We study constant and variable fluid properties together to investigate their effect on MHD Powell–Eyring nanofluid flow with thermal radiation and heat generation over a variable thickness sheet. The similarity variables assist in having ordinary differential equations acquired from partial differential equations (PDEs). A novel numerical procedure, the simplified finite difference method (SFDM), is developed to calculate the physical solution. The SFDM described here is simple, efficient, and accurate. To highlight its accuracy, results of the SFDM are compared with the literature. The results obtained from the SFDM are compared with the published results from the literature. This gives a good agreed solution with each other. The velocity, temperature, and concentration distributions, when drawn at the same time for constant and variable physical features, are observed to be affected against incremental values of the flow variables. Furthermore, the impact of contributing flow variables on the skin friction coefficient (drag on the wall) and local Nusselt (heat transfer rate on the wall) and Sherwood numbers (mass transfer on the wall) is illustrated by data distributed in tables. The nondimensional skin friction coefficient experiences higher values for constant flow regimes especially in comparison with changing flow features.