Men had exercised throughout their lives more than women. Among women, participation in exercise during their 20s and 30s showed a sharp decline. The preference for exercise differed according to age and gender. Among men, the most common patterns of exercise throughout life were exercise during all the age categories, and starting exercise at age 60 and over; whereas in women the most common pattern was no exercise at all. The adjusted odds ratio of exercise at 40-59 years for exercise at age 60 and over was 5.85 (95% confidence interval: 3.82-8.96) among men and 6.89 (4.23-11.23) among women. Regular exercise in the younger age categories affected exercise at age 60 and over among men, but not among women. Regular exercise at 40-59 years was a strong predictor of exercise at 60 years and over in both men and women.

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Section: Study Populationmentioning

confidence: 99%

Regular exercise history as a predictor of exercise in community-dwelling older Japanese people

Kozakai

Ando

Kim

et al. 2012

JPFSM

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“…Details of the NILS-LSA study are reported elsewhere. 14 Subjects in this study included 1189 men and 1194 women aged 40-86 years who participated in the fourth wave of the NILS-LSA from June 2004 to July 2006. Subjects under non-pharmacological and/or pharmacological treatment for hypertension, hypertriglyceridemia or diabetes were excluded, as were subjects who indicated that they were aware of having these disorders but were not undergoing treatment.…”

Section: Study Subjectsmentioning

confidence: 99%

Relationship between number of metabolic syndrome components and dietary factors in middle-aged and elderly Japanese subjects

et al. 2010

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Metabolic syndrome (MetS) represents a cluster of risk factors for atherosclerosis and is considered a risk factor for cardiovascular disease. The role of diet in the etiology of MetS is poorly understood, especially among Asian subjects. This cross-sectional study assessed the relationship between diet and the number of MetS components among Japanese men (n¼609) and women (n¼631). Mean (s.d.) age and body mass index were 57.1 (12.1) years and 22.8 (2.8) kg m À2 for men and 55.5 (12.0) years and 22.0 (3.0) kg m À2 for women, respectively. Diet was assessed by a 3-day dietary record that included photographs: 16 nutrients, 11 food groups, and energy % of protein and dietary fat were selected as a dietary index. The definition of MetS was based on modified National Cholesterol Education Program, Adult Treatment Panel III criteria, and the number of clustering MetS components was calculated by adding the presence of each five MetS components. A total of 61 men (10.0%) and 46 women (7.3%) were determined to have MetS. After adjusting for age, energy intake, alcohol intake, smoking status and physical activity, a lower intake of vitamin B6 and dietary fiber in men, and lower intake of calcium, milk and dairy products and higher intake of cereal in women were related to the number of MetS components. These results suggest that some dietary factors were related to the number of MetS components among community-dwelling Japanese men and women. Keywords: cross-sectional study; dietary record; Japanese; metabolic syndrome INTRODUCTION Metabolic syndrome (MetS) represents a cluster of risk factors for atherosclerosis, including visceral obesity, hypertension, dyslipidemia and hyperglycemia; MetS is considered a risk factor for cardiovascular disease. 1 The National Nutrition Survey in Japan, a population-based study among 40-to 74-year-olds, revealed that 24% of men and 12% of women were strongly suspected of having MetS, and 27% of men and 8% of women were suspected of having MetS. 2 MetS has become a major public health challenge in Japan. 3 The pathophysiology of MetS appears to be largely attributable to insulin resistance with an excessive flux of fatty acids, 1 although this disorder presumably exists as a function of a complex interaction between environmental factors, including diet or physical activity and genetic factors. 4,5 Although dietary aspects have been linked to individual features of MetS, 6-8 the role of diet in the etiology of this syndrome is poorly understood. Asians have different lifestyle and genetic factors compared with Caucasians, 9,10 but only a few epidemiologic studies examining diet and MetS among Asians have been conducted. [11][12][13] The aim of this study was to examine the relations between diet and

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“…The details of the NILS-LSA have been described elsewhere. 11 Randomly selected men and women were invited by mail to attend an explanatory meeting. At that meeting, the procedures for each examination and the follow-up schedule were fully explained.…”

Section: Subjectsmentioning

confidence: 99%

Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort

Kuzuya

Ando²,

Iguchi

et al. 2006

Int J Obes

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Objective: To investigate whether Leu72Met polymorphism of the preproghrelin gene is associated with overweight/obesity in middle-aged and older Japanese. Design: Cross-sectional analysis. Subjects: A total of 2238 community-dwelling middle-aged and older Japanese people (age: 40-79 years) who participated in the first wave of examinations in the National Institute for Longevity Sciences -Longitudinal Study of Aging from April 1998 to March 2000. Measurements: The Leu72Met polymorphism of prepoghrelin gene, anthropometric variables including body weight, body mass index (BMI), waist circumference, waist-to-hip ratio and whole-fat mass and biochemical variables including serum lipid levels, fasting plasma glucose, insulin and homeostasis model assessment for insulin resistance. Results: The frequencies of the Leu72Leu, Leu72Met and Met72Met alleles were 63.4, 32.7 and 4.0%, respectively. No differences in the genotype distributions of the Leu72Met polymorphism were found between genders or age groups, and no significant associations were observed between polymorphism and anthropometric variables in women and older men. However, middle-aged men who were 72Met allele carriers showed a higher body weight change from body weight at 18 years of age, as well as a higher waist circumference and a tendency to a higher waist-hip-ratio than noncarriers. Although there were no significant differences in the genotype distribution according to BMI in women and older men, a significantly higher frequency of the 72Met allele was found in the higher BMI group (BMIX25 kg/m 2 ) of middle-aged men than in the normalweight group. No significant associations were observed between polymorphism and serum lipid, glucose or insulin levels. Conclusions: These results suggest that the 72Met allele of the preproghrelin gene is a contributing factor for midlife weight change in men.

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A New Comprehensive Study on Aging the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)

Cited by 201 publications

References 0 publications

Regular exercise history as a predictor of exercise in community-dwelling older Japanese people

Regular exercise history as a predictor of exercise in community-dwelling older Japanese people

Relationship between number of metabolic syndrome components and dietary factors in middle-aged and elderly Japanese subjects

Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort

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