We develop a novel approach to the dark matter halos in the context of 4 dimensional Einstein-scalar-Gauss-Bonnet gravity. This approach gives a possible interpretation of the problem of the galaxy rotation curves. Moreover, the Gauss-Bonnet coupling describes the interior structure of the galaxies, while there is a presence of a scalar field φ in the galaxy edges. This can provide an interesting interpretation for the functional coupling f (φ). We discuss how this comparison can naturally drive the observed percentages of matter and dark matter in the Universe. The effective mass range in our model is 10 −2 kg − 10 3 kg, which is in good agreement with the constraints on primordial black holes.