A new coumarin from <i>Perezia hebeclada</i>

Hernández-Carlos, Beatríz; Burgueño‐Tapia, Eleuterio; Joseph‐Nathan, Pedro

doi:10.1002/mrc.1284

Cited by 5 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5). The structures were elucidated using one-and two-dimensional NMR spectroscopic techniques and by comparison of their spectroscopic and spectrometric data (see Supporting Information) with those previously described in the literature [23][24][25]. This is the first report on the presence of compound 4 in this species.…”

Section: Resultsmentioning

confidence: 92%

Antidiabetic and Antihyperalgesic Effects of a Decoction and Compounds from Acourtia thurberi

et al. 2016

View full text Add to dashboard Cite

The purpose of this research was to examine the preclinical efficacy of a decoction from the roots of as a hypoglycemic, antihyperglycemic, and antihyperalgesic agent using well-known experimental models in mice. Acute oral administration of decoction did not produce toxic effects in mice, according to the Lorke procedure. decoction (31.6-316.2 mg/kg, p. o.) decreased blood glucose levels during acute hypoglycemic and the oral glucose tolerance and oral sucrose tolerance tests, both in normoglycemic and hyperglycemic animals. Phytochemical analysis of roots led to the isolation of perezone (), a mixture of -pipitzol () and -pipitzol (), and 8--D-glucopyranosyloxy-4-methoxy-5-methyl-coumarin (). A pharmacological evaluation of compounds - (3.2-31.6 mg/kg) using the same assays revealed their hypoglycemic and antihyperglycemic actions. Finally, local administration of decoction (31.6-316.2 µg/paw) and compounds- (3.2-31.6 µg/paw) produced significant inhibition on the licking time during the formalin test in healthy and hyperglycemic mice, demonstrating their antinociceptive and antihyperalgesic potential, respectively. Altogether, these results could be related to the use of for treating diabetes and painful complaints in contemporary Mexican folk medicine. A suitable UPLC-ESI/MS method was developed and successfully applied to quantify simultaneously compounds and in decoction.

show abstract

Section: Resultsmentioning

confidence: 92%