A new contrast agent for radiological and dissection studies of the arterial network of anatomic specimens

Bulla, Antonio; Casoli, C.; Farace, Francesco; Mazzarello, Vittorio; Luca, Laura De; Rubino, Corrado; Montella, Andrea

doi:10.1007/s00276-013-1143-z

Cited by 11 publications

(18 citation statements)

References 11 publications

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“…Even though barium sulfate was already used to visualize arterial microvascular structures, no accounts of contrast agent use intended for the detection of lymphatic vessels on micro CT could be found; these results are encouraging for further in‐depth characterization of lymphatic vessels. Should it prove possible to retrogradely fill lymphatic vessels up to a diameter smaller than 0.3 mm (detection range of regular CT scanner with barium sulfate contrast (Bulla et al )), using barium sulfate as contrast agent for micro CT could theoretically show lymphatic vessels up to 0.07 mm in diameter (Kingston et al ) if they can be filled in the same way as the arterial microvascular structures visualized in the previous studies.…”

Section: Introductionmentioning

confidence: 99%

Call for a Multidisciplinary Effort to Map the Lymphatic System with Advanced Medical Imaging Techniques: A Review of the Literature and Suggestions for Future Anatomical Research

Stouthandel

Veldeman

Hoof

2019

The Anatomical Record

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This review intends to rekindle efforts to map the lymphatic system by using a more modern approach, based on medical imaging. The structure, function, and pathologies associated with the lymphatic system are first discussed to highlight the need for more accurately mapping the lymphatic system. Next, the need for an interdisciplinary approach, with a central role for the anatomist, to come up with better maps of the lymphatic system is emphasized. The current approaches on lymphatic system research involving medical imaging will be discussed and suggestions will be made for an all‐encompassing effort to thoroughly map the entire lymphatic system. A first‐hand account of our integration as anatomists in the radiotherapy department is given as an example of interdisciplinary collaboration. From this account, it will become clear that the interdisciplinary collaboration of anatomists in the clinical disciplines involved in lymphatic system research/treatment still holds great promise in terms of improving clinical regimens that are currently being employed. As such, we hope that our fellow anatomists will join us in an interdisciplinary effort to map the lymphatic system, because this could, in a relatively short timeframe, provide improved treatment options for patients with cancer or lymphatic pathologies all over the world. Anat Rec, 302:1681–1695, 2019. © 2019 American Association for Anatomy

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Section: Introductionmentioning

confidence: 99%

Call for a Multidisciplinary Effort to Map the Lymphatic System with Advanced Medical Imaging Techniques: A Review of the Literature and Suggestions for Future Anatomical Research

Stouthandel

Veldeman

Hoof

2019

The Anatomical Record

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“…No previous studies have compared contrast preparations for use in micro-CT angiography. In fresh human cadavers injected and scanned with conventional CT scanners (3,4), the smallest vessel measured was 0.4 mm (lead oxide gelatin), and 0.3 mm (barium sulfate resin) (3,4). In this study the smallest vessel diameter measured was 0.07 mm for both barium sulfate resin and lead oxide milk powder preparations.…”

Section: Discussionmentioning

confidence: 48%

“…Fifty grams of barium sulfate (E‐Z‐HD™, E‐Z‐EM, Westbury, NY, USA) was thoroughly combined with 80 ml of compound A (Kinetix® R118 Infusion Resin, ATL Composites, Molendinar, Australia) and 20 mL of compound B (Kinetix® H120 Infusion Hardener, ATL Composites, Molendinar, Australia) in a fumehood. The solution was then degassed in the fumehood prior to injection .…”

Section: Methodsmentioning

confidence: 99%

“…Barium sulfate, in contrast, is non-toxic. Typically mixed with gelatin or latex to achieve a thin consistency for optimal dispersal into the fine vessels, a new technique mixing barium sulfate with epoxy resin has recently been reported for CT angiography (4,9). There was agreement, to the smallest detectable arteries (0.1 mm diameter), between the CT angiographic images and corresponding dissection studies (4).…”

Section: Introductionmentioning

confidence: 94%

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Contrast agent comparison for three‐dimensional micro‐CT angiography: A cadaveric study

Kingston

Perriman

Neeman

et al. 2016

Contrast Media & Molecular

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Barium sulfate and lead oxide contrast media are frequently used for cadaver-based angiography studies. These contrast media have not previously been compared to determine which is optimal for the visualisation and measurement of blood vessels. In this study, the lower limb vessels of 16 embalmed Wistar rats, and four sets of cannulae of known diameter, were injected with one of three different contrast agents (barium sulfate and resin, barium sulfate and gelatin, and lead oxide combined with milk powder). All were then scanned using micro-computed tomography (CT) angiography and 3-D reconstructions generated. The number of branching generations of the rat lower limb vessels were counted and compared between the contrast agents using ANOVA. The diameter of the contrast-filled cannulae, were measured and used to calculate the accuracy of the measurements by comparing the bias and variance of the estimates. Intra- and inter-observer reliability were calculated using intra-class correlation coefficients. There was no significant difference (mean difference [MD] 0.05; MD 95% confidence interval [CI] -0.83 to 0.93) between the number of branching generations for barium sulfate-resin and lead oxide-milk powder. Barium sulfate-resin demonstrated less bias and less variance of the estimates (MD 0.03; standard deviation [SD] 1.96 mm) compared to lead oxide-milk powder (MD 0.11; SD 1.96 mm) for measurements of contrast-filled cannulae scanned at high resolution. Barium sulfate-resin proved to be more accurate than lead oxide-milk powder for high resolution micro-CT scans and is preferred due to its non-toxicity. This technique could be applied to any embalmed specimen model. Copyright © 2016 John Wiley & Sons, Ltd.

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“…1,2 In cadaveric dissections, the intra-arterial injection of different fluid materials allows for better visualization of the vasculature during dissection, improving the understanding of the vascular anatomy. 3 Silicone, gelatin-lead oxide, and latex have all been described. 4 Gelatin-lead oxide is superior in marking small vessels, but not as easily accessible as silicone or latex.…”

mentioning

confidence: 99%

Vascular Coloration for Anatomical Study of the Pelvis and Hip: Implications in Hip Preservation Surgery

Chahla

Sánchez

Moatshe

et al. 2017

Arthroscopy Techniques

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Hip preservation surgical techniques have steadily increased in the recent past. Therefore, precise knowledge of the vascular system of the hip and pelvis is critical for avoidance of possibly devastating complications during surgery. A colored latex injection in the common iliac artery of cadavers allows for a complete staining of the hip and pelvis vascular system. This technique creates more resilient vessels, whereas coloration with dye causes the vessels to be highly visible in comparison with the surrounding tissue. The proposed colored latex-dye solution injection allows for complete identification of the circulatory system of the lower extremity with specific focus on the hip and pelvis. This technique is simple, reproducible, and easily usable by orthopaedic surgeons in the laboratory to better understand the vascularization of the lower limb. The purpose of this technical note is to describe our technique for the injection of latex-dye solution in the common iliac artery, followed by dissection to key vascular structures of the hip and pelvis.

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A new contrast agent for radiological and dissection studies of the arterial network of anatomic specimens

Cited by 11 publications

References 11 publications

Call for a Multidisciplinary Effort to Map the Lymphatic System with Advanced Medical Imaging Techniques: A Review of the Literature and Suggestions for Future Anatomical Research

Call for a Multidisciplinary Effort to Map the Lymphatic System with Advanced Medical Imaging Techniques: A Review of the Literature and Suggestions for Future Anatomical Research

Contrast agent comparison for three‐dimensional micro‐CT angiography: A cadaveric study

Vascular Coloration for Anatomical Study of the Pelvis and Hip: Implications in Hip Preservation Surgery

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